Control of batch crystallizers for the production of pharmaceuticals and fine chemicals

VDI Berichte

Volumn , Issue 1901 II, 2005, Pages 1039-1044

  Rohani, S ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICALS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG PRODUCTS; FEEDBACK CONTROL; MATHEMATICAL MODELS; MIXING; MORPHOLOGY; OPTIMAL CONTROL SYSTEMS; STEARIC ACID; SUPERSATURATION;

BATCH CRYSTALLIZERS; CRYSTAL SIZE DISTRIBUTION (CSD); OPERATING TEMPERATURE; TAUTOMERIC POLYMORPHISM;

CRYSTALLIZERS;

EID: 27344445462     PISSN: 00835560     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (11)

1. Fevotte, G. New perspectives for the on-line monitoring of pharmaceutical crystallization processes usingan in-situ infrared spectroscopy. Int. J. Pharmaceut., 241, 263-278 (2000).
2. Fujiwara, M., P. S. Chow, D. L. Ma and R. D. Braatz. Paracetamolcrystallization using laser backscattering and ATR FTIR spectroscopy: Metastability, agglomeration and control. Crystal Growth Des. 2, 363-370 (2000).
3. Hojjati, H. and S. Rohani. Cooling and seeding effect on supersaturation and final crystal size distribution (CSD) of ammonium sulphate in a batch crystallizer. Chem. Eng. & Processing, in print (2004).
4. Hu, Q., S. Rohani, D.X. Wang and A. Jutan. Nonlinear Kinetic Parameter Estimation for Batch Cooling Seeded Crsytallization, AIChE J., 50(8), 1786-1794 (2004).
5. Hundal, H. S., S. Rohani, H. C. Wood and M. N. Pons. Particle Shape Characterization Using Image Analysis and Neural Networks", Powder Technol., 91, 217-227 (1997).
6. Mirmehrabi, M., S. Rohani and L. Perry. Thermodynamic Modeling and Prediction of Drug Solubility in Solvents: Part 2. The MRP, the UNIQUAC and the NRTL Models, Pharmaceutical Res., submitted (2004a).
7. Mirmehrabi, M. and S. Rohani. An Approach to Solvent Screening for Crystallization of Polymorphic Pharmaceuticals and Fine Chemicals, J. Pharmaceutical Sci., accepted (2004b).
8. Mirmehrabi, M., S. Rohani, K. S. K. Murthy and B. K. Radatus. Optimization of Operating Conditions for Improving the Physical Properties of Form 1 Ranitidine Hydrochloride, J. Pharmaceutical Sci., 93(7) 1692-1700 (2004c).
9. Prausnitz, J. M., R. N. Lichtenthaler and E. G. Azevedo. Molecular thermodynamics of fluid-phase equilibria. Prentice-Hall, Upper Saddle River, New Jersey, pp. 59-77 (1999).
10. Togkalidou, T., H.-H. Tung, Y. Sun, A. Andrews and R. D. Braatz. Solution concentration prediction for pharmaceutical crystallization processes using robust chemometrics and ATR FTIR spectroscopy. Org. Proc. Res. Dev. 6, 317-322 (2002).
11. Wang, F., J. A. Wachter, F. J. Antosz and K. A. Berglund. An investigation of solvent-mediated polymorphic transformation of progesterone using in-situ Raman spectroscopy, Org. Proc. Res. Dev. 4, 391-395 (2000).