Comparative study of three intramuscular anaesthetic combinations (medetomidine/ketamine, medetomidine/ fentanyl/midazolam and xylazine/ketamine) in rabbits

Veterinary Anaesthesia and Analgesia

Volumn 32, Issue 5, 2005, Pages 261-270

  Henke, Julia ^a,c   Astner, Susanne ^a   Brill, Thomas ^a   Eissner, Barbara ^a   Busch, Raymonde ^b   Erhardt, Wolf ^a  

^a Institute for Experimental Oncology and Therapy Research   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anaesthesia; Fentanyl; Intramuscular; Ketamine; Medetomidine; Midazolam; Rabbit; Xylazine; 2 agonist drugs

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANESTHETIC AGENT; FENTANYL; KETAMINE; MEDETOMIDINE; XYLAZINE;

ANESTHESIA; ANIMAL; ANIMAL DISEASE; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; EXPERIMENTAL ANIMAL; FEMALE; HEMODYNAMICS; INTRAMUSCULAR DRUG ADMINISTRATION; PHYSIOLOGY; PROSPECTIVE STUDY; RABBIT; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ANESTHESIA; ANESTHETICS, COMBINED; ANIMALS; ANIMALS, LABORATORY; CROSS-OVER STUDIES; FEMALE; FENTANYL; HEMODYNAMIC PROCESSES; INJECTIONS, INTRAMUSCULAR; KETAMINE; MEDETOMIDINE; PROSPECTIVE STUDIES; RABBITS; TREATMENT OUTCOME; XYLAZINE;

EID: 26944445089     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2005.00242.x     Document Type: Article

References (30)

