Modulation of the development of humoral immunity by topically applied acetone, ethanol, and 12-O-tetradecanoylphorbol-13-acetate

Fundamental and Applied Toxicology

Volumn 33, Issue 1, 1996, Pages 129-139

  Singh, Kameshwar P ^a   Yoon, Hyunah L ^a   Ratner, Stuart ^b   Reiners Jr , John J ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b Cancer Biology Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ALCOHOL; CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DOSE RESPONSE; HUMORAL IMMUNITY; MOUSE; NONHUMAN; SPLEEN CELL; T LYMPHOCYTE; TOPICAL DRUG ADMINISTRATION;

ANIMALIA; OVIS ARIES;

EID: 26844545160     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0150     Document Type: Article

References (64)

1. + T cell subsets. Immunol. Rev. 123, 5-22.
2. Akhurst, R. J., Fee, F., and Balmain, A. (1988). Localized production of TGF-β in tumour promoter-stimulated mouse epidermis. Nature 331, 363-365.
3. Bagasra, O., Howeedy, A., Dorio, R., and Kajdacsy-Balla, A. (1987). Functional analysis of T cell subsets in chronic experimental alcoholism. Immunology 61, 63-69.
4. Bagasra, O., Howeedy, A., and Kajdacsy-Balla, A. (1988). Macrophage function in chronic experimental alcoholism. I. Modulation of surface receptors and phagocytosis. Immunology 65, 405-409.
5. Baxter, C. S., Andringa, A., Chalfin, K., and Miller, M. L. (1989). Comparative histomorphometric changes in SENCAR mouse epidermis in response to multiple treatments with complete and stage-specific tumor promoting agents. Carcinogenesis 10, 1855-1861.
6. 2 inhibits production of Th1 lymphokines but not Th2 lymphokines. J. Immunol. 146, 108-113.
7. Berry, D. L., Bracker, W. M., Fischer, S. M., Viaje, A., and Slaga, T. J. (1978). Metabolic conversion of 12-O-tetradecanoylphorbol-13-acetate in adult and newborn mouse skin and mouse liver microsomes. Cancer Res. 38, 2301-2306.
8. Castagna, M., Yagello, M., Rabourdin-Combe, C., and Fridman, W. H. (1980). Tumor-promoting phorbol diesters inhibit in vitro antibody synthesis. Cancer Lett. 8, 365-371.
9. Chang, M.-P., and Norman, D. C. (1991). Immunotoxicity of alcohol in young and old mice. II. Impaired T cell proliferation and T cell-dependent antibody responses of young and old mice fed ethanol-containing liquid diet. Mech. Ageing Dev. 57, 175-186.
10. Chang, M.-P., and Norman, D. C. (1992). Mechanism of ethanol-mediated immunosuppression in mice: Ethanol suppresses T-cell proliferation without affecting IL2 production and IL2 receptor expression. Int. J. Immunopharmacol. 14, 707-719.
11. Cunningham, A. J., and Szenberg, A. (1968). Further improvement in the plaque technique for detecting single antibody-forming cells. Immunology 14, 599-600.
12. DiGiovanni, J., Walker, S. C., Beltran, L., Naito, M., and Eastin, W. C., Jr. (1991). Evidence for a common genetic pathway controlling susceptibility to mouse skin tumor promotion by diverse classes of promoting agents. Cancer Res. 51, 1398-1405.
13. Domiati-Saad, R., and Jerrells, T. R. (1993). The influence of age on blood alcohol levels and ethanol-associated immunosuppression in a murine model of ethanol consumption. Alcohol. Clin. Exp. Res. 17, 382-388.
14. Dorio, R. J. (1990). The effect of ethanol on signal transduction in the rat alveolar macrophage. In Alcohol, Immunomodulation, and AIDS (D. Seminara, R. R. Watson, and A. Pavlowski, Eds.), pp. 135-143. A. R. Liss, New York.
