Kinetic and safety studies on intrathecally infused recombinant-methionyl human brain-derived neurotrophic factor in dogs

Fundamental and Applied Toxicology

Volumn 38, Issue 1, 1997, Pages 89-100

  Yaksh, Tony L ^a   Rathbun, Michael L ^a   Dragani, Jean C ^a   Malkmus, Shelle ^a   Bourdeau, Amy R ^b   Richter, Philip ^c   Powell, Harry ^d   Myers, Robert R ^d   LeBel, Carl P ^b  

^a University of California   (United States)

^b AMGEN INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; RECOMBINANT METHIONYL BRAIN DERIVED GROWTH FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COORDINATION; DOG; DRUG CLEARANCE; DRUG SAFETY; HISTOPATHOLOGY; INTRATHECAL DRUG ADMINISTRATION; MALE; MUSCLE TONE; NONHUMAN; PHARMACOKINETICS;

ANIMALIA; CANIS FAMILIARIS;

EID: 26844542977     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1997.2314     Document Type: Article

References (24)

1. Altar, C. A., Criden, M. R., Lindsay, R. M., and DiStefano, P. S. (1993). Characterization and topography of high-affinity 125I-neurotrophin-3 binding to mammalian brain. J. Neurosci. 13, 733-743.
2. Cheng, B., Goodman, Y., Begley, J. G., and Mattson, M. P. (1994). Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury. Brain Res. 650, 331-335.
3. Cheng, B., and Mattson, M. P. (1994). NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res. 640, 56-67.
4. Dittrich, F., Ochs, G., Grosse-Wilde, A., Berweiler, U., Yan, Q., Miller, J. A., Toyka, K. V., and Sendtner, M. (1996). Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons. Exp. Neurol. 141, 225-239.
5. Durant, P. A. C., and Yaksh, T. L. (1986). Distribution in cerebrospinal fluid, blood, and lymph of epidurally injected morphine and insulin in dogs. Anesth. Analg. 65, 583-592.
6. Ernfors, P., Rosario, C. M., Merlio, J. P., Grant, G., Aldskogius, H., and Persson, H. (1993). Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy. Brain Res. Molec. Brain Res. 17, 217-226.
7. Herz, A., and Tescehmacher, H. (1971). Activities and sites of antinociceptive action of morphine-like analgesics and kinetics of redistribution following intravenous, intracerebral and intraventricular application. Adv. Drug Res. 6, 79-119.
8. Koh, J. Y., Gwag, B. J., Lobner, D., and Choi, D. W. (1995). Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 268, 573-575.
9. Koliatsos, V. E., Clatterbuck, R. E., Winslow, J. W., Cayouette, M. H., and Price, D. L. (1993). Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron 10, 359-367.
10. LeBel, C. P., and Foss, J. (1996). Use of a rodent neurotoxicity screening battery in the preclinical safety assessment of recombinant-methionyl human brain-derived neurotrophic factor. Neurotoxicology. 17, 851-864.
11. Lindholm, D., Dechant, G., Heisenberg, C. P., and Thoenen, H. (1993). Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. Eur. J. Neurosci. 5, 1455-1464.
12. Rigler, M. L., Drasner, K., Krejcie, T. C., Yelich, S. J., Scholnick, F. T., DeFontes, J., and Bohner, D. (1991). Cauda equina syndrome after continuous spinal anesthesia. Anesth. Analg. 72, 275-281.
13. Rigler, M. L., and Drasner, K. (1991). Distribution of catheter-injected local anesthetic in a model of the subarachnoid space. Anesthesiology 75, 684-692.
14. Ross, B. K., Coda, B., and Heath, C. H. (1992). Local anesthetic distribution in a spinal model: A possible mechanism of neurologic injury after continuous spinal anesthesia. Reg. Anesth. 17, 69-77.
15. Sabbe, M. B., Grafe, M. R., Mjanger, E., Tiseo, P. J., Hill, H. F., and Yaksh, T. L. (1994). Spinal delivery of sufentanil, alfentanil and morphine in dogs: Physiologic and toxicologic investigations. Anesthesiology 81, 899-920.
16. Sabbe, M. B., Grafe, M. R., Pfeifer, B. L., Mirzai, T. H. M., and Yaksh, T. L. (1993). Toxicology of baclofen continuously infused into the spinal intrathecal space of the dog. Neurotoxicology 14, 397-410.
17. Schnell, L., Schneider, R., Kolbeck, R., Barde, Y. A., and Schwab, M. E. (1994). Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 367, 170-173. [see comments]
18. Siegel, S., and Castellan, N. J. (1988). Non parametric Statistics for the Behavioral Sciences. McGraw-Hill, New York.
19. Siuciak, J. A., Wong, V., Pearsall, D., Wiegand, S. J., and Lindsay, R. M. (1995). BDNF produces analgesia in the formalin test and modifies neuropeptide levels in rat brain and spinal cord areas associated with nociception. Eur. J. Neurosci. 7, 663-670.
20. Vejsada, R., Sagot, Y., and Kato, A. C. (1994). BDNF-mediated rescue of axotomized motor neurones decreases with increasing dose. Neuroreport 5, 1889-1892.
21. Yaksh, T. L. (1981). Spinal opiate analgesia: Characteristics and principles of action. Pain 11, 293-346.
22. Yaksh, T. L., and Malmberg, A. B. (1994). Central pharmacology of nociceptive transmission. In Textbook of Pain (P. Wall and R. Melzack, Eds.), pp. 165-200. 3E, Churchill Livingstone, Edinburgh, UK.
23. Yaksh, T. L., Grafe, M. R., Malkmus, S., Rathbun, M. L., and Eisenach, J. C. (1995). Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs. Anesthesiology 82, 412-427.
24. Yaksh, T. L., Rathbun, M. L., Jage, J., Mirzai, T., Grafe, M., and Hiles, R. A. (1994). Pharmacology and toxicology of chronically infused epidural clonidine HCl in dogs. Fundam. Appl. Toxicol. 23, 319-335.