-
1
-
-
0037903823
-
Darstellung der reinen Mohnsäure (Opiumsäure) nebst einer chemischen Untersuchung des Opiums
-
1.Stück
-
Sertürner, (F.), Darstellung der reinen Mohnsäure (Opiumsäure) nebst einer chemischen Untersuchung des Opiums. Journal der Pharmacie 14 (1.Stück) (1805) 47-93.
-
(1805)
Journal der Pharmacie
, vol.14
, pp. 47-93
-
-
Sertürner, F.1
-
2
-
-
0036372023
-
Zwischen "Strafe Gottes" und "Göttlichem Werk". Historisches zum thema schmerz und schmerztherapie
-
Kuhlen, F.-J., Zwischen "Strafe Gottes" und "Göttlichem Werk". Historisches zum Thema Schmerz und Schmerztherapie. Pharm. uns. Z. 31 (2002) 13-22.
-
(2002)
Pharm. Uns. Z.
, vol.31
, pp. 13-22
-
-
Kuhlen, F.-J.1
-
3
-
-
27144528035
-
Die entdeckung des morphins
-
Friedrich, C., Die Entdeckung des Morphins. Dtsch. Apoth. Ztg. 145 (2005) 1176-1182.
-
(2005)
Dtsch. Apoth. Ztg.
, vol.145
, pp. 1176-1182
-
-
Friedrich, C.1
-
4
-
-
27144533372
-
Stark wirksame schmerzmittel ohne kritische nebenwirkungen: Ist das möglich?
-
Holzgrabe, U., Projahn, H., Ulmer, D., Stark wirksame Schmerzmittel ohne kritische Nebenwirkungen: Ist das möglich? Pharm. Ztg. 148 (2003) 1345-1351.
-
(2003)
Pharm. Ztg.
, vol.148
, pp. 1345-1351
-
-
Holzgrabe, U.1
Projahn, H.2
Ulmer, D.3
-
5
-
-
0023180221
-
Norcoclaurine as biosynthetic precursor of thebaine and morphine
-
Loeffler, S., Norcoclaurine As Biosynthetic Precursor of Thebaine and Morphine. J. Chem. Soc. Chem. Commun. (1987) 1160-1162.
-
(1987)
J. Chem. Soc. Chem. Commun.
, pp. 1160-1162
-
-
Loeffler, S.1
-
6
-
-
0029140430
-
S-Adenosyl-L-methionine: (S)-coclaurine-N-methyl-transferase from Tinospora cordifolia
-
Loeffler, S., Deus-Neumann, B., Zenk, M. H., S-Adenosyl-L-methionine: (S)-coclaurine-N-methyl-transferase from Tinospora cordifolia. Phytochemistry 38 (1995) 1387-1395.
-
(1995)
Phytochemistry
, vol.38
, pp. 1387-1395
-
-
Loeffler, S.1
Deus-Neumann, B.2
Zenk, M.H.3
-
7
-
-
0347317979
-
(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum-cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis
-
Ounaroon, A., et al., (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum-cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis. Plant J. 36 (2003) 808-819.
-
(2003)
Plant J.
, vol.36
, pp. 808-819
-
-
Ounaroon, A.1
-
8
-
-
0001161077
-
The hydroxylation step in the biosynthetic pathway leading from norcoclaurine to reticuline
-
Loeffler, S., Zenk, M. H., The hydroxylation step in the biosynthetic pathway leading from norcoclaurine to reticuline. Phytochemistry 29 (1990) 3499-3503.
-
(1990)
Phytochemistry
, vol.29
, pp. 3499-3503
-
-
Loeffler, S.1
Zenk, M.H.2
-
9
-
-
2142751582
-
1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinane biosynthetic pathway
-
Hirata, K., et al., 1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinane biosynthetic pathway. Phytochemistry 65 (2004) 1039-1046.
-
(2004)
Phytochemistry
, vol.65
, pp. 1039-1046
-
-
Hirata, K.1
-
10
-
-
20344383308
-
Purification and Properties of 1,2-Dehydroreticuline reductase from Papaver somniferum seedlings
-
De-Eknamkul, W., Zenk, M. H., Purification and Properties of 1,2-Dehydroreticuline reductase from Papaver somniferum seedlings. Phytochemistry 31 (1992) 813-821.
-
(1992)
Phytochemistry
, vol.31
, pp. 813-821
-
-
De-Eknamkul, W.1
Zenk, M.H.2
-
11
-
-
0025826559
-
Formation of the morphine precursor salutaridine is catalyzed by a cytochrom P-450 enzyme in mammalian liver
-
Amann, T., Zenk, M. H., Formation of the morphine precursor salutaridine is catalyzed by a cytochrom P-450 enzyme in mammalian liver. Tetrahedron Lett. 32 (1991) 3675-3678.
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 3675-3678
-
-
Amann, T.1
Zenk, M.H.2
-
12
-
-
44049113918
-
Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum
-
Gerardy, R., Zenk, M. H., Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum. Phytochemistry 32 (1992) 79-86.