15. Eastin, W. C., Jr. (1989). Developing standards for dermal initiation/promotion screening studies. In Progress in Clinical and Biological Research (T. J. Slaga, A. J. P. Klein-Szanto, R. K. Boutwell, D. E. Stevenson, H. L. Spitzer, and B. D'Motto, Eds.), pp. 295-312. A. R. Liss, New York.
16. Fidler, J. M. (1975). In vivo immune response to TNP hapten coupled to thymus-independent carrier lipopolysaccharide. Cell. Immunol. 16, 223-236.
17. Fischer, S. M., Furstenberger, G., Marks, F., and Slaga, T. J. (1987). Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: A comparison between SENCAR and NMRI mice. Cancer Res. 47, 3174-3179.
18. Fischer, S. M., O'Connell, F. J., Conti, C. J., Tacker, K. C., Fries, J. W., Patrick, K. E., Adams, L. M., and Slaga, T. J. (1987). Characterization of an inbred strain of the SENCAR mouse that is highly sensitive to phorbol esters. Carcinogenesis 8, 421-424.
19. Giminez-Conti, I. B., Bianchi, A. B., Fischer, S. M., Reiners, J. J., Jr., Conti, C. J., and Slaga, T. J. (1992). Dissociation of sensitivities to tumor promotion and progression in outbred and inbred SENCAR mice. Cancer Res. 52, 3432-3235.
20. Halliday, G. M., Odling, K. A., Ruby, J. C., and Muller, H. K. (1988). Suppressor cell activation and enhanced skin allograft survival after tumor promoter but not initiator induced depletion of cutaneous Langerhans cells. J. Invest. Dermatol. 90, 293-297.
21. Hodgkin, P. D., Castle, B. E., and Kehry, M. R. (1994). B cell differentiation induced by helper T cell membranes: Evidence for sequential isotype switching and a requirement for lymphocytes during proliferation. Eur. J. Immunol. 24, 239-246.
22. Holsapple, M. P., Eads, M., Stevens, W. D., Wood, S. C., Kaminski, N. E., Morris, D. L., Poklis, A., Kaminski, E. J., and Jordan, S. D. (1993). Immunosuppression in adult female B6C3F1 mice by chronic exposure to ethanol in a liquid diet. Immunopharmacology 26, 31-51.
23. Iversen, O. H., Paulsen, J. E., and Schjolberg, A. (1981). The time needed for normalization of hairless mouse epidermis after treatment with twice weekly topical skin applications of 10 nmol 12-O-tetradecanoylphorbol-13-acetate in acetone, or acetone alone, for 18 weeks. A morphologic and cell kinetic study. Carcinogenesis 2, 1353-1358.
24. Jerrells, T. R., Marietta, C. A., Eckardt, M. J., Majchrowicz, E., and Weight, F. F. (1986). Effects of ethanol administration on parameters of immunocompetency in rats. J. Leukocyte Biol. 39, 499-510.
25. Jerrells, T. R., Smith, W., and Eckardt, M. J. (1990). Murine model of ethanol-induced immunosuppression. Alcohol. Clin. Exp. Res. 14, 546-550.
26. Kadner, S. S., Katz, J., Levitz, M., and Finlay, T. H. (1985). The 65-kDa phorbol-diester hydrolase in mouse plasma is esterase 1 and is immunologically distinct from the 56-kDa phorbol diester hydrolase in mouse skin. J. Biol. Chem. 260, 15604-15609.
27. Kodari, E., Pavone, A., and Reiners, J. J., Jr. (1991). Local- and systemic-mediated suppression of contact hypersensitivity in mice by several structurally unrelated classes of tumor promoters. Carcinogenesis 12, 1933-1937.
28. Koller, L. D., and Kovacic, S. (1974). Decreased antibody formation in mice exposed to lead. Nature 250, 148-150.
29. Koller, L. D., Exon, J. H., and Roan, J. G. (1976). Humoral antibody response in mice after single dose exposure to lead or cadmium. Proc. Soc. Exp. Biol. Med. 151, 339-342.
30. Kuratsune, M., Kohchi, S., Horie, A., and Nishizumi, M. (1971). Test of alcoholic beverages and ethanol solutions for carcinogenicity and tumor-promoting activity. Gann 62, 395-405.
