Assessment of the genetic risk and impact of lateral transmission in a valine-associated scrapie outbreak in sheep

American Journal of Veterinary Research

Volumn 66, Issue 8, 2005, Pages 1302-1307

  Evoniuk, Jessica M ^a   Stoltenow, Charles L ^a   O'Rourke, Katherine I ^b   Moore, Bert L ^a   Redmer, Dale A ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

^b AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VALINE;

ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CODON; CONTROLLED STUDY; CORRELATION ANALYSIS; DIPLOIDY; DISEASE TRANSMISSION; EPIDEMIC; GENE FREQUENCY; GENETIC RISK; GENOTYPE; IMMUNOHISTOCHEMISTRY; NONHUMAN; RISK ASSESSMENT; SCRAPIE; SEMEN ANALYSIS; SHEEP DISEASE; UNITED STATES; AMINO ACID SUBSTITUTION; ANIMAL; ANIMAL DISEASE; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; PRION; SHEEP;

ANIMALIA; OVIS ARIES;

AMINO ACID SUBSTITUTION; ANIMALS; DISEASE OUTBREAKS; DISEASE TRANSMISSION, HORIZONTAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; MALE; PRIONS; SCRAPIE; SHEEP; VALINE;

EID: 26944472100     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.1302     Document Type: Article

References (23)

1. Prusiner SB. Prions. Proc Natl Acad Sci U S A 1998;95:13363-13383.
2. Baylis M, Houston F, Goldmann W, et al. The signature of scrapie: differences in the PrP genotype profile of scrapie-affected and scrapie-free UK sheep flocks. Proc R Soc Lond B Biol Sci 2000; 267:2029-2035.
3. Goldmann W, Hunter N, Smith G, et al. PrP genotypes and the Sip gene in Cheviot sheep form the basis for scrapie strain typing in sheep. Ann N Y Acad Sci 1994;724:296-299.
4. Baylis M, Goldmann W. The genetics of scrapie in sheep and goats. Curr Mol Med 2004;4:385-396.
5. Belt PB, Muileman IH, Schreuder BE, et al. Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie. J Gen Virol 1995;76:509-517.
6. Hunter N, Foster JD, Goldmann W, et al. Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes. Arch Virol 1996;141:809-824.
7. Hunter N, Goldmann W, Smith G, et al. The association of a codon 136 PrP gene variant with the occurrence of natural scrapie. Arch Virol 1994;137:171-177.
8. Hunter N, Moore L, Hosie BD, et al. Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland. Vet Rec 1997;140:59-63.
9. Ikeda T, Horiuchi M, Ishiguro N, et al. Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in Japan. J Gen Virol 1995;76:2577-2581.
10. O'Rourke KI, Melco RP, Mickelson JR. Allelic frequencies of an ovine scrapie susceptibility gene. Anim Biotechnol 1996;7:155-162.
11. Westaway D, Zuliani V, Cooper CM, et al. Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie. Genes Dev 1994;8:959-969.
12. Hoinville LJ. A review of the epidemiology of scrapie in sheep. Rev Sci Tech 1996;15:827-852.
13. Pattison IH, Hoare MN, Jebbett JN, et al. Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep. Vet Rec 1972;90:465-468.
14. Ryder S, Dexter G, Bellworthy S, et al. Demonstration of lateral transmission of scrapie between sheep kept under natural conditions using lymphoid tissue biopsy. Res Vet Sci 2004;76:211-217.
15. Tuo W, Zhuang D, Knowles DP, et al. PrP-C and PrP-Sc at the fetal-maternal interface. J Biol Chem 2001;276:18229-18234.
16. Tuo W, O'Rourke KI, Zhuang D, et al. Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep. Proc Natl Acad Sci U S A 2002; 99:6310-6315.
17. Andreoletti O, Lacroux C, Chabert A, et al. PrPSc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission. J Gen Virol 2002;83:2607-2616.
18. Diaz C, Vitezica ZG, Rupp R, et al. Polygenic variation and transmission factors involved in the resistance/susceptibility to scrapic in a Romanov flock. J Gen Virol 2005;86:849-857.
19. O'Rourke KI, Baszler TV, Besser TE, et al. Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissue. J Clin Microbiol 2000;38:3254-3259.
20. Agresti A. Categorical data analysis. 2nd ed. Hoboken, NJ: John Wiley & Sons, 2002.
21. USDA. Phase II - Scrapie: Ovine Slaughter Surveillance Study 2002-2003. Fort Collins, Colo: USDA:APHIS:VS, CEAH, National Health Monitoring System, 2003;No. N419.0104. Ref Type: Generic.
22. DeSilva U, Guo X, Kupfer DM, et al. Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep. Cytogenet Genome Res 2003;102:89-94.
23. Elsen JM, Amigues Y, Schelcher F, et al. Genetic susceptibility and transmission factors in scrapie: detailed analysis of an epidemic in a closed flock of Romanov. Arch Virol 1999;144:431-445.