-
(1992)
Phytochemistry
, vol.32
, pp. 79-86
-
-
Gerardy, R.1
Zenk, M.H.2
-
13
-
-
0000613388
-
Purification and characterization of salutaridine: NADPH 7-oxidoreductase from Papaver somniferum
-
Gerardy, R., Zenk, M. H., Purification and characterization of salutaridine: NADPH 7-oxidoreductase from Papaver somniferum. Phytochemistry 34 (1993) 125-132.
-
(1993)
Phytochemistry
, vol.34
, pp. 125-132
-
-
Gerardy, R.1
Zenk, M.H.2
-
14
-
-
0028245117
-
Closure of the oxide bridge in the morphine biosynthesis
-
Lenz, R., Zenk, M. H., Closure of the oxide bridge in the morphine biosynthesis. Tetrahedron Lett. 35 (1994) 3897-3900.
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 3897-3900
-
-
Lenz, R.1
Zenk, M.H.2
-
15
-
-
0029559296
-
Acetyl Coenzyme A: Salutaridinol-7-O-acetyltransferase from Papaver somniferum plant cell culture
-
Lenz, R., Zenk, M. H., Acetyl Coenzyme A: salutaridinol-7-O- acetyltransferase from Papaver somniferum plant cell culture. J. Biol. Chem. 270 (1995) 31091-31096.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 31091-31096
-
-
Lenz, R.1
Zenk, M.H.2
-
16
-
-
0015520397
-
Biosynthetic conversion of thebaine to codeine
-
Parker, H. I., Blaschke, G., Rapoport, H., Biosynthetic conversion of thebaine to codeine. J. Amer. Chem. Soc. 94 (1972) 1276-1282.
-
(1972)
J. Amer. Chem. Soc.
, vol.94
, pp. 1276-1282
-
-
Parker, H.I.1
Blaschke, G.2
Rapoport, H.3
-
17
-
-
0021123010
-
A second pathway for the terminal steps in the biosynthesis of morphine
-
Brochmann-Hanssen, E., A second pathway for the terminal steps in the biosynthesis of morphine. Planta Med. 51 (1984) 343-345.
-
(1984)
Planta Med.
, vol.51
, pp. 343-345
-
-
Brochmann-Hanssen, E.1
-
18
-
-
0030775837
-
Biotransformation of thebaine by cell cultures of Papaver somniferum and Mahonia nervosa
-
Wilhelm, R., Zenk, M. H., Biotransformation of thebaine by cell cultures of Papaver somniferum and Mahonia nervosa. Phytochemistry 46 (1997) 701-708.
-
(1997)
Phytochemistry
, vol.46
, pp. 701-708
-
-
Wilhelm, R.1
Zenk, M.H.2
-
19
-
-
0027209527
-
The transformation of neopinone to codeinone in morphine biosynthesis proceeds non-enzymatically
-
Gollwitzer, J., et al., The transformation of neopinone to codeinone in morphine biosynthesis proceeds non-enzymatically. Tetrahedron Lett. 34 (1993) 5703-5706.
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 5703-5706
-
-
Gollwitzer, J.1
-
20
-
-
0028938926
-
Stereoselective reduction of codeinone, the penultimate enzymatic step during morphine biosynthesis in Papaver somniferum
-
Lenz, R., Zenk, M. H., Stereoselective reduction of codeinone, the penultimate enzymatic step during morphine biosynthesis in Papaver somniferum. Tetrahedron Lett. 36 (1995) 2449-2452.
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 2449-2452
-
-
Lenz, R.1
Zenk, M.H.2
-
21
-
-
0010230544
-
Biosynthesis of Morphinan alkaloids
-
Philipson, J. D., Roberts, M. F., Zenk, M. H. (Hrsg.). Springer Verlag, Heidelberg
-
Brochmann-Hanssen, E., Biosynthesis of Morphinan alkaloids. In: Philipson, J. D., Roberts, M. F., Zenk, M. H. (Hrsg.), The Chemistry and Biology of Isoquinoline Alkaloids. Springer Verlag, Heidelberg 1985, S. 229-239.
-
(1985)
The Chemistry and Biology of Isoquinoline Alkaloids
, pp. 229-239
-
-
Brochmann-Hanssen, E.1
-
22
-
-
0030574271
-
Heterologous expression of alkaloid biosynthesis
-
Kutchan, T. M., Heterologous expression of alkaloid biosynthesis. Gene 179 (1996) 73-81.
-
(1996)
Gene
, vol.179
, pp. 73-81
-
-
Kutchan, T.M.1
-
23
-
-
26644468125
-
Comparative microarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in bisbenzylisoquinoline biosynthesis
-
in press
-
Ziegler, J., et al., Comparative microarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in bisbenzylisoquinoline biosynthesis. Planta (2005) in press.
-
(2005)
Planta
-
-
Ziegler, J.1
-
24
-
-
4644293708
-
Morphine-pathway block in top1 poppies
-
Millgate, A. G., et al., Morphine-pathway block in top1 poppies. Nature 431 (2004) 413-414.
