The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans

Molecules and Cells

Volumn 19, Issue 3, 2005, Pages 452-457

  Shim, Jaegal ^a,c   Lee, Junho ^a,b  

^a Yonsei University   (South Korea)

^b Seoul National University   (South Korea)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

AP 3; C. elegans; Clathrin; Lethality; RNAi

Indexed keywords

2 AMINO 3 PHOSPHONOPROPIONIC ACID; CLATHRIN; RNA; ADAPTOR PROTEIN; BETA ADAPTIN; DELTA ADAPTIN; MU ADAPTIN; SIGMA ADAPTIN;

ARTICLE; CAENORHABDITIS ELEGANS; EMBRYO DEVELOPMENT; GENE SEQUENCE; LARVAL DEVELOPMENT; MAMMALIAN GENETICS; NONHUMAN; PHENOTYPE; PROTEIN QUATERNARY STRUCTURE; VULVA; ANIMAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; PHYSIOLOGY; PRENATAL DEVELOPMENT; RNA INTERFERENCE;

CAENORHABDITIS ELEGANS; MAMMALIA;

ADAPTOR PROTEIN COMPLEX 3; ADAPTOR PROTEIN COMPLEX BETA SUBUNITS; ADAPTOR PROTEIN COMPLEX DELTA SUBUNITS; ADAPTOR PROTEIN COMPLEX MU SUBUNITS; ADAPTOR PROTEIN COMPLEX SIGMA SUBUNITS; ANIMALS; CAENORHABDITIS ELEGANS; LARVA; RNA INTERFERENCE;

EID: 27244457650     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Brenner, S. (1974) The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
2. Dell'Angelica, E. C., Shotelersuk, V., Aguilar, R. C., Gahl, W. A., and Bonifacino, J. S. (1999) Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3 A subunit of the AP-3 adaptor. Mol. Cell 3, 11-21.
3. Dell'Angelica, E. C., Mullins, C., Caplan, S., and Bonifacino, J. S. (2000) Lysosome-related organelles. FASEB J. 14, 1265-1278.
4. Feng, L., Seymour, A. B., Jiang, S., To, A., Peden, A. A., et al. (1999) The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness. Hum. Mol. Genet. 8, 323-330.
5. Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., et al. (2000) Functional genomic analysis of C. elegans chromosome 1 by systematic RNA interference. Nature 408, 325-330.
6. Kantheti, P., Qiao, X., Diaz, M. E., Peden, A. A., Meyer, G. E., et al. (1998) Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles. Neuron 21, 111-122.
7. Koushika, S. P. and Nonet, M. L. (2000) Sorting and transport in C. elegans: a model system with a sequenced genome. Curr. Opin. Cell Biol. 12, 517-523.
8. Kretzschmar, D., Poeck, B., Roth, H., Ernst, R., Keller, A., et al. (2000) Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3beta adaptin gene ruby. Genetics 155, 213-223.
9. Le Borgne, R., Alconada, A., Bauer, U., and Hoflack, B. (1998) The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins. J. Biol. Chem. 273, 29451-29461.
10. Lee, J., Jongeward, G. D., and Sternberg, P. W. (1994) unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein. Genes Dev. 8, 60-73.
11. Lloyd, V., Sinclair, D. A., Wennberg, R., Warner, T. S., Honda, B. M., et al. (1999) A genetic and molecular characterization of the garnet gene of Drosophila melanogaster. Genome 42, 1183-1193.
12. Lloyd, V., Ramaswami, M., and Kramer, H. (1998) Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery. Trends Cell Biol. 8, 257-259.
13. Maniatis, T., Fritsch, E. F., and Sambrook, J. (1989) Molecular Cloning, Cold Spring Harber Laboratory Press, Cold Spring Harber, NY.
14. Meyer, C., Zizioli, D., Lausmann, S., Eskelinen, E. L., Hamann, J., et al. (2000) mulA-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors. EMBO J. 19, 2193-2203.
15. Mullins, C., Hartnell, L. M., and Bonifacino, J. S. (2000) Distinct requirements for the AP-3 adaptor complex in pigment granule and synaptic vesicle biogenesis in Drosophila melanogaster. Mol. Gen. Genet. 263, 1003-1014.
16. Newman, L. S., McKeever, M. O., Okano, H. J., and Darnell, R. B. (1995) Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell 82, 773-783.
17. Odorizzi, G., Cowles, C. R., and Emr, S. D. (1998) The AP-3 complex: a coat of many colours. Trends Cell Biol. 8, 282-288.
18. Ooi, C. E., Moreira, J. E., Dell'Angelica, E. C., Poy, G., Wassarman, D. A., et al. (1997) Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet. EMBO J. 16, 4508-4518.
19. Pevsner, J., Volknandt, W., Wong, B. R., and Scheller, R. H. (1994) Two rat homologs of clathrin-associated adaptor proteins. Gene 146, 279-283.
20. Robinson, M. S. and Bonifacino, J. S. (2001) Adaptor-related proteins. Curr. Opin. Cell Biol. 13, 444-453.
21. Shim, J. and Lee, J. (2000) Molecular genetic analysis of apm-2 and aps-2, genes encoding the medium and small chains of the AP-2 clathrin-associated protein complex in the nematode Caenorhabditis elegans. Mol. Cells 10, 309-316.
22. Shim, J., Sternberg, P. W., and Lee, J. (2000) Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. Mol. Biol. Cell. 11, 2743-2756.
23. Simpson, F., Bright, N. A., West, M. A., Newman, L. S., Darnell, R. B., et al. (1996) A novel adaptor-related protein complex. J. Cell Biol. 133, 749-760.
24. Simpson, F., Peden, A. A., Christopoulou, L., and Robinson, M. S. (1997) Characterization of the adaptor-related protein complex, AP-3. J. Cell Biol. 137, 835-845.
25. Stepp, J. D., Huang, K., and Lemmon, S. K. (1997) The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. J. Cell Biol. 139, 1761-1774.
26. Zizioli, D., Meyer, C., Guhde, G., Saftig, P., von Figura, K., et al. (1999) Early embryonic death of mice deficient in gamma-adaptin. J. Biol. Chem. 274, 5385-5390.