Medicine: Coincident scrapie infection and nephritis lead to urinary prion excretion

Science

Volumn 310, Issue 5746, 2005, Pages 324-326

  Seeger, Harald ^a   Heikenwalder, Mathias ^a   Zeller, Nicolas ^a   Kranich, Jan ^a   Schwarz, Petra ^a   Gaspert, Ariana ^b   Seifert, Burkhardt ^c   Miele, Gino ^a   Aguzzi, Adriano ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; PROTEINS;

INOCULATION; KIDNEY DISORDERS; LYMPHATIC SYSTEMS; SCRAPIE INFECTION;

DISEASES;

PRION PROTEIN;

MEDICINE;

ARTICLE; CENTRAL NERVOUS SYSTEM; CHRONIC INFLAMMATION; GENE OVEREXPRESSION; INFLAMMATION; KIDNEY DISEASE; LYMPHATIC SYSTEM; LYMPHOCYTE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; SCRAPIE; URINARY EXCRETION; VIRUS INFECTIVITY; WILD TYPE; ANIMAL; BRAIN; C57BL MOUSE; DISEASE TRANSMISSION; METABOLISM; MOUSE; NEW ZEALAND BLACK MOUSE; PATHOLOGY; URINE;

ANIMALS; BRAIN; MICE; MICE, INBRED C57BL; MICE, INBRED NZB; NEPHRITIS; PRPSC PROTEINS; SCRAPIE;

EID: 26844563437     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1118829     Document Type: Article

References (20)

1. H. Fraser, A. G. Dickinson, Nature 226, 462 (1970).
2. J. Castilla, P. Saa, C. Hetz, C. Soto, Cell 121, 195 (2005).
3. S. B. Prusiner, Science 216, 136 (1982).
4. H. Büeler et al., Cell 73, 1339 (1993).
5. A. Aguzzi, M. Heikenwalder, Immunity 22, 145 (2005).
6. M. Heikenwalder et al., Science 307, 1107 (2005).
7. S. R. Jones, Am. J. Med. 88, S30 (1990).
8. Materials and methods are available as supporting material on Science Online.
9. P. C. Klohn, L. Stoltze, E. Flechsig, M. Enari, C. Weissmann, Proc. Natl. Acad. Sci. U.S.A. 100, 11666 (2003).
10. M. Fischer et al., EMBO J. 15, 1255 (1996).
11. G. M. Shaked et al., J. Biol. Chem. 276, 31479 (2001).
12. M. W. Head, E. Kouverianou, L. Taylor, A. Green, R. Knight, Neurology 64, 1794 (2005).
13. A. Serban, G. Legname, K. Hansen, N. Kovaleva, S. B. Prusiner, J. Biol. Chem. 279, 48817 (2004).
14. H. Furukawa et al., J. Biol. Chem. 279, 23661 (2004).
15. C. A. Llewelyn et al., Lancet 363, 417 (2004).
16. F. Houston, J. D. Foster, A. Chong, N. Hunter, C. J. Bostock, Lancet 356, 999 (2000).
17. Y. Shibayama et al., Acta Pathol. Jpn. 32, 695 (1982).
18. J. Tateishi, Y. Sato, M. Koga, H. Doi, M. Ohta, Acta Neuropathol. (Berlin) 51, 127 (1980).
19. D. C. Gajdusek, C. J. Gibbs Jr., M. Alpers, Science 155, 212 (1967).
20. -/- mice. Supported by grants from the Bundesamt für Bildung und Wissenschaft, the Swiss National Foundation, and the National Center of Competence in Research on neural plasticity and repair (to A.A.). M.H. is supported by a Career Development Award of the university of Zürich.