-
(2004)
Nature
, vol.431
, pp. 413-414
-
-
Millgate, A.G.1
-
25
-
-
27144473535
-
Allgemeine und spezielle Pharmakologie und Toxikologie
-
Forth, W., et al., Allgemeine und spezielle Pharmakologie und Toxikologie. Urban & Fischer 2001.
-
(2001)
Urban & Fischer
-
-
Forth, W.1
-
26
-
-
0019890247
-
Morphine in cow and human milk: Could dietary morphine constitute a ligand for specific morphine (mu) receptors?
-
Hazum, E., et al., Morphine in cow and human milk: could dietary morphine constitute a ligand for specific morphine (mu) receptors? Science 213 (1981) 1010-1012.
-
(1981)
Science
, vol.213
, pp. 1010-1012
-
-
Hazum, E.1
-
27
-
-
0008320297
-
Isolation of morphine from toad skin
-
Oka, K., Kantrowitz, J. D., Spector, S., Isolation of morphine from toad skin. Proc. Nat. Acad. Sci. USA 82 (1986) 1852-1854.
-
(1986)
Proc. Nat. Acad. Sci. USA
, vol.82
, pp. 1852-1854
-
-
Oka, K.1
Kantrowitz, J.D.2
Spector, S.3
-
28
-
-
0010264512
-
Presence and formation of codeine and morphine in the rat
-
Donnerer, J., et al., Presence and formation of codeine and morphine in the rat. Proc. Nat. Acad. Sci. USA 83 (1986) 4566-4567.
-
(1986)
Proc. Nat. Acad. Sci. USA
, vol.83
, pp. 4566-4567
-
-
Donnerer, J.1
-
29
-
-
0000690734
-
Morphine and other opiates from beef brain and adrenal
-
Goldstein, A., et al., Morphine and other opiates from beef brain and adrenal. Proc. Nat. Acad. Sci. USA 82 (1985) 5203-5207.
-
(1985)
Proc. Nat. Acad. Sci. USA
, vol.82
, pp. 5203-5207
-
-
Goldstein, A.1
-
30
-
-
0032898330
-
Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range
-
Hofmann, U., et al., Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range. J. Chromatogr. B 727 (1999) 81-88.
-
(1999)
J. Chromatogr. B
, vol.727
, pp. 81-88
-
-
Hofmann, U.1
-
31
-
-
3042561691
-
13C-isotope biosynthetic labeling
-
13C-isotope biosynthetic labeling. Phytochemistry 65 (2004) 1413-1420.
-
(2004)
Phytochemistry
, vol.65
, pp. 1413-1420
-
-
Poeaknapo, C.1
-
32
-
-
4644225656
-
Endogenous formation of morphine in human cells
-
Poeaknapo, C., et al., Endogenous formation of morphine in human cells. Proc. Nat. Acad. Sci. USA 101 (2004) 14091-14096.
-
(2004)
Proc. Nat. Acad. Sci. USA
, vol.101
, pp. 14091-14096
-
-
Poeaknapo, C.1
-
33
-
-
20844440570
-
How human neuroblastoma cells make morphine
-
Boettcher, C., et al., How human neuroblastoma cells make morphine. Proc. Nat. Acad. Sci. USA 102 (2005) 8495-8500.
-
(2005)
Proc. Nat. Acad. Sci. USA
, vol.102
, pp. 8495-8500
-
-
Boettcher, C.1
-
35
-
-
0036170184
-
Gemischte opioide Agonisten/Antagonisten und partielle
-
Christoph, T., Buschmann, H., Gemischte opioide Agonisten/Antagonisten und partielle Agonisten. Pharm. uns. Z. 31 (2002) 40-43.
-
(2002)
Agonisten. Pharm. Uns. Z.
, vol.31
, pp. 40-43
-
-
Christoph, T.1
Buschmann, H.2
-
36
-
-
27144496264
-
Schmerz
-
Schneemann, H., Young, L. Y., Koda-Kimble, M. A. Springer-Verlag Heidelberg
-
Schneemann, H., Schmerz. In: Schneemann, H., Young, L. Y., Koda-Kimble, M. A., Angewandte Arzneimitteltherapie. Springer-Verlag Heidelberg 2001, S. 86-111.
-
(2001)
Angewandte Arzneimitteltherapie
, pp. 86-111
-
-
Schneemann, H.1
-
37
-
-
27144468843
-
-
Produktinformationen der Firma Grünenthal
-
Zaldiar®, Produktinformationen der Firma Grünenthal.
-
Zaldiar®
-
-
-
38
-
-
0036365250
-
Moderne darreichungsformen für opioide
-
Bartholomäus, J., Moderne Darreichungsformen für Opioide. Pharm. uns. Z. 31 (2002) 74-81.
-
(2002)
Pharm. Uns. Z.
, vol.31
, pp. 74-81
-
-
Bartholomäus, J.1
|