Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 9, 2005, Pages 777-788

  Winkel, Kenneth D ^a   Tibballs, James ^a,b   Molenaar, Peter ^d   Lambert, Gavin ^c   Coles, Peter ^a   Ross Smith, Mark ^a   Wiltshire, Carolyn ^a   Fenner, Peter J ^e   Gershwin, Lisa Ann ^f   Hawdon, Gabrielle M ^a   Wright, Christine E ^a   Angus, James A ^a,g  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Royal Children's Hospital   (Canada)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e Surf Life Saving Australia   (Australia)

^f JAMES COOK UNIVERSITY   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Carukia barnesi; Catecholamines; Irukandji syndrome; Jellyfish; Neuronal sodium channel; Noradrenaline; Sympathetic nervous system; Venom

Indexed keywords

ATROPINE; NORADRENALIN; OMEGA CONOTOXIN GVIA; PRAZOSIN; PROPRANOLOL; TETRODOTOXIN; VENOM; CHOLINERGIC RECEPTOR BLOCKING AGENT; COELENTERATE VENOM; VENOM ANTISERUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CARDIOVASCULAR EFFECT; CARUKIA BARNESI; CONTROLLED STUDY; GUINEA PIG; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INOTROPISM; JELLYFISH; NONHUMAN; RAT; STATISTICAL ANALYSIS; SWINE; SYMPATHETIC TONE; TACHYCARDIA; VASOCONSTRICTION; ANIMAL; CARDIOVASCULAR SYSTEM; CUBOZOA; DOSE RESPONSE; DRUG EFFECT; HEART ATRIUM; HEART CONTRACTION; PHYSIOLOGY;

ANIMALS; ANTIVENINS; ATROPINE; CARDIOVASCULAR SYSTEM; CNIDARIAN VENOMS; CUBOZOA; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART ATRIA; HUMANS; MYOCARDIAL CONTRACTION; PARASYMPATHOLYTICS; PROPRANOLOL; RATS; SWINE;

EID: 26944436348     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2005.04258.x     Document Type: Article

References (62)