31. Lee, W. Y., Fischer, S. M., Butler, A. P., and Locniskar, M. F. (1993). Modulation of interleukin-1 mRNA expression in mouse epidermis by tumor promoters and antagonists. Mol. Carcinogenesis 7, 26-35.
32. Lewis, J. G., and Adams, D. O. (1986). Enhanced release of hydrogen peroxide and metabolites of arachidonic acid by macrophages from SENCAR mice following stimulation with phorbol esters. Cancer Res. 46, 5696-5700.
33. Lopez, M. C., Huang, D. S., Borgs, P., Wang, Y., and Watson, R. R. (1994). Modification of lymphocyte subset in the intestinal-associated immune system and thymus by chronic ethanol consumption. Alcohol. Clin. Exp. Res. 18, 8-11.
34. Manetti, R., Barak, V., Piccinni, M.-P., Sampognaro, S., Parronchi, P., Maggi, E., Dinarello, C. A., and Romagnani, S. (1994). Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones. Res. Immunol. 145, 93-100.
35. Mastro, A. M., Krupta, T. A., and Smith, P. A. (1979). Interaction of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate with cells in the mixed-lymphocyte culture. Cancer Res. 39, 4078-4082.
36. Mastro, A. M., and Mueller, G. C. (1978). Inhibition of the mixed lymphocyte proliferative response by phorbol esters. Biochim. Biophys. Acta 517, 246-254.
37. Mastro, A. M., and Pepin, K. G. (1980). Suppression of lectin-stimulated DNA synthesis in bovine lymphocytes by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 40, 3307-3312.
38. Müller-Decker, K., Furstenberger, G., and Marks, F. (1994). Keratinocyte-derived proinflammatory key mediators and cell viability as in vitro parameters of irritancy: A possible alternative to the Draize skin irritation test. Toxicol. Appl. Pharmacol. 127, 99-108.
39. Reiners, J. J., Jr., Yoon, H. L., and Singh, K. P. (1995). Roles of immunosurveillance and immunostimulation in the process of chemical carcinogenesis in murine skin. In Skin Cancer: Mechanisms and Human Relevance (H. Mukhtar, Ed.), pp. 237-254. CRC Press, Boca Raton, FL.
40. Rittenberg, M. B., and Pratt, K. L. (1969). Antitrinitrophenyl (TNP) plaque assay: Primary response of Balb/c mice to soluble and particulate immunogen. Proc. Soc. Exp. Biol. Med. 132, 575-581.
41. Robertson, F. M., Bijur, G. N., Oberyszyn, A. S., Nill, M. R., Boros, L. G., Spencer, W. J., Sabourin, C. L. K., and Oberyszyn, T. M. (1995). Interleukin-1α in murine multistage skin carcinogenesis. In Skin Cancer: Mechanisms and Human Relevance (H. Mukhtar, Ed.), pp. 255-272. CRC Press, Boca Raton, FL.
42. Robertson, F. M., Bijur, G. N., Oberyszyn, A. S., Pellegrini, A. E., Boros, L. G., Sabourin, C. L. K., and Oberyszyn, T. M. (1994). Granulocytemacrophage colony stimulating factor gene expression and function during tumor promotion. Carcinogenesis 15, 1017-1029.
43. Roeser, H., Doege, T., and Hecker, E. (1991). Toxicokinetics of tumour promoters of mouse skin. II. Metabolism of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin and biological activities of metabolites. Carcinogenesis 12, 1563-1570.
44. Saad, A. J., and Jerrells, T. R. (1991). Flow cytometric and immunohistochemical evaluation of ethanol-induced changes in splenic and thymic lymphoid cell populations. Alcohol. Clin. Exp. Res. 15, 796-803.
45. Singh, K. P., Saxena, A. K., Kannan, K., Nagale, S. L., Dogra, R. K. S., and Shanker, R. (1982). Immune responses in mice exposed to coal mine dust. Indian J. Exp. Biol. 20, 417-418.
46. Sirak, A. A., Beavis, A. J., and Robertson, F. M. (1991). Enhanced hydroperoxide production by peripheral blood leukocytes following exposure of murine epidermis to 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis 12, 91-95.
