Effects of desipramine and escitalopram on postprandial symptoms induced by the nutrient drink test in healthy volunteers: A randomized, double-blind, placebo-controlled study

Digestion

Volumn 72, Issue 2-3, 2005, Pages 97-103

  Talley, Nicholas J ^a,d   Camilleri, Michael ^a   Chitkara, Denesh K ^a   Bouras, Ernest ^b   Locke III, G Richard ^a   Burton, Duane ^a   Rucker, Mary Jo ^a   Thapa, Prabin ^c   Zinsmeister, Alan R ^c  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

^c Mayo Clinic   (United States)

^d Clinical Enteric Neuroscience Translational and Epidemiological Research Mayo Clinic   (United States)

Author keywords

Antidepressants; Desipramide; Escitalopram; Nutrient drink test; Postprandial symptoms

Indexed keywords

DESIPRAMINE; ENSURE; ESCITALOPRAM;

ADULT; AGED; ANALYTIC METHOD; ANXIETY; ARTICLE; BODY MASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DYSPEPSIA; FUNCTION TEST; GASTROINTESTINAL SYMPTOM; HUMAN; HYPOTHESIS; NORMAL HUMAN; NUTRIENT DRINK TEST; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SYMPTOM;

ADULT; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CITALOPRAM; DESIPRAMINE; DIETARY SUCROSE; DOUBLE-BLIND METHOD; DYSPEPSIA; FEMALE; GASTRIC EMPTYING; HUMANS; MALE; POSTPRANDIAL PERIOD; TREATMENT OUTCOME;

EID: 27144549277     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000088363     Document Type: Article

References (22)

1. Talley N: Dyspepsia: management guidelines for the millenium. Gut 2002;50(suppl 4):iv72-iv79.
2. Camilleri M, Talley NJ: Pathophysiology as a basis for understanding symptom complexes and therapeutic targets. Neurogastroenterol Motil 2004;16:135-142.
3. Jackson JL, O'Malley PG, Tomkins G, Balden E, Santoro J, Kroenke K: Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am J Med 2000;108:65-72.
4. Mertz H, Fass R, Kodner A, Yan-Go F, Fullerton S, Mayer EA: Effect of amitriptyline on symptoms, sleep, and visceral perception in patients with functional dyspepsia. Am J Gastroenterol 1998;93:160-165.
5. Drossman D, Toner BB, Whitehead WE, Diamant NE, Dalton CB, Duncan S, Emmott S, Proffitt V, Akman D, Frusciante K, Le T, Meyer K, Bradshaw B, Mikula K, Morris CB, Blackman CJ, Hu Y, Jia H, Li JZ, Koch GG, Bangdiwala SI: Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterology 2003;125:19-31.
6. Chial HJ, Camilleri M, Burton D, Thomforde G, Olden KW, Stephens D: Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. Am J Physiol Gastrointest Liver Physiol 2003;284:G130-G137.
7. Creed F, Fernandes L, Guthrie E, Palmer S, Ratcliffe J, Read N, Rigby C, Thompson D, Tomenson B: The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome. Gastroenterology 2003;124:303-317.
8. Tack J, Broekaert D, Coulie B, Fischler B, Janssens J: Influence of the selective serotonin re-uptake inhibitor, paroxetine, on gastric sensorimotor function in humans. Aliment Pharmacol Ther 2003;17:603-608.
9. Boeckxstaens GE, Hirsch DP, van den Elzen BD, Heisterkamp SH, Tytgat GN: Impaired drinking capacity in patients with functional dyspepsia: relationship with proximal stomach function. Gastroenterology 2001;121:1054-1063.
10. Chial HJ, Camilleri C, Delgado-Aros S, Burton D, Thomforde G, Ferber I, Camilleri M: A nutrient drink test to assess maximum tolerated volume and postprandial symptoms: effects of gender, body mass index and age in health. Neurogastroenterol Motil 2002;14:249-253.
11. Delgado-Aros S, Cremonini F, Castillo JE, Chial HJ, Burton DD, Ferber I, Camilleri M: Independent influences of body mass and gastric volumes on satiation in humans. Gastroenterology 2004;126:432-440.
12. Tack J, Caenepeel P, Piessevaux H, Cuomo R, Janssens J: Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia. Gut 2003;52:1271-1277.
13. Delgado-Aros S, Chial HJ, Burton DD, McKinzie S, Ferber I, Camilleri M: Reliability of the nutrient drink test to assess maximum volume intake and postprandial symptoms. Gastroenterology 2002;122:A-550.
14. Talley NJ, Phillips SF, Melton J 3rd, Wiltgen C, Zinsmeister AR: A patient questionnaire to identify bowel disease. Ann Intern Med 1989;111:671-674.
15. Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361-370.
16. Einarson TR: Evidence based review of escitalopram in treating major depressive disorder in primary care. Int Clin Psychopharmacol 2004;19:305-310.
17. Broekaert D, Vos R, Gevers A-M, Janssens J, Vandenberghe J, Fischler B, Tack J: A double-blind randomized placebo-controlled cross-over trial of citalopram, a selective 5-hydroxy-tryptamine reuptake inhibitor in irritable bowel syndrome. Gastroenterology 2001;120:A641.
18. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J: Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115:1346-1352.
19. Kuo B, Camilleri M, Burton D, Viramontes B, McKinzie S, Thomforde G, O'Connor MK, Brinkmann BH: Effects of 5-HT(3) antagonism on postprandial gastric volume and symptoms in humans. Aliment Pharmacol Ther 2002;16:225-233.
20. Gonenne J, Castillo EJ, Camilleri M, Burton D, Thomforde G, Baxter K, Zinsmeister A: Does the nutrient drink test accurately predict postprandial gastric volume in health and community dyspepsia? Neurogastroenterol Motil 2005;17:44-50.
21. Jones MP, Hoffman S, Shah D, Patel K, Ebert CC: The water load test: observations from healthy controls and patients with functional dyspepsia. Am J Physiol Gastrointest Liver Physiol 2003;284:G896-G904.
22. Tabas G, Beaves M, Wang J, Friday P, Mardini H, Arnold G: Paroxetine to treat irritable bowel syndrome not responding to high-fiber diet: a double-blind, placebo-controlled trial. Am J Gastroenterol 2004;99:914-920.