1. Burnett JW, Currie B, Fenner P, Rifkin J, Williamson J. Cubozoans ('Box jellyfish'). In: Williamson J, Fenner P, Burnett JW, Rifkin J (eds). Venomous and Poisonous Marine Animals. University of New South Wales Press, Sydney. 1996; 236-83.
2. Flecker H. Irukandji sting to North Queensland bathers without production of weals but with severe general symptoms. Med. J. Aust. 1952; 2: 89-91.
3. Barnes JH. Cause and effect in Irukandji stingings. Med. J. Aust. 1964; 14: 897-904.
4. Grady JD, Burnett JW. Irukandji-like syndrome in South Florida divers. Ann. Emerg. Med. 2003; 42: 763-6.
5. Cheng AC, Winkel KD, Hawdon GM, McDonald M. Irukandji-like syndrome in Victoria. Aust. N.Z. J. Med. 1999; 29: 835.
6. Yoshimoto CM, Yanagihara AA. Cnidarian (coelenterate) envenomations in Hawai'i improve following heat application. Trans. R. Soc. Trop. Med. Hyg. 2002; 96: 300-3.
7. Fenner PJ, Williamson JA, Burnett JW et al. The 'Irukandji syndrome' and acute pulmonary oedema. Med. J. Aust. 1988; 149: 150-6.
8. Fenner P, Carney I. The Irukandji syndrome. A devastating syndrome caused by a north Australian jellyfish. Aust. Fam. Physician 1999; 28: 1131-7.
9. Mulcahy R, Little M. Thirty cases of Irukandji envenomation from far north Queensland. Emerg. Med. 1997; 9: 297-9.
10. Huynh TT, Seymour J, Pereira P et al. Severity of Irukandji syndrome and nematocyst identification from skin scrapings. Med. J. Aust. 2003; 178:38-41.
11. Fenner PJ, Hadok JC. Fatal envenomation by jellyfish causing Irukandji syndrome. Med. J. Aust. 2002; 177: 362-3.
12. Fenner PJ, Heazlewood RJ. Papilloedema and coma in a child. Undescribed symptoms of the 'Irukandji' syndrome. Med. J. Aust. 1997; 167: 650.
13. Southcott RV. Studies on Australian cubomedusae including a new genus and species apparently harmful to man. Aust. J. Mar. Fresh. Res. 1956; 7: 254-80.
14. Kinsey B, ed. More Barnes on Box Jellyfish. Sir George Fisher Centre for Tropical Marine Studies, James Cook University of North Queensland, Townsville, 1988.
15. Little M, Mulcahy RF, Wenck DJ. Life-threatening cardiac failure in a healthy young female with Irukandji syndrome. Anaesth. Intensive Care 2001; 29: 178-80.
16. Southcott RV. Revision of some Carybdeidae (Schyphozoa cubomedusae), including a description of the jellyfish responsible for the 'Irukandji syndrome'. Aust. J. Zool. 1967; 15: 651-71.
17. Fenner PJ, Williamson J, Callanan VI, Audley I. Further understanding of, and a new treatment for, 'Irukandji' (Carukia barnesi) stings. Med. J. Aust. 1986; 145: 569-74.
18. Wiltshire CJ, Sutherland SK, Fenner PJ, Young AR. Optimization and preliminary characterization of venom isolated from 3 medically important jellyfish. The box (Chironex fleckeri), Irukandji (Carukia barnesi), and blubber (Catostylus mosaicus) jellyfish. Wildern. Environ. Med. 2000; 11: 241-50.
19. Winkel KD, Christopoulos A, Coles P et al. Irukandji (Carukia barnesi) venom contains a potent neuronal sodium channel agonist. In: Proceedings of the XIIIth Congress of the International Society on Toxinology Proceedings Paris, France. 2000; 83 (Abstract).
20. Winkel KD, Tibballs J, Hawdon GM et al. The in vivo analysis of 'Irukandji' (Carukia barnesi) and 'Jimble' (Carybdea rastoni) jellyfish venom. In: Proceedings of the Australian Health and Medical Research Congress. 2002; 2010 (Abstract).
21. Tibballs J, Hawdon GM, Winkel KD et al. The in vivo cardiovascular effects of Irukandji (Carukia barnesi) venom. In: Proceedings of the XIIIth Congress of the International Society on Toxinology Proceedings Paris, France. 2000; 276 (Abstract).
22. Angus JA, Ross-Smith M, Coles P et al. In vitro analysis of 'Irukandji' (Carukia barnesi) and 'Jimble' jellyfish (Carybdea rastoni) venom. In: Proceedings of the Australian Health and Medical Research Congress. 2002; 1231 (Abstract).
23. Angus JA, Broughton A, Mulvany MJ. Role of α-adrenoceptors in constrictor responses of rat, guinea-pig and rabbit small arteries to neural activation. J. Physiol. 1988; 403: 495-510.
24. Lew MJ, Flanders S. Mechanisms of melatonin-induced vasoconstriction in the rat tail artery: A paradigm of weak vasoconstriction. Br. J. Pharmacol. 1999; 126: 1408-18.
25. Sarsero D, Fujiwara T, Molenaar P, Angus JA. Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists. Br. J. Pharmacol. 1998; 125: 109-19.
26. 1-adrenoceptor in human atrium and recombinant receptors. Naunyn Schmiedebergs Arch. Pharmacol. 2003; 368: 496-503.
27. Sarsero D, Russell FD, Lynham JA et al. (-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the β1-adrenoceptor. Naunyn Schmiedebergs Arch. Pharmacol. 2003; 367: 10-21.
28. Medvedev OS, Esler MD, Angus JA, Cox HS, Eisenhofer G. Simultaneous determination of plasma noradrenaline and adrenaline kinetics. Responses to nitroprusside-induced hypotension and 2-deoxyglucose-induced glucopenia in the rabbit. Naunyn Schmiedebergs Arch. Pharmacol. 1990; 341: 192-9.
29. Ludbrook J. Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc. Res. 1994; 28: 303-11.
30. Freire-Maia L, Campos JA. Response to the letter to the editor by Gueron and Ovsyshcher on the treatment of the cardiovascular manifestations of scorpion envenomation. Toxicon 1987; 25: 125-30.
