Superior mobilisation of haematopoietic progenitor cells with glycosylated G-CSF in male but not female unrelated stem cell donors

British Journal of Haematology

Volumn 130, Issue 5, 2005, Pages 740-746

  Fischer, Johannes C ^a   Frick, Markus ^a   Wassmuth, Ralf ^a   Platz, Alexander ^a   Punzel, Michael ^a   Wernet, Peter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Gender difference; Glycosylated; Granulocyte colony stimulating factor; Mobilisation; Peripheral blood progenitor cell

Indexed keywords

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; CD34 ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN;

ADULT; ARTICLE; BODY WEIGHT; CELL COUNT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENDER; GLYCOSYLATION; HEMATOPOIETIC STEM CELL; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UNIVARIATE ANALYSIS; APHERESIS; COMPARATIVE STUDY; DONOR; EPIDEMIOLOGY; IMMUNOLOGY; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROSPECTIVE STUDY; QUALITY CONTROL; SEX RATIO; STATISTICAL MODEL; STEM CELL; STEM CELL MOBILIZATION;

ADULT; ANTIGENS, CD34; BLOOD COMPONENT REMOVAL; BODY WEIGHT; CELL COUNT; CONFOUNDING FACTORS (EPIDEMIOLOGY); FEMALE; FILGRASTIM; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROSPECTIVE STUDIES; QUALITY CONTROL; RECOMBINANT PROTEINS; SEX DISTRIBUTION; STEM CELLS; TISSUE DONORS;

EID: 27244453576     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05678.x     Document Type: Article

References (21)

1. Bäk W.B. ( 1997) Richtlinien zur Transplantation peripherer Blutstammzellen. Erarbeitet vom Wissenschaftlichen Beirat der Bundesärztekammer unter Mitwirkung des Paul-Ehrlich- Institutes. Deutsches Ärzteblatt, 94, A1584 A1592.
2. Basara N. Schmetzer B. Blau I.W. Bischoff M. Gunzelmann S. Kirsten D. Fauser A.A. ( 2000) Lenograstim-mobilized peripheral blood progenitor cells in volunteer donors: an open label randomized split dose escalating study. Bone Marrow Transplantation, 25, 371 376.
3. Carter C.R. Whitmore K.M. Thorpe R. ( 2004) The significance of carbohydrates on G-CSF: differential sensitivity of G-CSFs to human neutrophil elastase degradation. Journal of Leukocyte Biology, 75, 515 522.
4. El Ouriaghli F. Fujiwara H. Melenhorst J.J. Sconocchia G. Hensel N. Barrett A.J. ( 2003) Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis. Blood, 101, 1752 1758.
5. Fischer J.C. Kiesel U. Herda A. Wernet P. ( 2001) Factors influencing yield of G-CSF mobilized PBPC from unrelated donors: Interim results from an ongoing phase III study. Blood, 98 ( Suppl. 1 729 ( abstract).
6. Gratwohl A. Passweg J. Baldomero H. Horisberger B. Urbano-Ispizua A. ( 2002) Economics, health care systems and utilization of haematopoietic stem cell transplants in Europe. British Journal of Haematology, 117, 451 468.
7. Hayashi N. Kinoshita H. Yukawa E. Higuchi S. ( 1999) Pharmacokinetic and pharmacodynamic analysis of subcutaneous recombinant human granulocyte colony stimulating factor (lenograstim) administration. Journal of Clinical Pharmacology, 39, 583 592.
8. Hoglund M. Smedmyr B. Bengtsson M. Totterman T.H. Cour-Chabernaud V. Yver A. Simonsson B. ( 1997) Mobilization of CD34+ cells by glycosylated and nonglycosylated G-CSF in healthy volunteers - a comparative study. European Journal of Haematology, 59, 177 183.
9. Keeney M. Chin-Yee I. Weir K. Popma J. Nayar R. Sutherland D.R. ( 1998) Single platform flow cytometric absolute CD34+ cell counts based on the ISHAGE guidelines. International Society of Hematotherapy and Graft Engineering. Cytometry, 34, 61 70.
10. Kubota N. Orita T. Hattori K. Oh-eda M. Ochi N. Yamazaki T. ( 1990) Structural characterization of natural and recombinant human granulocyte colony-stimulating factors. Journal of Biochemistry, 107, 486 492.
11. Kuwabara T. Kato Y. Kobayashi S. Suzuki H. Sugiyama Y. ( 1994) Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): species differences among rats, monkeys and humans. Journal of Pharmacology and Experimental therapeutics, 271, 1535 1543.
12. Kuwabara T. Kobayashi S. Sugiyama Y. ( 1996) Pharmacokinetics and pharmacodynamics of a recombinant human granulocyte colony-stimulating factor. Drug Metabolism Reviews, 28, 625 658.
13. de La Rubia J. Diaz M.A. Verdeguer A. Pascual M.J. Arbona C. Arrieta R. Brunet S. Bargay J. Martinez C. Espigado I. Serrano D. Alegre A. de Arriba F. de La Serna J. Zamora C. Benlloch L. Sanz M.A. ( 2001) Donor age-related differences in PBPC mobilization with rHuG-CSF. Transfusion, 41, 201 205.
14. Nadler S.B. Hdalgo J.U. Bloch T. ( 1962) Prediction of blood volume in normal human adults. Surgery, 51, 224 232.
15. Souza L.M. Boone T.C. Gabrilove J. Lai P.H. Zsebo K.M. Murdock D.C. Chazin V.R. Bruszewski J. Lu H. Chen K.K. Barendt J. Platzer E. Moore M.A.S. Mertelsmann R. Welte K. ( 1986) Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science, 232, 61 65.
16. Stroncek D. Anderlini P. ( 2001) Mobilized PBPC concentrates: a maturing blood component. Transfusion, 41, 168 171.
17. Sutherland D.R. Anderson L. Keeney M. Nayar R. Chin-Yee I. ( 1996) The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering. Journal of Hematotherapy, 5, 213 226.
18. Tanaka H. Kaneko T. ( 1991) Sex differences in the pharmacokinetics of recombinant human granulocyte colony-stimulating factor in the rat. Drug Metabolism and Disposition, 19, 1034 1039.
19. Toth B. Schwacha M.G. Kuebler J.F. Bland K.I. Wang P. Chaudrya I.H. ( 2003) Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock. International Journal of Molecular Medicine, 11, 357 364.
20. Watts M.J. Addison I. Long S.G. Hartley S. Warrington S. Boyce M. Linch D.C. ( 1997) Crossover study of the haematological effects and pharmacokinetics of glycosylated and non-glycosylated G-CSF in healthy volunteers. British Journal of Haematology, 98, 474 479.
21. Whitehead J. Stratton I. ( 1983) Group sequential clinical trials with triangular continuation regions. Biometrics, 39, 227 236.