1. Avsaroglu H, Versluis A, Hellebrekers LJ et al. (2003) Strain differences in response to propofol, ketamine and medetomidine in rabbits. Vet Rec 152, 300.
2. Brown JH, Pleuvry BJ, Kay B (1980) Respiratory effects of a new opiate analgesic, R 39209, in the rabbit: comparison with fentanyl. Br J Anaesth 52, 1101-1106.
3. Difilippo SM, Norberg PJ, Suson UD et al. (2004) A comparison of xylazine and medetomidine in an anaesthetic combination in New Zealand White rabbits. Contemp Top Lab Anim Sci 43, 32-34.
4. Dupras J, Vachon P, Cuvelliez S et al. (2001) Anesthesia of the New Zealand rabbit using the combination of tiletamine-zolazepam and ketamine-midazolam with and without xylazine. Can Vet J 42, 455-460.
5. Erhardt W (1984) Anästhesieverfahren beim Kaninchen. Tierärztl Prax 12, 391-402.
6. Erhardt W, Stephan M, Schatzmann U et al. (1986/87) Immediate and complete reversal of anaesthesia by simultaneous administered benzodiazepine antagonists and opioid antagonists in the dog. J Vet Anaesth 14, 90-99.
7. Fehr M (1984) Narkose bei Heimtieren. Kleintierprax 29, 313-318.
8. Flecknell PA, John M, Mitchell M et al. (1983) Neuroleptanalgesia in the rabbit. Lab Anim 17, 104-109.
9. Haberstroh J, Henke J (2004) Kaninchen. In: Anästhesie und Analgesie beim Klein- und Heimtier (1st edn). Erhardt W, Henke J, Haberstroh J (eds). Schattauer, Stuttgart, Germany, pp. 629-641.
10. Hall LW, Clarke KW, Trim CM (2001) Veterinary Anaesthesia (10th edn). WB Saunders, London, UK.
11. Harabacz I (1981) Die Neuroleptanalgesie mit Ketamin-Xylazin beim Kaninchen. Vet Med thesis, LMU Munich.
12. Hedenqvist P (2001) Assessment of ketamine/medetomidine anaesthesia in the New Zealand White rabbit. Vet Anaesth Analg 28, 18-25.
13. Hedenqvist P, Orr HE, Roughan HE et al. (2002) Anaesthesia with ketamine/medetomidine in the rabbit: influence of route of administration and the effect of combination with Butorphanol. Vet Anaesth Analg 29, 14-19.
14. Hellebrekers LJ, de Boer EJW, van Zuylen MA et al. (1997) A comparison between medetomidine-ketamine and medetomidine-propofol anaesthesia in rabbits. Lab Anim 31, 58-69.
15. Henke J, Roberts U, Otto K et al. (1993) Fully antagonizable anaesthesia of the guinea pig. Part II: Clinical investigations. In: Neue Aspekte der Veterinäranästhesie und Intensivtherapie (1st edn). Schmidt-Oechtering G, Alef M (eds). Paul Parey, Berlin, Germany, p. 296.
16. Henke J, Brill T, Haberstroh J et al. (1995) General anaesthesia in several mammal species. Tierschutzbeauft 2, 171-187.
17. Henke J, Roberts U, Otto K et al. (1996) Klinische Untersuchungen zur i.m. Kombinationsanästhesie mit Fentanyl/Climazolam/Xylazin und postoperativer i.v. Antagonisierung mit Naloxon/Sarmazenil/Yohimbin beim Meerschweinchen. Tierärztl Prax 24, 85-87.
18. Henke J, Lendl C, Mantel R et al. (1998) Reversal of anaesthesia in rats: effects on various variables. Proceedings of the Spring meeting AVA, Edinburgh, p. 70.
19. Henke J, Schneider E, Erhardt W (2000) Medetomidine combination anaesthesia with and without antagonisation- influence on vital variables in mongolian gerbils (mesocricetus unguiculatus). Proceedings of the 7th WCVA, Berne, Switzerland, pp. 99-100.
20. Lipman NS, Marini RP, Erdman SE (1990) A comparison of ketamine/xylazine and ketamine/xylazine/acepromazine anesthesia in the rabbit. Lab Anim Sci 40, 395-398.
21. Marcus R, Peritz E, Gabriel KR (1976) On closed testing procedures with special reference to ordered analysis of variance. Biometrika 63, 655-660.
22. Marini RP, Avison DL, Corning BF et al. (1992) Ketamine/ xylazine/butorphanol: a new anesthetic combination for rabbits. Lab Anim Sci 42, 57-62.
23. Mero MS, Vainionpää S, Vasenius J et al. (1989) Medetomidine-ketamine-diazepam anaesthesia in the rabbit. Acta Vet Scand 85(Suppl.), 135-137.
24. Peeters ME, Gil D, Teske E et al. (1988) Four methods for general anaesthesia in the rabbit: a comparative study. Lab Anim 22, 355-360.
25. Popilskis SJ, Oz MC, Gorman P et al. (1991) Comparison of xylazine with tiletamine-zolazepam (Telazol) and xylazine-ketamine anesthesia in rabbits. Lab Anim Sci 41, 51-53.
26. Roberts U, Henke J, Brill T et al. (1993) Fully antagonizable anaesthesia of the guinea pig. Part I: Experimental investigations. In: Neue Aspekte der Veterinäranästhesie und Intensivtherapie (1st edn). Schmidt-Oechtering G, Alef M (eds). Paul Parey, Berlin, p. 295.
27. Sanford TD, Colby ED (1980) Effect of xylazine and ketamine on blood pressure, heart rate and respiratory rate in rabbits. Lab Anim Sci 30, 519-523.
28. Scabell P, Henke J, Deppe H et al. (1999) Vergleichsuntersuchungen zur Medetomidin-Kombinationsanästhesie beim Hund. Tierärztl Prax 27, 231-238.
29. Sedgwick CJ (1986) Anesthesia for rabbits. Vet Clin North Am Food Anim Pract 2, 731-736.
30. Verstegen J, Fargetton X, Donnay I et al. (1991) An evaluation of medetomidine/ketamine and other drug combinations for anaesthesia in cats. Vet Rec 128, 32-35.