31. Sutherland SK, Tibballs J. Other jellyfish of importance. In: Sutherland SK, Tibballs J (eds). Australian Animal Toxins: The Creatures, Their Venom and Care of the Envenomed Patient. Oxford University Press, Melbourne. 2001; 592-623.
32. Nicholson GM, Graudins A. Spiders of medical importance in the Asia-Pacific: Atracotoxin, latrotoxin and related spider neurotoxins. Clin. Exp. Pharmacol. Physiol. 2002; 29: 785-94.
33. Winkel KD, Hawdon GM, Fenner P, Gershwin LA, Collins AG, Tibballs J. Jellyfish antivenoms: Past, present and future. J. Toxicol. Toxin Rev. 2003; 22: 115-28.
34. Ramasamy S, Isbister GK, Seymour JE, Hodgson WC. The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: Efficacy of pre-treatment with antivenom, verapamil and magnesium sulphate. Toxicon 2004; 43: 685-90.
35. Dawson AH. Fatal envenomation by jellyfish causing Irukandji syndrome. Med. J. Aust. 2003; 178: 139.
36. Albertson TE, Dawson A, de Latorre F et al. TOX-ACLS: Toxicologic-oriented advanced cardiac life support. Ann. Emerg. Med. 2001; 37 (Suppl.): S78-90.
37. Corkeron MA. Magnesium infusion to treat Irukandji syndrome. Med. J. Aust. 2003; 178: 411.
38. Fawcett WJ, Haxby EJ, Male DA. Magnesium: Physiology and pharmacology. Br. J. Anaesth. 1999; 83: 302-20.
39. Ohtsuka S, Oyake Y, Seo Y, Eda K, Yamaguchi I. Magnesium sulphate infusion suppresses the cardiac release of noradrenaline during a handgrip stress test. Can. J. Cardiol. 2002; 18: 133-40.
40. Corkeron M, Pereira P, Makrocanis C. Early experience with magnesium administration in Irukandji syndrome. Anaesth. Intensive Care 2004; 32: 666-9.
41. Altman D, Carroli G, Duley L et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie trial: A randomised placebo-controlled trial. Lancet 2002; 359: 1877-90.
42. Fenner PJ, Harrison SL. Irukandji and Chironex fleckeri jellyfish envenomation in tropical Australia. Wildern. Environ. Med. 2000; 11: 233-40.
43. Endean R, Noble M. Toxic material from the tentacles of the cubomedusan Chironex fleckeri. Toxicon 1971; 9: 255-64.
44. Calton GJ, Burnett JW. Partial purification of Chironex fleckeri (sea wasp) venom by immunochromatography with antivenom. Toxicon 1986; 24: 416-20.
45. Currie B. Clinical implications of research on the box-jellyfish Chironex fleckeri. Toxicon 1994; 32: 1305-13.
46. Barnes JH. Extraction of cnidarian venom from living tentacle. In: Russell FE, Saunders PR (eds). Animal Toxins. Pergamon Press, Oxford. 1967; 115-29.
47. Olson CE, Pockl EE, Calton GJ, Burnett JW. Immunochromatographic purification of a nematocyst toxin from the cnidarian Chironex fleckeri (sea wasp). Toxicon 1984; 22: 733-42.
48. Koyama T, Noguchi K, Matsuzaki T, Sakanashi M, Nakasone J, Miyagi K. Haemodynamic effects of the crude venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rabbits. Toxicon 2003; 41: 621-31.
49. Endean R, Duchemin C, McColm D, Fraser EH. A study of the biological activity of toxic material derived from nematocysts of the cubomedusan Chironex fleckeri. Toxicon 1969; 6: 179-204.
50. Bloom DA, Burnett JW, Alderslade P. Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside. Toxicon 1998; 36: 1075-85.
51. Carrette T, Seymour J. A rapid and repeatable method for venom extraction from cubozoan nematocysts. Toxicon 2004; 44: 135-9.
52. Burnett JW, Calton GJ. The case for verapamil use in alarming jellyfish stings remains. Toxicon 2004; 44: 817-18.
53. Mazzei de Dàvila CA, Dàvila DF, Donis JH, de Bellabarba GA, Villarreal V, Barboza JS. Sympathetic nervous system activation, antivenin administration and cardiovascular manifestations of scorpion envenomation. Toxicon 2002; 40: 1339-46.
54. Ramasamy S, Isbister GK, Seymour JE, Hodgson WC. The in vivo cardiovascular effects of the Irukandji jellyfish (Carukia barnesi) nematocyst venom and a tentacle extract in rats. Toxicol. Lett. 2005; 155: 135-41.
55. Gordon D, Martin-Eauclaire MF, Cestele S et al. Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels. J. Biol. Chem. 1996; 271: 8034-45.
56. Bailey PM, Little M, Jelinek GA, Wilce JA. Jellyfish envenoming syndromes: Unknown toxic mechanisms and unproven therapies. Med. J. Aust. 2003; 178: 34-7.
57. Cupo P, Jurca M, Azeedo-Marques MM, Oliveira JS, Hering SE. Severe scorpion envenomation in Brazil. Clinical, laboratory and anatomopathological aspects. Rev. Inst. Med. Trop. São Paulo 1994; 36: 67-76.
58. Daisley H, Alexander D, Pitt-Miller P. Acute myocarditis following Tityus trinitatis envenoming: Morphological and pathophysiological characteristics. Toxicon 1999; 37: 159-65.
59. 1-adrenergic receptor transgenic mice. Proc. Natl Acad. Sci. USA 1999; 96: 7059-64.
60. Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of β-adrenergic signaling in heart failure? Circ. Res. 2003; 93: 896-906.
61. Duncan AW, Tibballs J, Sutherland SK. Effects of Sydney funnel-web spider envenomation in monkeys, and their clinical implications. Med. J. Aust. 1980; 2: 429-35.
62. Mylecharane EJ, Spence I, Sheumack DD, Claassens R, Howden ME. Actions of robustoxin, a neurotoxic polypeptide from the venom of the male funnel-web spider (Atrax robustus), in anaesthetized monkeys. Toxicon 1989; 27: 481-92.