A combination atmospheric pressure LC/MS:GC/MS ion source: Advantages of dual AP-LC/MS:GC/MS instrumentation

Journal of the American Society for Mass Spectrometry

Volumn 16, Issue 11, 2005, Pages 1730-1738

  McEwen, Charles N ^a   McKay, Richard G ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC PRESSURE; COMPLEXATION; HYDROCARBONS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MIXTURES; MOLECULAR WEIGHT; VOLATILE ORGANIC COMPOUNDS;

CHROMATOGRAPHIC RESOLUTION; COMPLEX MIXTURE ANALYSIS; GC/MS; VOLTAGE FRAGMENTATION;

IONS;

ION;

ACCURACY; ARTICLE; ATMOSPHERIC PRESSURE; COMPUTER SYSTEM; ELECTRIC POTENTIAL; ELECTRON; GAS CHROMATOGRAPHY; GAS FLOW; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; VOLATILIZATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPLEX MIXTURES; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SYSTEMS INTEGRATION;

EID: 26944502726     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2005.07.005     Document Type: Article

References (34)

1. F.G. Kitson, B.S. Larsen, C.N. McEwen Gas Chromatography and Mass Spectrometry a Practical Guide 1996 Academic Press New York
2. T.L. Sheehan The best MS Option GC-MS and LC-MS Am. Lab. 2002 40 43 September
3. J.F. Felton GC and Systems Biology Today's Chemist at Work 13 2004 26 29
4. E.C. Horning, D.I. Carroll, I. Dzidic, K.D. Haegele, M.G. Horning, R.N. Stillwell Atmospheric Pressure Ionization Mass Spectrometry, Solvent-Mediated Ionization of Samples Introduced in Solution and in a Liquid Chromatograph Effluent System J. Chromatogr. Sci. 12 1974 725 729
5. C.M. Whitehouse, R.N. Dreyer, M. Yamashita, J.B. Fenn Electrospray Interface for Liquid Chromatographs and Mass Spectrometers Anal. Chem. 57 1985 675 679
6. D.I. Carroll, I. Dzidic, R.N. Stillwell, K.D. Haegele, E.C. Horning Atmospheric Pressure Ionization Mass Spectrometry Corona Discharge Ion Source for Use in a Liquid Chromatography-Mass Spectrometry-Computer Analytical System Anal. Chem. 47 1975 2369 2373
7. D.B. Robb, T.R. Covey, A.P. Bruins Atmospheric Pressure Photoionization An Ionization Method for Liquid Chromatography-Mass Spectrometry Anal. Chem. 77 2000 3653 3659
8. A. Cappiello, M. Balogh, G. Famiglini, F. Mangani, P. Palma An Efficient Liquid Chromatography-Mass Spectrometry Interface for the Generation of Electron Ionization Spectra Anal. Chem. 72 2000 3841 3846
9. E.C. Horning, M.G. Horning, D.I. Carroll, I. Dzidic, R.N. Stillwell New Picogram Detection System Based on a Mass Spectrometer with an External Ionization Source at Atmospheric Pressure Anal. Chem. 45 1973 936 943
10. E.C. Horning, D.I. Carroll, I. Dzidic, K.D. Haegele, S.-N. Lin, C.V. Oertil, R.N. Stillwell Development and Use of Analytical Systems Based on Mass Spectrometry Clin. Chem 23 1977 13 21
11. I. Dzidic, D.I. Carroll, R.N. Stillwell, E.C. Horning Comparison of Positive Ions formed in Nickel-63 and Corona Discharge Ion Sources Using Nitrogen, Argon, Isobutene, Ammonia, and Nitric Oxide as Reagents in Atmospheric Pressure Ionization Mass Spectrometry Anal. Chem. 48 1976 1763 1768
12. R.K. Mitchum, W.A. Korfmacher, G.F. Moler, D.L. Stalling Capillary Gas Chromatography/Atmospheric Pressure Negative Chemical Ionization Mass Spectrometry of 22 Isomeric Tetrachlorodibenzo-p-Dioxins Anal. Chem. 54 1982 719 722
13. R.K. Mitchum, G.F. Moler, W.A. Korfmacher Combined Capillary Gas Chromatography/Atmospheric Pressure Negative Chemical Ionization/Mass Spectrometry for the Determination of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Tissue Anal. Chem. 52 1980 2278 2282
14. W.A. Korfmacher, L.G. Rushing, R.J. Engelbach, J.P. Freeman, Z. Djuric, E.K. Fifer, F.A. Beland Analysis of Three Aminonitropyrene Isomers via Fused Silica Gas Chromatography Combined with Negative Ion Atmospheric Pressure Ionization Mass Spectrometry J. High Resolut. Chromatogr., Chromatogr. Commun 10 1987 43 45
15. W.A. Korfmacher, L.G. Rushing Analysis of Seven Nitronaphthalene Compounds via Fused Silica Gas Chromatography Combined with Negative Ion Atmospheric Pressure ionization Mass Spectrometry J. High Resolut. Chromatogr., Chromatogr. Commun. 9 1986 293 295
