Embryotoxicity study of monomeric 4,4'-methylenediphenyl diisocyanate (MDI) aerosol after inhalation exposure in Wistar rats

Fundamental and Applied Toxicology

Volumn 32, Issue 1, 1996, Pages 96-101

  Buschmann, Jochen ^a   Koch, Wolfgang ^a   Fuhst, Rainer ^a   Heinrich, Uwe ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENYLMETHANE 4,4' DIISOCYANATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYOTOXICITY; INHALATION; NONHUMAN; RAT;

EID: 26944482812     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0111     Document Type: Article

References (26)

1. Agarwal, D. K., and Bose, M. (1992). Inhalation toxicity of methylisocyanate: Assessment of germ cell mutagenicity and reproductive effects in rats. Ind. J. Exp. Biol. 30, 504-508.
2. Bucher, J. R. (1987). Methyl isocyanate. A review of health effects research since Bhopal. Fundam. App. Toxicol. 9, 367-379.
3. Dearman, R. J., Basketter, D. A., and Kimber, I. (1992a). Variable effects of chemical allergens on serum IgE concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers. J. Appl. Toxicol. 12, 317-323.
4. Dearman, R. J., Spence, L. M., and Kimber, I. (1992b). Characterization of murine immune responses to allergenic diisocyanates. Toxicol. Appl. Pharmacol. 112, 190-197.
5. Guest, I., and Varma, D. R. (1991). Developmental toxicity of methylamines in mice. J. Toxicol. Environ. Health 32, 319-330.
6. Heinrich, U., Muhle, H., Koch, W., and Mohr, U. (1985). Long-term inhalation studies with rodents. In Safety Evaluation and Regulation of Chemicals (F. Homburger, Ed.), Vol. 2, pp. 239-250. Karger, Basel.
7. Heinrich, U., Koch, W., Schüler, T., Creutzenberg, O., Rittinghausen, S., Klingebiel, R., Hoymann, H. G., Bartsch, W., and Preiss, A. (1991). Inhalation exposure of rats to 4′,4-methylenediphenyl-diisocyanate (MDI). In Proceedings, BOHS VIIIth International Symposium on Inhaled Particles, Edinburgh, 1991, p. 6.8.
8. Hoymann, H. G., Ernst, H., Buschmann, J., and Heinrich, U. (1994). Examination of chronic-inhalational toxicity of an isocyanate (MDI). News Report of the Fraunhofer Institute of Toxicology and Aerosol Research, February 1994, pp. 4-5.
9. Kapoor, R. (1991). Fetal loss and contraceptive acceptance among the Bhopal gas victims. Social Biol. 38, 242-248.
10. Klingebiel, R., Creutzenberg, O., Hoymann, H. G., Dettmer, M., Schüler, T., and Heinrich, U. (1991). Effects of 12 weeks exposure to a diisocyanate (MDI) on the pulmonary surfactant system and bronchoalveolar cell content in rats. Eur. Respir. J. 4(Suppl. 14), 352s-353s.
11. Marczynski, B., Czuppon, A. B., Hoffarth, H. P., Marek, W., and Baur, X. (1992). DNA damage in human white blood cells after inhalative exposure to methylenediphenyl diisocyanate (MDI) - Case report. Toxicol. Lett. 60, 131-138.
12. Martin-Carrera, I., Klingebiel, R., Hoymann, H. G., and Heinrich, U. (1991). Effects of subchronic exposure to a diisoyanate (MDI) on the pulmonary surfactant system and lung function. J. Aerosol Med. 4, 35.
13. Nehez, M., Fischer, G. W., Nehez, I., and Desi, I. (1989). Investigations on the acute toxic, cytogenetic, and embryotoxic activity of phenyl isocyanate and diethoxyphosphoryl isocyanate. Ecotoxicol. Environ. Safety 17, 258-263.
14. Palmer, A. K. (1977). Incidence of sporadic malformations, anomalies and variations in random bred laboratory animals. In Methods in Prenatal Toxicology (D. Neubert, H.-J. Merker, and T. E. Kwasigroch, Eds.), pp. 52-71. Thieme, Stuttgart.
15. Palmer, A. K. (1980). Teratology and safety evaluation. In The Principles and Methods in Modern Toxicology (C. L. Galli, S. D. Murphy, and R. Paoletti, Eds.), pp. 139-157. Elsevier/North-Holland, Amsterdam.
16. Pauluhn, J., and Mohr, U. (1994). Assessment of respiratory hypersensitivity in guinea-pigs sensitized to diphenylmethane-4,4′-diisocyanate (MDI) and challenged with MDI, acetylcholine or MDI-albumin conjugate. Toxicology 92, 53-74.
17. Rattray, N. J., Botham, P. A., Hext, P. M., Woodcock, D. R., Fielding, I., Dearman, R. J., and Kimber, I. (1994). Induction of respiratory hypersensitivity to diphenylmethane-4,4′-diisocyanate (MDI) in guinea pigs. Influence of route of exposure. Toxicology 88, 15-30.
18. Reidy, T. J., and Bolter, J. F. (1994). Neuropsychological toxicology of methylene diphenyl diisocyanate: A report of five cases. Brain Inj. 8, 285-294.
19. Reuzel, P. G., Arts, J. H., Lomax, L. G., Kuijpers, M. H., Kuper, C. F., Gembardt, C., Feron, V. J., and Loser, E. (1994a). Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats. Fundam. Appl. Toxicol. 22, 195-210.
20. Reuzel, P. G., Kuper, C. F., Feron, V. J., Appelman, L. M., and Loser, E. (1994b). Acute, subacute, and subchronic inhalation toxicity studies of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats. Fundam. Appl. Toxicol. 22, 186-194.
21. Schwetz, B. A., Adkins, B., Jr., Harris, M., Moorman, M., and Sloane, R. (1987). Methyl isocyanate: Reproductive and developmental toxicology studies in Swiss mice. Environ. Health Perspect. 72, 149-152.
22. Shilotri, N. P., Raval, M. Y., and Hinduja, I. N. (1986). Gynaecological and obstetrical survey of Bhopal women following exposure to methyl isocyanate. J. Postgrad. Med. 32, 203-205.
23. Varma, D. R. (1987). Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy. Environ. Health Perspect. 72, 153-157.
24. Varma, D. R., Ferguson, J. S., and Alarie, Y. (1987). Reproductive toxicity of methyl isocyanate in mice. J. Toxicol. Environ. Health 21, 265-275.
25. Varma, D. R., Guest, I., Smith, S., and Mulay, S. (1990). Dissociation between maternal and fetal toxicity of methyl isocyanate in mice and rats. J. Toxicol. Environ. Health 30, 1-14.
26. Wilson, J. G. (1965). Embryological considerations in teratology. In Teratology: Principles and Techniques (J. G. Wilson and J. Warkany, Eds.), pp. 251-278. Univ. of Chicago Press, Chicago/London.