47. Sisskin, E. E., and Barrett, J. C. (1981). Hyperplasia of Syrian hamster epidermis induced by single but not multiple treatments with 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 41, 346-350.
48. Sisskin, E. E., Gray, T., and Barrett, J. C. (1982). Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis 3, 403-407.
49. Schoof, R. A., and Baxter, C. S. (1986). Topical application of a tumor promoter induces proliferation of an adherent cell population in murine spleen. Int. J. Immunopharmacol. 8, 455-462.
50. Shopp, G. M., and Munson, A. E. (1984). Suppression of the in vitro specific antibody response by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the mouse. J. Leukocyte Biol. 36, 51-61.
51. Slaga, T. J., Fischer, S. M., Weeks, C. E., and Klein-Szanto, A. J. P. (1981). Cellular and biochemical mechanisms of mouse skin tumor promoters. In Reviews in Biochemical Toxicology (E. Hodgson, J. Bend, and R. M. Philpot, Eds.), Vol. 3, pp. 231-281. Elsevier North-Holland, New York.
52. Slaga, T. J., and Fischer, S. M. (1983). Strain differences and solvent effects in mouse skin carcinogenesis experiments using carcinogens, tumor initiators and promoters. In Progress in Experimental Tumor Research (F. Homburger, Ed.), Vol. 26, pp. 85-109. Karger, Basel.
53. Stenbäck, F. (1969). The tumorigenic effect of ethanol. Acta Pathol. Microbiol. Scand. 77, 325-326.
54. Street, N. E., and Mosmann, T. R. (1991). Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 5, 171-177.
55. Szabo, G., Verma, B., and Catalano, D. (1993). Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: The role of impaired monocyte antigen presentation capacity and mediator production. J. Leukocyte Biol. 54, 534-544.
56. Updyke, L. W., Chuthaputti, A., Pfeifer, R. W., and Yim, G. K. W. (1988). Modulation of natural killer activity by 12-O-tetradecanoylphorbol-13-acetate and benzoyl peroxide in phorbol ester-sensitive (SENCAR) and resistant (B6C3F1) mice. Carcinogenesis 9, 1943-1951.
57. Updyke, L. W., Yoon, H. L., Chuthaputti, A., Pfeifer, R. W., and Yim, G. K. W. (1989). Induction of interleukin-1 and tumor necrosis factor by 12-O-tetradecanoylphorbol-13-acetate in phorbol ester-sensitive (SENCAR) and resistant (B6C3F1) mice. Carcinogenesis 10, 1107-1111.
58. Updyke, L. W., Yoon, H. L., and Pfeifer, R. W. (1991a). Induction of granulocyte-macrophage colony-stimulating activity by 12-O-tetradecanoylphorbol-13-acetate in SENCAR and B6C3F1 mice. Carcinogenesis 12, 735-739.
59. Updyke, L. W., Yoon, H. L., Robinson, J. P., Kiorpes, A. L., Marcus, C. B., and Pfeifer, R. W. (1991b). 3-Methylindole-induced splenotoxicity; functional analysis of immune parameters and lymphocyte phenotyping by flow cytometry. Toxicol. Appl. Pharmacol. 109, 391-398.
60. Wei, H., Tye, L., Bresnick, E., and Birt, D. F. (1990). Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res. 50, 499-502.
61. + lymphocytes. Immunol. Res. 142, 23-28.
62. Zaidi, S. I. A., Singh, K. P., Raisuddin, Saxena, A. K., and Ray, P. K. (1990). Protein A induced abrogation of cyclophosphamide toxicity is associated with concomitant potentiation of immune function of host. Immunopharmacol. Immunotoxicol. 12, 479-512.
63. Zakova, N., Zak, F., Froehlich, E., and Hess, R. (1985). Evaluation of skin carcinogenicity of technical 2,2-bis-(p-glycidyloxyhenyl)propane in CF1 mice. Food Chem. Toxicol. 23, 1081-1089.
64. Zhao, R., and Cao, Y. (1994). Inhibition of systemic delayed type hypersensitivity caused by tumor promoter TPA. J. Shenyang Coll. Pharm. 11, 179-185.