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Volumn 127, Issue 42, 2005, Pages 14833-14840

Biomimetic zinc funnel complexes based on Calix[6]N3ArO ligands: An acid-base switch for guest binding

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITY; AMINO ACIDS; BIOMIMETIC MATERIALS; ENZYMES; PHENOLS;

EID: 27144474903     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja053620e     Document Type: Article
Times cited : (37)

References (34)
  • 7
    • 84861986581 scopus 로고    scopus 로고
    • Messerschmidt, A., Bode, W., Cygler, M., Eds.; Wiley: Chichester
    • (e) Stöcker, W.; Yiallouros, I. In Handbook of metalloproteins; Messerschmidt, A., Bode, W., Cygler, M., Eds.; Wiley: Chichester, 2004; Vol. 3, pp 116.
    • (2004) Handbook of Metalloproteins , vol.3 , pp. 116
    • Stöcker, W.1    Yiallouros, I.2
  • 17
    • 27144556862 scopus 로고    scopus 로고
    • note
    • 3 ligands (see ref 11).
  • 20
    • 27144457274 scopus 로고    scopus 로고
    • note
    • 3 with only a few molar equivalents of MeCN.
  • 21
    • 27144474380 scopus 로고    scopus 로고
    • note
    • 2O and MeOH are good donors but lack a lipophilic chain. Therefore, they are not "good" guests (see refs 7, 8).
  • 22
    • 27144492538 scopus 로고    scopus 로고
    • note
    • An associative mechanism implying the coordination of a sixth ligand to zinc is highly unlikely, due to sterical overcrowding at the metal center in such an environment.
  • 32
    • 27144481874 scopus 로고    scopus 로고
    • note
    • Finally, in our proposed catalytic cycle, inactivation of the enzyme at low pH could stem from the protonation of the glutamate residue.
  • 33
    • 27144453232 scopus 로고    scopus 로고
    • note
    • Such a mechanism cannot be efficient in our calixarene-based system as the narrow rim of the macrocycle precludes the stabilization of a tetrahedral intermediate in the endo-position for sterical reasons.
  • 34
    • 27144548719 scopus 로고    scopus 로고
    • note
    • 2] = 0.2124. See Table S1 in the Supporting Information.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.