Metaplastic sarcomatoid carcinoma of the breast with absent or minimal overt invasive carcinomatous component: A misnomer

American Journal of Surgical Pathology

Volumn 29, Issue 11, 2005, Pages 1456-1463

  Davis, William G ^a   Hennessy, Bryan ^a   Babiera, Gildy ^a   Hunt, Kelly ^a   Valero, Vicente ^a   Buchholz, Thomas A ^a   Sneige, Nour ^a   Gilcrease, Michael Z ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Metaplastic carcinoma; Sarcomatoid carcinoma; Spindle cell carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CARCINOMA; BREAST SURGERY; CANCER CLASSIFICATION; CANCER RADIOTHERAPY; CANCER SIZE; CLINICAL ARTICLE; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; METAPLASTIC CARCINOMA; POSTOPERATIVE CARE; SARCOMATOID CARCINOMA; SPINDLE CELL CARCINOMA; TREATMENT OUTCOME;

BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; FEMALE; HUMANS; MASTECTOMY; NEOPLASM INVASIVENESS;

EID: 27244459936     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000176431.96326.49     Document Type: Article

References (46)

1. Adem C, Reynolds C, Adlakha H, et al. Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patients. Histopathology. 2002;40:556-562
2. Azzopardi JG. Problems in breast pathology, in Bennington JL: Major problems in pathology, Vol. 11. Philadelphia, PA, Saunders, 1979.
3. Barrow BJ, Janjan NA, Gutman H, et al. Role of radiotherapy in sarcoma of the breast: a retrospective review of the M.D. Anderson experience. Radiother Oncol. 1999;52:173-178.
4. Blanchard DK, Reynolds CA, Grant CS, et al. Primary nonphylloides breast sarcomas. Am J Surg. 2003;186:359-361.
5. Collini P, Sampietro G, Bertulli R, et al. Cytokeratin immunoreactivity in 41 cases of ES/PNET confirmed by molecular diagnostic studies. Am J Surg Pathol 2001;25:273-274.
6. Corson JM, Weiss LM, Banks-Schlegel SP, et al. Keratin proteins in synovial sarcoma. Am J Surg Pathol 1983;7:107-109.
7. Dunne B, Lee AH, Finder SE, et al. An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast. Hum Pathol. 2003;34:1009-1015.
8. Eusebi V, Lamovec J, Cattani MG, et al. Acantholytic variant of squamous-cell carcinoma of the breast. Am J Surg Pathol. 1986;10:855-861.
9. Fanburg-Smith JC, Hengge M, Hengge UR, et al. Extrarenal rhabdoid tumors of soft tissue: a clinicopathologic and immunohistochemical study of 18 cases. Ann Diagn Pathol. 1998;2:351-362.
10. Fitzgibbons PL, Page DL, Weaver D, et al. Prognostic factors in breast cancer: College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000;124:966-978.
11. Foschini MP, Eusebi V. Carcinomas of the breast showing myoepithelial cell differentiation: a review of the literature. Virchows Arch. 1998;432: 303-310.
12. Franke WW, Schmid E, Freudenstein C, et al. Intermediate-sized filaments of the prekeratin type in myoepithelial cells. J Cell Biol. 1980; 84:633-654.
13. Gobbi H, Simpson JF, Borowsky A, et al. Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer. 1999;85:2170-2182.
14. Gutman H, Pollock RE, Janjan NA, et al. Biologic distinctions and therapeutic implications of sarcomatoid metaplasia of epithelial carcinoma of the breast. J Am Coll Surg. 1995;180:193-199.
15. Holden J, Churg A. Immunohistochemical staining for keratin and carcinoembryonic antigen in the diagnosis of malignant mesothelioma. Am J Surg Pathol. 1984;8:277-279.
16. Homick JL, Bosenberg MW, Mentzel T, et al. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol. 2004;28:1257-1267.
17. Huvos AG, Lucas JC Jr, Foote FW Jr. Metaplastic breast carcinoma: rare form of mammary cancer. N Y State J Med. 1973;73:1078-1082.
18. Iwata J, Fletcher CD. Immunohistochemical detection of cytokeratin and epithelial membrane antigen in leiomyosarcoma: a systematic study of 100 cases. Pathol Int. 2000;50:7-14.
19. Kaufman MW, Marti JR, Gallager HS, et al. Carcinoma of the breast with pseudosarcomatous metaplasia. Cancer. 1984;53:1908-1917.
