Structure-activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 23, 2005, Pages 5237-5240

  Pontillo, Joseph ^a   Tran, Joe A ^a   White, Nicole S ^a   Arellano, Melissa ^a   Fleck, Beth A ^a   Marinkovic, Dragan ^a   Tucci, Fabio C ^a   Saunders, John ^a   Foster, Alan C ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Agonist; Cyclohexylpiperazine; Melanocortin 4; Receptor; Synthesis

Indexed keywords

ACETAMIDE DERIVATIVE; LIGAND; MELANOCORTIN 4 RECEPTOR; PIPERAZINE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BENZENEACETAMIDES; HUMANS; LIGANDS; PIPERAZINES; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26844542778     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.061     Document Type: Article

References (13)

1. V. Goodfellow, and J. Saunders Curr. Med. Chem. 3 2003 855
2. T.I. Richardson, P.L. Ornstein, K. Briner, M.J. Fisher, R.T. Backer, C.K. Biggers, M.P. Clay, P.J. Emmerson, L.W. Hertel, H.M. Hsiung, S. Husain, S.D. Kahl, J.A. Lee, T.D. Lindstrom, M.J. Martinelli, J.P. Mayer, J.T. Mullaney, T.P. O'Brien, J.M. Pawlak, K.D. Revell, J. Shah, J.M. Zgombick, R.J. Herr, A. Melekhov, P.B. Sampson, and C.-H.R. King J. Med. Chem. 47 2004 744 and references cited therein
3. B.L. Palucki, M.K. Park, R.P. Nargund, Z. Ye, I.K. Sebat, P.G. Pollard, R.N. Kalyani, R. Tang, T. MacNeil, D.H. Weinberg, A. Vongs, C.I. Rosenblum, G.A. Doss, R.R. Miller, R.A. Stearns, Q. Peng, C. Tamvakopoulos, E. McGowan, W.J. Martin, J.M. Metzger, C.A. Shepherd, A.M. Strack, E. MacIntyre, L.H.T. Van der Ploeg, and A.A. Patchett Bioorg. Med. Chem. Lett. 15 2004 171
4. T.J. Vos, A. Caracoti, J. Che, M. Dai, C.A. Farrer, N.E. Forsyth, S.V. Drabic, R.A. Horlick, D. Lamppu, D.L. Yowe, S. Balani, P. Li, H. Zeng, I.B.J.K. Joseph, L.E. Rodriguez, and C.F. Claiborne J. Med. Chem. 47 2004 1602 and references cited therein
5. I.K. Sebhat, W.J. Martin, Z. Ye, K. Barakat, R.T. Mosley, D.B.R. Johnston, R. Bakshi, B. Palucki, D.H. Weinberg, T. MacNeil, R.N. Kalyani, R. Tang, R.A. Stearns, R.R. Miller, C. Tamvakopoulos, A.M. Strack, E. McGowan, D.E. Cashen, J.E. Drisko, G.J. Hom, A.D. Howard, D.E. MacIntyre, L.H.T. van der Ploeg, A.A. Patchett, and R.P. Nargund J. Med. Chem. 45 2002 4589
6. F. Mutulis, S. Yahorava, I. Mutule, A. Yahorau, E. Liepinsh, S. Kopantshuk, S. Veiksina, K. Tars, S. Belyakov, A. Mishnev, A. Rinken, and J.E.S. Wikberg J. Med. Chem. 47 2004 4613
7. 9
8. J. