Synthesis and cytotoxic activity of silacycloalkyl-substituted heterocyclic aldehydes and their thiosemicarbazones

Applied Organometallic Chemistry

Volumn 19, Issue 10, 2005, Pages 1109-1113

  Lukevics, Edmunds ^a   Ignatovich, Luba ^a   Sleiksha, Ilze ^a   Shestakova, Irina ^a   Domrachova, Ilona ^a   Popelis, Jury ^a  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

1,1 bis(5 formyl 2 furyl) 1 silacyclo pentane hexane; 5 1 methylsilacyclo pentyl hexyl 2 furfural; 5 1 methylsilacyclo pentyl hexyl 2 thiophene carbaldehyde; Cytotoxicity; Thiosemicarbazones; Toxicity

Indexed keywords

BIOASSAY; CELL CULTURE; SYNTHESIS (CHEMICAL); TOXICITY;

1,1-BIS(5-FORMYL-2-FURYL)SILACYCLO-PENTANE/-HEXANE; 5-[1-METHYLSILACYCLO-PENTYL/-HEXYL]-2-FURFURAL; 5-[1-METHYLSILACYCLO-PENTYL/-HEXYL]-2-THIOPHENE CARBALDEHYDE; CYTOTOXICITY; THIOSEMICARBAZONES;

ALDEHYDES;

EID: 27144557220     PISSN: 02682605     EISSN: None     Source Type: Journal    
DOI: 10.1002/aoc.961     Document Type: Article

References (10)

1. Lukevics E, Ignatovich L. Biological activity of organosilicon compounds. In Metallotherapeutic Drugs & Metal-based Diagnostic Agents. The Use of Metals in Medicine, Gielen M, Tiekink RT (eds). Wiley: 2005; 83-107.
2. Lukevics E, Abele E, Arsenyan P, Abele R, Rubina K, Shestakova I, Domracheva I, Vologdina V. Metal-Based Drugs 2002; 9: 45.
3. Abele E, Abele R, Arsenyan P, Shestakova I, Kanepel, Antonenko I, Popelis J, Lukevics E. Bioinorg. Chem. Appl. 2003; 1: 299.
4. Easmon J, Purstringer G, Heinisch G, Roth T, Fiebig HH, Holzer W, Jager W, Jenney M, Hofmann J. J. Med. Chem. 2001; 44: 2164.
5. Hall IH, Wong OT, Chapman JM. Anticancer Drugs 1995; 6: 147.
6. West R. J. Am. Chem. Soc. 1954; 76: 6012.
7. Fast DJ, Lynch RC, Leu RW. J. Leucocyt. Biol. 1992; 52: 255.
8. Freshney PJ. Culture of Animal Cells (A Manual of Basic Technique). Wiley-Liss: New York, 1994; 29.
9. Denat F, Gaspard-Iloughmane H, Dubac J. Synthesis 1992; 10: 954.
10. Thames SF, Odom HC. J. Heterocycl. Chem. 1966; 3: 490.