20. Koker MM, Kleer CG. p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma. Am J Surg Pathol. 2004; 28:1506-1512.
21. Lakhani SR, O'Hare MJ, Monaghan P, et al. Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study. J Clin Pathol 1995;48:164-167.
22. Laskin WB, Miettinen M. Epithelioid sarcoma: new insights based on an extended immunohistochemical analysis. Arch Pathol Lab Med. 2003; 127:1161-1168.
23. Leibl S, Gogg-Kammerer M, Sommersacher A, et al. Metaplastic breast carcinomas: are they of myoepithelial differentiation? Immunohistochemical profile of the sarcomatoid subtype using novel myoepithelial markers. Am J Surg Pathol. 2005;29:347-353.
24. Meis-Kindblom JM, Kindblom LG. Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol. 1998;22:683-697.
25. Miettinen M, Fetsch JF. Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol. 2000;31:1062-1067.
26. Miettinen M, Rapola J. Immunohistochemical spectrum of rhabdomyosarcoma and rhabdomyosarcoma-like tumors: expression of cytokeratin and the 68-kD neurofilament protein. Am J Surg Pathol. 1989;13: 120-132.
27. Oberman HA. Metaplastic carcinoma of the breast: a clinicopathologic study of 29 patients. Am J Surg Pathol. 1987;11:918-929.
28. Pitts WC, Rojas VA, Gaffey MJ, et al. Carcinomas with metaplasia and sarcomas of the breast. Am J Clin Pathol. 1991;95:623-632.
29. 27a. Perry A, Scheithauer BW, Nascimento AG. The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. Am J Surg Pathol. 1997;21:1354-1360.
30. Pollard SG, Marks PV, Temple LN, et al. Breast sarcoma: a clinicopathologic review of 25 cases. Cancer. 1990;66:941-944.
31. Rayson D, Adjei AA, Suman VJ, et al. Metaplastic breast cancer: prognosis and response to systemic therapy. Ann Oncol. 1999;10:413-419.
32. Reis-Filho JS, Milanezi F, Paredes J, et al. Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of the breast. Appl Immunohistochem Mol Morphol. 2003;11:1-8.
33. Rosenberg AE, O'Connell JX, Dickersin GR, et al. Expression of epithelial markers in malignant fibrous histiocytoma of the musculoskeletal system: an immunohistochemical and electron microscopic study. Hum Pathol. 1993;24:284-293.
34. Schurch W, Potvin C, Seemayer TA. Malignant myoepithelioma (myoepithelial carcinoma) of the breast: an ultrastructural and immunocytochemical study. Ultrastruct Pathol. 1985;8:1-11.
35. Smalley M, Ashworth A. Stem cells and breast cancer: a field in transit. Nat Rev Cancer. 2003;3:832-844.
36. Smith TA, Machen SK, Fisher C, et al. Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. Am J Clin Pathol. 1999;112:641-648.
37. Sneige N, Yaziji H, Mandavilli SR, et al. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol. 2001;25: 1009-1016.
38. Stephens FO. Induction chemotherapy: to downgrade aggressive cancers to improve curability by surgery and/or radiotherapy. Eur J Surg Oncol. 2001;27:672-688.
39. Thorner PS, Kahn HJ, Baumal R, et al. Malignant myoepithelioma of the breast: an immunohistochemical study by light and electron microscopy. Cancer. 1986;57:745-750.
40. Trent IJ 2nd, Benjamin RS, Valero V. Primary soft tissue sarcoma of the breast. Curr Treat Options Oncol. 2001;2:169-176.
41. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast: I. Matrix-producing carcinoma. Hum Pathol. 1989;20:628-635.
42. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast: III. Carcinosarcoma. Cancer. 1989;64:1490-1499.
43. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast: IV. Squamous cell carcinoma of ductal origin. Cancer. 1990;65: 272-276.
44. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast: V. Metaplastic carcinoma with osteoclastic giant cells. Hum Pathol. 1990; 21:1142-1150.
45. Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinomas of the breast: II. Spindle cell carcinoma. Hum Pathol. 1989;20:732-740.
46. Zelek L, Llombart-Cussac A, Terrier P, et al. Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 2003;21:2583-2588.