Conjugated linoleic acid increased C-reactive protein in human subjects

British Journal of Nutrition

Volumn 94, Issue 5, 2005, Pages 791-795

  Smedman, Annika ^a   Basu, Samar ^a   Jovinge, Stefan ^b   Fredrikson, Gunilla Nordin ^b   Vessby, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

C reactive protein; Conjugated linoleic acid; Inflammation; Tumour necrosis factor

Indexed keywords

C REACTIVE PROTEIN; CONJUGATED LINOLEIC ACID; OLIVE OIL; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 2; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE;

ADULT; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; DINOPROST; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLAMMATION; LINOLEIC ACIDS, CONJUGATED; MALE; MIDDLE AGED; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; REGRESSION ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 27144541775     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1079/BJN20041419     Document Type: Article

References (37)

1. Albers R, van der Wielen RP, Brink EJ, Hendriks HF, Dorovska-Taran VN & Mohede IC (2003) Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur J Clin Nutr 57, 595-603.
2. Basu S (1998) Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2alpha: an index for inflammation via cyclooxygenase catalysed lipid peroxidation. Prostaglandins Leukot Essent Fatty Acids 58, 347-352.
3. Basu S (2003) Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology 189, 113-127.
4. Basu S, Risérus U, Turpeinen A & Vessby B (2000a) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin Sci 99, 511-516.
5. Basu S, Smedman A & Vessby B (2000b) Conjugated linoleic acid induces lipid peroxidation in human subjects. FEBS Lett 468, 33-36.
6. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein I & Gudmundsen O (2000) Conjugated linoleic acid reduces body fat mass in overweight and obese human subjects. J Nutr 130, 2943-2948.
7. Dichtl W, Ares MP, Jonson AN, Jovinge S, Pachinger O, Giachelli CM, Hamsten A, Eriksson P & Nilsson J (2002) Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-kappaB activation. Metabolism 51, 327-333.
8. Forouhi NG, Sattar N & McKeigue PM (2001) Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians. Int J Obes Relat Metab Disord 25, 1327-1331.
9. Grimble RF (2002) Inflammatory status and insulin resistance. Curr Opin Clin Nutr Metab Care 5, 551-559.
10. Grundy SM (2003) Inflammation, metabolic syndrome, and diet responsiveness. Circulation 108, 126-128.
11. Hauner H, Bender M, Haastert B & Hube F (1998) Plasma concentrations of soluble TNF-alpha receptors in obese subjects. Int J Obes Relat Metab Disord 22, 1239-1243.
12. Hotamisligil GS, Arner P, Atkinson RL & Spiegelman BM (1997) Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46, 451-455.
13. Hotamisligil GS, Arner P, Caro JF, Atkinson RL & Spiegelman BM (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95, 2409-2415.
14. Kelley DS, Taylor PC, Rudolph IL, Benito P, Nelson GJ, Mackey BE & Erickson KL (2000) Dietary conjugated linoleic acid did not alter immune status in young healthy women. Lipids 35, 1065-1071.
15. Kelly GS (2001) Conjugated linoleic acid: a review. Altern Med Rev 6, 367-382.
16. Krieglstein CF & Granger DN (2001) Adhesion molecules and their role in vascular disease. Am J Hypertens 14, 44S-54S.
17. Lind L (2003) Circulating markers of inflammation and atherosclerosis. Atherosclerosis 169, 203-214.
18. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW & Medford RM (1993) Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 92, 1866-1874.
19. Mohamed-Ali V, Goodrick S, Bulmer K, Holly JM, Yudkin JS & Coppack SW (1999) Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo. Am J Physiol 277, E971-E975.
20. Mougios V, Matsakasa A, Petridoua A, Ringb S, Sagredosc A, Melissopouloua A, Tsigilisa N & Nikolaidis M (2001) Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J Nutr Biochem 12, 585-594.
21. Nilsson J, Jovinge S, Niemann A, Reneland R & Lithell H (1998) Relation between plasma tumor necrosis factor-alpha and insulin sensitivity in elderly men with non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol 18, 1199-1202.
22. Pasceri V, Willerson JT & Yeh ET (2000) Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102, 2165-2168.
23. Ridker PM (2003) Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107, 363-369.
24. Ridker PM, Boring JE, Cook NR & Rifai N (2003) C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 107, 391-397.
25. Ridker PM, Cushman M, Stampfer MJ, Tracy RP & Hennekens CH (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336, 973-979.
26. Risérus U, Arner P, Brismar K & Vessby B (2002a) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25, 1516-1521.
27. Risérus U, Basu S, Jovinge S, Fredrikson G, Ärnlöv J & Vessby B (2002b) Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation 106, 1925-1929.
28. Risérus U, Berglund L & Vessby B (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord 25, 1129-1135.
29. Risérus U, Smedman A, Basu S & Vessby B (2004a) Metabolic effects of conjugated linoleic acid in human subjects: the Swedish experience. Am J Clin Nutr 79, 1146S-1148S.
30. Risérus U, Vessby B, Ärnlöv J & Basu S (2004b) Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 80, 279-283.
31. Sethi JK & Hotamisligil GS (1999) The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol 10, 19-29.
32. Smedman A & Vessby B (2001) Conjugated linoleic acid supplementation in human subjects - metabolic effects. Lipids 36, 773-781.
33. Smedman A, Vessby B & Basu S (2004) Isomer-specific effects of conjugated linoleic acid on lipid peroxidation in human subjects: regulation by alpha-tocopherol and cyclo-oxygenase-2 inhibitor. Clin Sci (Lond) 106, 67-73.
34. Turek JJ, Li Y, Schoenlein IA, Allen KGD & Watkins BA (1998) Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio. J Nutr Biochem 9, 258-266.
35. Van Lente F (2000) Markers of inflammation as predictors in cardiovascular disease. Clin Chim Acta 293, 31-52.
36. Yu Y, Correll PH & Vanden Heuvel JP (2002) Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim Biophys Acta 1581, 89-99.
37. Zambell KL, Keim NL, Van Loan MD, Gale B, Benito P, Kelley DS & Nelson GJ (2000) Conjugated linoleic acid supplementation in human subjects: effects on body composition and energy expenditure. Lipids 35, 777-782.