Arnold Heller and the lymph pump

Acta Physiologica Scandinavica

Volumn 185, Issue 3, 2005, Pages 171-180

  Aukland, K ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b Section of Physiology   (Norway)

Author keywords

Active propulsion; Biography; History; Lymph; Lymphatics

Indexed keywords

HUMAN; INTERSTITIAL FLUID; LANGUAGE; LYMPH FLOW; LYMPH VESSEL; MOLECULAR MECHANICS; MUSCLE FORCE; NONHUMAN; OBSERVATION; PERFUSION; PERILYMPH FISTULA; PRESSURE; PRIORITY JOURNAL; PUBLICATION; PULSATILE FLOW; PUMP; REVIEW; TECHNIQUE; VASOCONSTRICTION;

ANIMALS; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HUMANS; LYMPHATIC SYSTEM; PHYSIOLOGY; PULSATILE FLOW;

EID: 27244450154     PISSN: 00016772     EISSN: 1365201X     Source Type: Journal    
DOI: 10.1111/j.1365-201X.2005.01470.x     Document Type: Review

References (87)

1. Aarli, V. & Aukland, K. 1991. Oedema-preventing mechanisms in a low-compliant tissue: studies on the rat tail. Acta Physiol Scand 141, 489-495.
2. Aas, M., Skretting, A., Engeset, A., Westgaard, R. & Nicolaysen, G. 1985. Lymphatic drainage from subcutaneous tissue in the foot and leg in the sitting human. Acta Physiol Scand 125, 505-511.
3. Adair, T.H. & Guyton, A.C. 1983. Modification of lymph by lymph nodes. II. Effect of increased lymph node venous blood pressure. Am J Physiol 245 (Heart Circ Physiol 18), H616-H622.
4. Adair, T.H. & Guyton, A.C. 1985. Lymph formation and its modification in the lymphatic system. In: M.G. Johnston (ed.) Experimental Biology of the Lymphatic Circulation, pp. 13-44. Elsevier Science Publishers, Amsterdam.
5. Allen, J. M., McHale, N.G. & Rooney, B.M. 1983. Effect of norepinephrine on contractility of isolated mesenteric lymphatics. Am J Physiol 244 (Heart Circ Physiol 13), H479-H486.
6. Aukland, K. & Nicolaysen, G. 1981. Interstitial fluid volume: local regulatory mechanisms. Physiol Rev 61, 556-643.
7. Aukland, K. & Reed, R.K. 1993. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 73, 1-78.
8. Baez, S. 1960. Flow properties of lymph - a microcirculatory study. In: A.E. Copley & G. Stainsby (ed.) Flow Properties of Blood and other Biological Systems, pp. 398-411. Pergamon Press, New York.
9. Benoit, J.N. 1991. Relationships between lymphatic pump flow and total lymph flow in the small intestine. Am J Physiol 261, H1970-H1978.
10. Benoit, J.N., Zawieja, D.C., Goodman, A.H. & Granger, H.J. 1989. Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress. Am J Physiol 257, H2059-H2069.
11. Boardman, K.C. & Swartz, M.A. 2003. Interstitial flow as a guide for lymphangiogenesis. Circ Res 92, 801-808.
12. Borodin, Y.I. & Tomchik, G.V. 1965. Functional relationships between blood vessels and sinuses of the lymph nodes under normal conditions and in experimental disturbances of the blood and lymph circulation. Bull Exp Biol 60, 1142-1144.
13. Bridenbaugh, E.A., Gashev, A.A & Zawieja, D.C. 2003. Lymphatic muscle: A review of contractile function. Lymphatic Res Biol 1, 147-158.
14. Carrier, E. B. 1926. Observation of living cells in the bat's wing. In: J. Linhard (ed.) Physiological Papers Dedicated to Professor August Krogh, pp. 1-9. Levin & Munksgaard Publishers, Copenhagen.
15. Cope, O. & Litwin, S.B. 1962. Contribution of the lymphatic system to the replenishment of the plasma volume following a hemorrhage. Ann Surg 156, 655-667.
16. Drake, R.E., Dhother, S., Oppenlander, V.M & Gabel, J.C. 1996. Lymphatic pump function curves in awake sheep. Am J Physiol 270, R486-R488.
17. Drinker, C.K. & Field, M.E. 1933. Lymphatics, Lymph and Tissue Fluid, pp. 254. The William and Wilkins Company, Baltimore.
