Effects of preoperative administration of carprofen on renal function and hemostasis in dogs undergoing surger for fracture repair

American Journal of Veterinary Research

Volumn 66, Issue 8, 2005, Pages 1356-1363

  Bergmann, Hannes M L ^b   Nolte, Ingo J A ^a   Kramer, Sabine ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARPROFEN; CREATININE; DIAZEPAM; ISOFLURANE; LEVOMETHADONE; NITROUS OXIDE; OXYGEN; PROPOFOL; CARBAZOLE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANESTHESIA INDUCTION; ARTICLE; BIOCHEMISTRY; BLEEDING TIME; CONTROLLED STUDY; CREATININE URINE LEVEL; DOG; EXTUBATION; FEMALE; FRACTURE; GENERAL ANESTHESIA; GLOMERULUS FILTRATION RATE; HEMATOCRIT; HEMOSTASIS; KIDNEY FUNCTION TEST; MALE; NONHUMAN; ORTHOPEDIC SURGERY; PARTIAL THROMBOPLASTIN TIME; PREOPERATIVE CARE; PROTEIN URINE LEVEL; PROTHROMBIN TIME; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; URINALYSIS; VETERINARY MEDICINE; ANIMAL; ANIMAL DISEASE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOG DISEASE; DRUG EFFECT; INJURY; KIDNEY DISEASE; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL;

ANIMALIA; CANIS FAMILIARIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBAZOLES; DOG DISEASES; DOGS; FEMALE; FRACTURES, BONE; HEMOSTASIS; KIDNEY DISEASES; MALE; PAIN, POSTOPERATIVE;

EID: 26944494975     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.1356     Document Type: Article

References (54)