16. W.A. Korfmacher, L.G. Rushing, J. Arey, B. Zielinska, J.N. Pitts Jr. Identification of Mononitropyrenes and Mononitrofluoranthenes in Air Particulate Matter via Fused Silica Gas Chromatography Combined with Negative Ion Atmospheric Pressure Ionization Mass Spectrometry J. High Resolut. Chromatogr., Chromatogr. Commun. 10 1987 641 646
17. W.A. Korfmacher, K.R. Rowland, R.K. Mitchum, J.J. Daly, R.C. McDaniel, M.V. Plummer Analysis of Snake Tissue and Snake Eggs for 2,3,7,8- Tetrachlorodibenzo-p-Dioxan via Fused Silica GC Combined with Atmospheric Pressure Ionization MS Chemosphere 13 1984 1229 1233
18. W.A. Korfmacher, L.G. Rushing, J. Arey, B. Zielinska, J.N. Pitts Jr. Identification of Mononitropyrenes and Mononitrofluoranthenes in Air Particulate Matter via Fused Silica Gas Chromatography Combined with Negative Ion Atmospheric Pressure Ionization Mass Spectrometry J. High Resolut. Chromatogr., Chromatogr. Commun. 11 1988 288
19. R.J. Engelbach, W.A. Korfmacher, L.G. Rushing Analysis of Nitropyrenamines and Methylated Nitropyrenamines via Gas Chromatography-Negative Ion Atmospheric Pressure Mass Spectrometry J. High Resolut. Chromatogr., Chromatogr. Commun. 11 1988 661 663
20. T. Kinouchi, A.T.L. Miranda, L.G. Rushing, F.A. Beland, W.A. Korfmacher Detection of 2-Aminofluorene at Femtogram Levels via High-Resolution Gas Chromatography Combined with Negative Ion Atmospheric Pressure Ionization Mass Spectrometry J. High Resolut. Chromatogr., Chromatogr. Commun. 13 1990 281 284
21. R.K. Mitchum, W.A. Korfmacher, J.P. Freeman An Atmospheric Pressure Ionization Source for a Finnigan-MAT 4000 Mass Spectrometer Anal. Instrum. 15 1986 37 50
22. M.W. Siegal, M.C. McKeown Ions and Electrons in the Electron Capture Detector Quantitative Identification by Atmospheric Pressure Ionization Mass Spectrometry J. Chromatogr. 122 1976 397
23. N.M. Reid, J.A. Buckley, C.C. Pom, J.B. French Adv. Mass Spectrom. 8B 1980 1843
24. D.A. Lave, A.M. Thompson, A.M. Lovett, N.M. Reid Adv. Mass Spectrom. 8B 1980 1480
25. M.W. Siegal, W.I. Fite Terminal Ions in Weak Atmospheric Plasmas. Applications of Atmospheric Pressure Ionization to Trace Impurity Analysis in Gases J. Phys. Chem. 80 1976 2871 2881
26. L. Charles, L.S. Riter, R.G. Cooks Direct Analysis of Semivolatile Organic Compounds in Air by Atmospheric Pressure Chemical Ionization Mass Spectrometry J. Agric. Food Chem. 48 2000 5389 5395
27. A.P. Snyder, J.H. Kremer, H.L.C. Mouzelaar, W. Windig, K. Taghizahed Curie-Point Pyrolysis Atmospheric Pressure Chemical Ionization Mass Spectrometry Preliminary Performance Data for Three Biopolymers Anal. Chem. 59 1987 1945 1951
28. W.E. Steiner, B.H. Clowers, P.E. Haigh, H.H. Hill Secondary Ionization of Chemical Warfare Agent Simulants Atmospheric Pressure Ion Mobility Time-of-Flight Mass Spectrometry Anal. Chem. 75 2003 6068 6076
29. E. Nikolaev, L.S. Riter, B.C. Laughlin, E. Handberg, R.G. Cooks Trace Analysis of Organics in Air by Corona Discharge Atmospheric Pressure Ionization Using an Electrospray Ionization Interface Eur. J. Mass Spectrom. 1 2004 197 204
30. L.N. Tyrefors, R.X. Moulder, K.E. Markides Intrerface for Open Tubular Column Supercritical Fluid Chromatography/Atmospheric Pressure Chemical Ionization Mass Spectrometry Anal. Chem. 65 1993 2835 2840
31. P. Sandra, A. Medvedovici, Y. Ahao, F.J. David Characterization of Triglycerides in Vegetable Oils by Silver-Ion Packed-Column Supercritical Fluid Chromatography Coupled to Mass Spectroscopy with Atmospheric Pressure Chemical Ionization and Coordination Ion Spray J. Chromatogr. A 974 2002 231 241
32. K. Schmeer, G. Nicholson, S.G. Zhang, E. Bayer, K. Bohning-Gaese Identification of the Lipids and the Ant Attractant 1,2-Dioleoylglycerol in the Arils of Commiphora guillaumini Perr. (Burseraceae) by Supercritical Fluid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry J. Chromatogr. A 727 1996 139 146
33. W.A. Korfmacher, L.G. Rushing Determination of Seven Nitronapthalene Compounds via Fused Silica Gas Chromatography Combined with Negative Ion Atmospheric Pressure Ionization Mass Spectrometry J. High Resolut. Chromatogr., Chromatogr. Commun. 9 1986 293 295
34. P. Jonsson, J. Gullberg, A. Nordstrom, M. Kusano, M. Kowalczyk, M. Sjostrom, T. Moritz A Strategy for Identifying Differences in Large Series of Metabolomic Samples Analyzed by GC/MS Anal. Chem. 76 2004 1738 1745