18. Drinker, C.K. & Yoffey, J.M. 1941. Lymphatics, Lymph, and Lymphoid Tissue, pp. 66-68. Harvard University Press, Cambridge, MA.
19. Edwards, J.M., Gough, M.H., Kinmonth, J.B. & Pierce, J.W. 1965. Spontaneous contractility of the human thoracic duct. J Physiol 177, 41-42.
20. Engeset, A., Olszewski, W., Jseger, P.M., Sokolowski, J. & Theodorsen, L. 1977. Twenty-four hour variation in flow and composition of leg lymph in normal men. Acta Physiol Scand 99, 140-148.
21. Florey, H. 1927a. Observations on the contractility of lacteals. Part I. J Physiol 62, 267-272.
22. Florey, H. 1927b. Observations on the contractility of lacteals. Part II. J Physiol 63, 1-18.
23. Gashev, A.A. 2002. Physiological aspects of lymphatic contractile functions. Current perspectives. Ann NY Acad Sci 979, 178-187.
24. Gashev, A.A., Davis, M.J. & Zawieja, D.C. 2002. Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct. J Physiol 540, 1023-1037.
25. Gashev, A.A. & Zawieja, D.C. 2001. Physiology of human lymphatic contractility: a historical perspective. Lymphology 34, 124-134.
26. Gaskell, W.H. 1896. Ueber die Wand der Lymphcapillaren. Physiologischen Anst Leipzig 11, 143-146.
27. Gulliver, G. 1846. The Works of William Hewson, F.R.S, pp. 360. The Sydenham Society, London.
28. Hall, J.G., Morris, B. & Woolley, M.G. 1965. Intrinsic rhythmic propulsion of lymph in the unanestethized sheep. J Physiol 180, 336-349.
29. Hanley, C.A., Elias, R.M. & Johnston, M.G. 1992. Is endothelium necessary for transmural pressure-induced contractions of bovine truncal lymphatics? Microvasc Res 43, 134-146.
30. Hargens, A.R. & Zweifach, B.W. 1977. Contractile stimuli in collecting lymph vessels. Am J Physiol 233, H57-H65.
31. Hayashi, A., Johnston, M.G., Nelson, W., Hamilton, S. & McHale, N.G. 1987. Increased intrinsic pumping of intestinal lymphatics following hemorrhage in anesthetized sheep. Circulation Res 60, 265-272.
32. Heller, A. 1869. Über selbständige rhytmische Contractionen der Lymphgefässe bei Säugetieren. Zentralbl fd med Wissensch 35, 545-548.
33. Heller, A. 1872. Üeber die Blutgefässe des Dünndarmes. Verhandl. d. K. Sachs. Gesellsch der Wissenshaften Mathematphysische Cl 24, 165-171.
34. Heller, A. 1911. Über die Fortbewegung der Lymphe in den Lymphgefässen. Centralbl für Physiol 25, 375-376.
35. Hogan, R.D. & Unthank, J.L. 1986. The initial lymphatics as sensors of interstitial fluid volume. Mircrovasc Res 31, 317-324.
36. Hong, Y.K., Shin, J.W. & Detmar, M. 2004. Development of the lymphatic vascular system: a mystery unravels. Dev Dyn 231, 462-473.
37. Horstmann, E. 1952. Über die functionelle Structur der mesenterialen Lymphgefässe. Gegenbaurs morphologisches Jahrbuch 91, 483-510.
38. Inagaki, M., Onizuka, M, Ishikawa, S., Yamamoto, T & Mitsui, T. 2000. Thoracic duct lymph flow and its driving pressure in anesthetized sheep. Lymphology 33, 4-11.
39. Johnston, M.G. 1985. Involvement of lymphatic collecting ducts in the physiology and pathophysiology of lymph flow. In: M.G. Johnston (ed.) Experimental Biology of the Lymphatic Circulation, Chapter 4, pp. 81-120. Elsevier Science Publishers, Amsterdam.
40. Kinmonth, J.B. & K.W. Taylor 1956. Spontaneous rhythmic contractility in human lymphatics. J Physiol (Lond) 133, 3P.
41. Koller, A., Mizuno, R & Kaley, G 1999. Flow reduces the amplitude and increases the frequency of lymphatic vasomotion: role of endothelial prostanoids. Am J Physiol 277, R1683-R1689.
42. Lieben, S. 1910. Über die Fortbewegung der Lymphe in den Lymphgefässen. Zbl Physiologie 24, 1164-1167.
43. Lubarsch, O. 1914. Arnold Heller. Proc German Soc Pathol 17, 585-587.
44. Lundgren, O. 1967. Blood flow distribution and counter current exchange in the small intestine. Acta Physiol Scand Suppl 303, 1-42.
45. Mayerson, H.S. 1963. The physiological importance of lymph. In: W.F. Hamilton & P. Dow (eds) Handbook of Physiology, section 2. Circulation, volume II. pp. 1035-1073. American Physiological Society, Washington, DC.
46. McGeown, J.G., McHale, N.G. & Thornbury, K.D. 1987a. The role of external compression and movement in lymph propulsion in the sheep hind limb. J Physiol 387, 83-93.
47. McGeown, J.G., McHale, N.G. & Thornbury, K.D. 1987b. The effect of electrical stimulation of the sympathetic chain on peripheral lymph flow in anaestetized sheep. J Physiol 393, 123-133.
48. McGeown, J.G., McHale, N.G., Roddie, I.C. & Thornbury, K. 1987c. Peripheral lymphatic responses to outflow pressure in anaestetized sheep. J Physiol 383, 527-536.
49. McHale, N.G. & Meharg, M.K. 1992. Co-ordination of pumping in isolated bovine lymphatic vessels. J Physiol 450, 503-512.
50. McHale, N.G. & Roddie, I.C. 1976. The effect of transmural pressure on pumping activity in isolated bovine lymphatic vessels. J Physiol 261, 255-269.
51. McHale, N.G. & Roddie, I.C. 1983. The effect of intravenous adrenaline and noradrenaline infusion on peripheral lymph flow in the sheep. J Physiol 341, 517-526.
52. McHale, N.G. & Thornbury, K.D. 1986. A method for studying lymphatic pumping activity in conscious and anaesthetized sheep. J Physiol 378, 109-118.
53. McHale, N.G. & Thornbury, K.D. 1989. The effect of anesthetics on lymphatic contractility. Microvasc Res 37, 70-76.
54. Mellander, S. 1978. On the control of capillary fluid transfer by precapillary and postcapillary vascular adjustments. Microvasc Res 15, 319-330.
55. Mislin, H. 1961a. Zur Funktionsanalyse der Lymphgefässmotorik. Rev Suisse Zool 68, 228-238.
56. Mislin, H. 1961b. Experimenteller Nachweis der autochtonen Automatic der Lymphgefässe. Experientia 17, 29-30.
57. Mislin, H. & Schipp, R. (1968) Structural and functional relations of the mesenteric lymph vessels. In: A. Rüttimann (ed.) Progress in Lymphology. International Symposium on Lymphology, pp. 360-365. Zürich 1966. Hafner, Stuttgart.
58. Mizuno, R., Koller, A. & Kaley, G. 1998. Regulation of the vasomotor activity of lymph microvessels by nitric oxide and prostaglandins. Am J Physiol 274, R790-R796.
59. Muthuchamy, M., Gashev, A., Boswell, N., Dawson, N. & Zawieja, D. 2003. Molecular and functional analyses of the contractile apparatus in lymphatic muscle. FASEB J. Express Article 10.1096/fj.02-0626fje. Published online, 28 March 2003.
60. Ng, C.P., Helm, C.-L.E. & Schwartz, M.A. 2004. Interstitial flow differentially stimulates blood and lymphatic endothelial cell morphogenesis in vitro. Microvasc Res 68, 258-264.
61. Ohhashi, T., Azuma, T. & Sakaguchi, M. 1980. Active and passive mechanical characteristics of bovine mesenteric lymphatics. Am J Physiol 239, H88-H95.
62. Oliver, G. 2004. Lymphatic vasculature development. Nat Rev Immunol 4, 35-45.
63. Olszewski, W.L. & Engeset, A. 1980. Intrinsic contractility of prenodal lymph vessels and lymph flow in human leg. Am J Physiol 239, H775-H783.
64. Olszewski, W., Engeset, A., Jæger, P.M., Sokolowski, J. & Theodorsen, L. 1977. Flow and composition of leg lymph in normal men during venous stasis, muscular activity and local hyperthermia. Acta Physiol Scand 99, 149-155.
65. Onizuka, M., Flatebø, T. & Nicolaysen, G. 1997. Lymph flow pattern in the intact thoracic duct in sheep. J Physiol 503, 223-234.
66. Pullinger, B.D. & Florey, H.W. 1935. Some observations on the structure and functions of lymphatics: their behaviour in local oedema. Br J Exp Pathol 16, 49-69.
67. Reddy, N.P. & Staub, N.C. 1981. Intrinsic propulsive activity of thoracic duct perfused in anesthetized dogs. Microvasc Res 21, 183-192.
68. Rusznyak, I., Földi, M. & Szabo, G. 1967. Lymphatics and Lymph Circulation, 2nd English edn, pp. 935. Pergamon, London.
69. Smith, R.O. 1949. Lymphatic contractility. A possible intrinsic mechanism of lymphatic vessels for the transport of lymph. J Exp Med 90, 497-509.
70. Stacker, S.A., Achen, M.G., Jussila, L, Baldwin, M.E. & Alitalo, K. 2002. Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2, 573-583.
71. Stanton, A.W.B., Levick, J.R. & Mortimer, P.S 1997. Chronic arm edema following breast cancer treatment. Kidney Int. 51 (Suppl. 59), S76-S81.
72. Szegvári, M., Lakos, A., Szontágh, F. & Földi, M. 1964. The active function of the subcutaneous lymphatic vessels of the human lower extremity. Acta Med Acad Sci Hung 20, 209-213.
73. Tigerstedt, R. 1911. Die Gewebsflüssigkeit und ihre Bewegung. Lehrbuch der Physiologie des Menschen. Erster Band, Sechste Auflage, pp. 457-462. Verlag von Hirzel, Leipzig.
74. Tsunemoto, H., Ikomi, F. & Ohhashi, T. 2003. Flow-mediated release of nitric oxide from lymphatic endothelial cells of pressurized canine thoracic duct. Jpn J Physiol 53, 157-163.
75. Unthank, J.L. & Hogan, R.D. 1988. Modulation of the spontaneous contractions of the initial lymphatics of the bat's wing by arterial and venous occlusion. Blood Vessels 25, 115-121.
76. VanHelden, D.F. 1993. Pacemaker potentials in lymphatic smooth muscle of the guinea-pig mesentery. J Physiol 471, 465-479.
77. Waldeck, F. 1965a. Zur Motorik der Lymphgefässe bei der Ratte. I. Mitteilung. Die Bedeutung aktiver Kontraktionen der Lymphgefässe für den Lymphtransport. Pflügers Arch 283, 285-293.
78. Waldeck, F. 1965b. Zur Motorik der Lymphgefässe bei der Ratte. II. Mitteilung. Die contractilen Eigenschaften der Muskulatur der Leberlymphgefässe. Pflügers Arch 283, 294-300.
79. Webb, R.L. 1933. Observations on the propulsion of lymph through the mesenteric lymphatic vessels of the living rat. Anat Res 57, 345-350.
80. Webb, R.L. & Nicoll, P.A. 1944. Behavior of lymphatic vessels in the living *rat. Anat Rec 88, 351-367 (*Misspelling for bat in cited reference heading).
81. Wen, S., Dörffler-Melly, J., Herrig, I., Schiesser, M., Franzek, U.K. & Bollinger, A. 1994. Fluctuation of skin lymphatic capillary pressure in controls and in patients with primary lymphedema. Int J Microcir 14, 139-143.
82. White, J.C., Field, M.E. & Drinker, C.K. 1933. On the protein content and normal flow of lymph from the foot of the dog. Am J Physiol 103, 34-44.
83. Wiederhielm, C.A. & Weston, B.V. 1973. Microvascular, lymphatic, and tissue pressures in the unanesthetized mammal. Am J Physiol 225, 992-996.
84. Yoffey, J.M. & Courtice, F.C. 1956. Lymphatics, Lymph and Lymphoid Tissue, pp. 19-22 and 220-221. Harvard University Press, Cambridge, MA.
85. Yoffey, J.M. & Courtice, F.C. 1970. Lymphatics, Lymph and the Lymphomyeloid Complex, Chapter 3, pp. 160-205. Academic Press, London-New York.
86. Zawieja, D.C., Davis, K.L., Schuster, R., Hinds, W.M. & Granger, H.J. 1993. Distribution, propagation, and coordination of contractile activity in lymphatics. Am J Physiol 264, H1283-H1291.
87. Zweifach, B.W. & Prather, J.W. 1975. Micromanipulation of pressure in terminal lymphatics in the mesentery. Am J Physiol 228, 1326-1335.