1. Mathews KA. Nonsteroidal anti-inflammatory analgesics in pain management in dogs and cats. Assessment of pain. Can Vet J 1996;37:539-545.
2. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971;231:232-235.
3. McCormack K, Brune K. Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal antiinflammatory drugs. A survey of their analgesic efficacy. Drugs 1991;41:533-547.
4. Malmgren AB, Yaksh TL. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 1992;257:1276-1279.
5. O'Brien WM, Bagby GF. Carprofen: a new nonsteroidal anti-inflammatory drug. Pharmacology, clinical efficacy and adverse effects. Pharmacotherapy 1987;7:16-24.
6. Vasseur PB, Johnson AL, Budsberg SC, et al. Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal anti-inflammatory drug, in the treatment of osteoarthritis. J Am Vet Med Assoc 1995;206:807-811.
7. Lascelles BD, Butterworth SJ, Waterman AE. Postoperative analgesic and sedative effects of carprofen and pethidine in dogs. Vet Rec 1994;134:187-191.
8. Lascelles BD, Cripps PJ, Jones A, et al. Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Vet Surg 1998;27:568-582.
9. Grisneaux E, Pibarot P, Dupuis J, et al. Comparison of ketoprofen and carprofen administered prior to orthopedic surgery for control of postoperative pain in dogs. J Am Vet Med Assoc 1999;215:1105-1110.
10. Nolan A, Reid J. Comparison of the postoperative analgesic and sedative effects of carprofen and papaveretum in the dog. Vet Rec 1993;133:240-242.
11. Kehlet H, Mather LE. The value of NSAID's in the management of postoperative pain. Drugs 1992;44:1-63.
12. Rubin SI. Nonsteroidal antiinflammatory drugs, prostaglandins, and the kidney. J Am Vet Met Assoc 1986;188:1065-1068.
13. Whelton A, Stout RL, Spilman PS, et al. Renal effects of ibuprofen, piroxicam and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison. Ann Intern Med 1990;112:568-576.
14. Ko JC, Miyabiyashi T, Mandsager RE, et al. Renal effects of carprofen administered to healthy dogs anesthetized with propofol and isoflurane. J Am Vet Med Assoc 2000;217:346-349.
15. Lobetti RG, Joubert KE. Effect of administration of non-steroidal anti-inflammatory drugs before surgery on renal function in clinically normal dogs. Am J Vet Res 2000;61:1501-1506.
16. Boström IM, Nyman GC, Lord PF, et al. Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia. Am J Vet Res 2002;63:712-721.
17. Schafer AI. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol 1995;35:209-219.
18. Lemke KA, Runyon CL, Horney BS. Effects of preoperative administration of ketoprofen on anesthetic requirements and signs of postoperative pain in dogs undergoing elective ovariohysterectomy. J Am Vet Med Assoc 2002;221:1268-1275.
19. McKellar QA, Pearson T, Bogan JA, et al. Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog. J Small Anim Pract 1990;31:443-448.
20. Hickford FH, Barr SC, Erb HN. Effect of carprofen on hemostatic variables in dogs. Am J Vet Res 2001;62:1642-1646.
21. Norman PH, Daley D, Lindsey RW. Preemptive analgesic effects of ketorolac in ankle fracture surgery. Anesthesiology 2001;94:599-603.
22. Rosenberg IK, Gupta SL, Lucas CE, et al. Renal insufficiency after trauma and sepsis. A prospective functional and ultrastructural analysis. Arch Surg 1971;103:175-183.
23. Bevan DR, Dudley HA, Horsey PJ. Renal function during and after anaesthesia and surgery: significance for water and electrolyte management. Br J Anaesth 1973;45:968-975.
24. Shin B, MacKenzie CF, McAslan TC, et al. Postoperative renal failure in trauma patients. Anesthesiology 1979;51:218-221.
25. Attar S, Boyd D, Layne E, et al. Alterations in coagulation and fibrinolytic mechanisms in acute trauma. J Trauma 1969; 9:939-965.
26. Lampl L, Bock KH, Hartel W, et al. Disorders of hemostasis after polytrauma. On the extent of intrinsic fibrinolytic activity in the preclinical phase [in German]. Chirurg 1992;63:305-309.
27. Baehner RL. Alterations in blood coagulation with trauma. Pediatr Clin North Am 1975;22:289-299.
28. Mischke R. Activated partial thromboplastin time as a screening test of minor or moderate coagulation factor deficiencies for canine plasma: sensitivity of different commercial reagents. J Vet Diagn Invest 2000;12:433-437.
29. Mischke R. Evaluation of a prothrombin time optimized for dogs on plasmas with defined coagulation factor deficiency due to coumarin intoxication. Zentralbl Veterinarmed [A] 1995; 42:589-599.
30. Iazbik C, Couto CG, Gray TL, et al. Effect of storage conditions on hemostatic parameters of canine plasma obtained for transfusion. Am J Vet Res 2001;62:734-735.
31. Nolte I, Niemann C, Bowry SK, et al. A method for measuring capillary bleeding time in non-anaesthetized dogs: prolongation of the bleeding time by acetylsalicylic acid. Zentralbl Veterinarmed [A] 1997;44:625-628.
32. Born GV. Aggregation of blood platelets by adenosine disphosphate and its reversal. Nature 1962;194:927-929.
33. Westhoff A, Meyer-Lindenberg A, Wohlsein P, et al. Messung der glomerulären Filtrationsrate (GFR) beim Hund mittels nichtradioaktiver Jod-Kontrastmittel Clearance durch den Renalyzer PRX 90. Mh Vet Med 1993;48:573-582.
34. Thomsen HS, Vestergaard A, Golman K, et al. One or two samples for determination of total plasma clearance of a nonionic contrast medium in patients undergoing enhanced CT. Acta Radiol 1992;33:588-591.
35. Finco DR, Braselton WE, Cooper TA. Relationship between plasma iohexol clearance and urinary exogenous creatinine clearance in dogs. J Vet Intern Med 2001;15:368-373.
36. Erley CM, Bader BD, Berger ED, et al. Gadolinium-based contrast media compared with iodinated media for digital subtraction angiography in azotaemic patients. Nephrol Dial Transplant 2004;19:2526-2531.
37. Shin B, MacKenzie CF, Helrich M. Creatinine clearance for early detection of posttraumatic renal dysfunction. Anesthesiology 1986;64:605-609.
38. Chew DJ, Dibartola SP. Diagnosis and pathophysiology of renal disease. In: Ettinger SJ, ed. Textbook of veterinary internal medicine. Philadelphia: WB Saunders Co, 1989;1893-1961.
39. Jones LW, Weil MH. Water, creatinine and sodium excretion following circulatory shock with renal failure. Am J Med 1971;51:314-318.
40. Lauson HD, Bradley SE, Cournand A. The renal circulation in shock. J Clin Invest 1944;23:381-402.
41. Nelson RW, Turnwald GH, Willard MD. Endocrine, metabolic, and lipid disorders. In: Willard MD, Tvedteh H, Turnwald GH, eds. Small animal clinical diagnosis by laboratory methods. 3rd ed. Philadelphia: WB Saunders Co, 1999;136-171.
42. Stoelting RK, Miller RD. Renal disease. In: Stoelting RK, Miller RD, eds. Basics of anesthesia. 3rd ed. New York: Churchill Livingstone Inc, 1994;301-314.
43. Papich MG. Principles of analgesic drug therapy. Semin Vet Med Surg (Small Anim) 1997;12:80-93.
44. Remuzzi G, Zoja C, Rossi EC. Prostacyclin in thrombotic mircroangiopathy. Semin Hematol 1987;24:110-118.
45. Reagan WJ, Rebar AH. Platelet disorders. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinary internal medicine. 4th ed. Philadelphia: WB Saunders Co, 1995;1964-1976.
46. Wilson D, Cooke EA, McNally MA, et al. Changes in coagulability as measured by thrombelastography following surgery for proximal femoral fracture. Injury 2001;32:765-770.
47. Neuhof H, Lasch HG. Shock, microcirculation and hemostasis. Dtsch Med Wochenschr 1970;95:1937-1942.
48. Johnstone IB. Clinical and laboratory diagnosis of bleeding disorders. Vet Clin North Am Small Anim Pract 1988; 18:21-33.
49. Barr SC, Ludders JW, Looney AL, et al. Platelet aggregation in dogs after sedation with acepromazine and atropine and during subsequent general anesthesia and surgery. Am J Vet Res 1992; 53:2067-2070.
50. Lampl L, Helm M, Specht A, et al. Blood coagulation parameters as prognostic factors in multiple trauma: can clinical values be an early diagnostic aid [in German]? Zentralbl Chir 1994; 119:683-689.
51. Panciera DL, Johnson SG. Plasma von Willebrand factor antigen concentration and buccal mucosal bleeding time in dogs with experimental hypothyroidism. J Vet Intern Med 1996;10:60-64.
52. Zawie D, Garvey MC. Feline hepatic disease. Vet Clin North Am Small Anim Pract 1984;14:1201-1230.
53. Taylor PM, Delatour P, Lanodone FM, et al. Pharmacodynamics and enantioselective pharmacokinetics of carprofen in the cat. Res Vet Sci 1996;60:144-151.
54. Lascelles BD, Cripps P, Mirchandani S, et al. Carprofen as an analgesic for postoperative pain in cats: dose titration and assessment of efficacy in comparison to pethidine hydrochloride. J Small Anim Pract 1995;36:535-541.