A high peritoneal large pore fluid flux causes hypoalbuminaemia and is a risk factor for death in peritoneal dialysis patients

Nephrology Dialysis Transplantation

Volumn 20, Issue 10, 2005, Pages 2194-2201

  Heaf, J G ^a,b   Sarac, S ^a   Afzal, S ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b NONE   (Denmark)

Author keywords

Hypoalbuminaemia; Peritoneal dialysis; Peritoneal transport

Indexed keywords

AQUAPORIN; CREATININE; SERUM ALBUMIN;

ADULT; AGED; ARTICLE; CIGARETTE SMOKING; COMORBIDITY; COMPUTER MODEL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HYPOALBUMINEMIA; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PERITONEAL DIALYSIS; PERITONEAL FLUID; PRIORITY JOURNAL; PROTEINURIA; RISK FACTOR; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TREATMENT FAILURE;

ADULT; AGED; BIOLOGICAL TRANSPORT, ACTIVE; DIALYSIS SOLUTIONS; FEMALE; HUMANS; HYPOALBUMINEMIA; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PERITONEAL DIALYSIS, CONTINUOUS AMBULATORY; PROGNOSIS; RISK FACTORS;

EID: 27144528350     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfi008     Document Type: Article

References (19)

1. Heaf JG. CAPD adequacy and dialysis morbidity: Detrimental effect of a high peritoneal equilibration rate. Renal Failure 1995; 17: 575-587
2. Churchill DN, Thorpe KE, Nolph KD, Keshaviah PR, Oreopoulos DG, Page D. Increased peritoneal membrane transport is associated with decreased patient and technique survival for continuous peritoneal dialysis patients. J Am Soc Nephrol 1998; 9: 1285-1292
3. Cooper S, Iliescu EA, Morton AR. The relationship between dialysate protein loss and membrane transport status in peritoneal dialysis patients. Adv Perit Dial 2001; 17: 244-247
4. Chung SH, Heimburger O, Stenvinkel P, Bergström. Association between inflammation and changes in residual renal function and peritoneal transport rate during the first year of dialysis. Nephrol Dial Transplant 2001; 16: 2240-2245
5. Pecoits-Filho R, Araújo MRT, Lindholm B et al. Plasma and dialysate IL-6 and VEGF concentrations are associated with high peritonea] solute transport rate. Nephrol Dial Transplant 2002; 17: 1480-1486
6. Rippe B. A three-pore model of peritoneal transport. Perit Dial Int 1993; 13 [Suppl 2]: S35-S38
7. Rippe B. Haraldsson B. Transport of macromolecules across microvascular walls: The two-pore theory. Physiol Rev 1994; 74: 163-219
8. Haraldsson B. Assessing the peritoneal dialysis capacities of individual patients. Kidney Int 1995; 47: 1187-1198
9. Blake PG. Comparison between DOQI and Canadian guidelines for peritoneal dialysis. Perit Dial Int 2000; 20: 487-492
10. Heaf JG. High Transport and Malnutrition-Inflammation-Atherosclerosis (MIA) Syndrome. Perit Dial Int 2003; 23: 109-110
11. Prinsen BHCMT, Rabelink TJ, Beutler JJ et al. Increased albumin and fibrinogen synthesis rate in patients with chronic renal failure. Kidney Int 2003; 64: 1495-1504
12. Aguilera A, Sanchez-Tomero JA, Bajo MA et al. Malnutrition-inflammation syndrome is associated with endothelial dysfunction in peritonea] dialysis patients. Adv Perit Dial 2003; 19: 240-245
13. Kim SB, Yang WS, Park JS. Role of hypoalbuminemia in the genesis of cardiovascular disease in dialysis patients. Perit Dial Int 1999; 19 [Suppl 2]: S144-S149
14. Heaf JG. Pathogenic effects of high peritoneal transport. Semin Dial 2000; 13: 188-193
15. Eknoyan G, Beck GJ, Cheung AK et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 2002; 347: 2010-2019
16. Paniagua R, Amato D, Vonesh E et al. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial. J Am Soc Nephrol 2002; 13: 1307-1320
17. Cueto-Manzano AM, Gamba G, Correa-Rotter R. Quantification and characterization of protein loss in continuous ambulatory peritoneal dialysis. Rev Invest Clin 2000; 52: 611-617
18. Cueto-Manzano AM, Gamba G, Correa-Rotter R. Peritoneal protein loss in patients with high peritoneal permeability: Comparison between continuous ambulatory peritoneal dialysis and daytime intermittent peritoneal dialysis. Arch Med Research 2001; 32: 197-201
19. Sjøland JA, Pedersen RS, Jespersen J, Gram J. Intraperitoneal heparin reduces peritoneal permeability and increases ultra-filtration in peritoneal dialysis patients. Nephrol Dial Transplant 2004; 19: 1264-1268