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Volumn 8, Issue 7, 2005, Pages 649-653

The design, synthesis and screening of a muscarinic acetylcholine receptor targeted compound library

Author keywords

Insecticide; Muscarinergic; Muscarinic acetylcholine receptor agonist; Oxime ether library

Indexed keywords

ISOXAZOLE DERIVATIVE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; THIADIAZOLE DERIVATIVE;

EID: 27144525580     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620705774575328     Document Type: Article
Times cited : (6)

References (14)
  • 7
    • 27144494163 scopus 로고    scopus 로고
    • note
    • We wish to thank Dr. E. Wojtech of Bayer CropScience for this electrophysiological test result. Potential muscarinic substances were assessed by measurement of the spontaneous electrical activity of a thoracic ganglion from a lepidopteran larvae, Spodoptera littoralis, bathed in an artificial physiological medium. Muscarinic agonists produced hyperactivity of the insect ganglion which could be specifically inhibited by the muscarinic antagonist Quinuclidinylbenzylate (QNB). Muscarinic antagonists produced no hyperexitation of the insect ganglion but did inhibit hyperexitation induced by the muscarinic agonist Muscarine. The effects were dose dependent.
  • 9
    • 27144558203 scopus 로고    scopus 로고
    • note
    • It was subsequently shown that the aldol condenation had occurred during storage of the piperidine 6 prior to its use in the library synthesis. Repeating the chemistry using freshly purified piperidine 6 yielded the desired oxime ether products with purity >85%
  • 11
    • 27144538000 scopus 로고    scopus 로고
    • 29851 Willow Creek Road, Eugene, OR 97402, U.S.A.
    • Molecular Probes Inc., 29851 Willow Creek Road, Eugene, OR 97402, U.S.A. See http://www.probes.com
  • 12
    • 27144547096 scopus 로고    scopus 로고
    • One Roundhouse Plaza, Northampton, MA 01060, U.S.A.
    • OriginLab Corporation, One Roundhouse Plaza, Northampton, MA 01060, U.S.A. See http://www.originlab.com
  • 13
    • 27144441961 scopus 로고    scopus 로고
    • PCT Int. Appl. WO 01 15, 532-A1, 2001
    • Lindell, S.; Sanft U.; Thönessen, M. PCT Int. Appl. WO 01 15, 532-A1, 2001 (Chem. Abstr., 2001, 134, 203794).
    • (2001) Chem. Abstr. , vol.134 , pp. 203794
    • Lindell, S.1    Sanft, U.2    Thönessen, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.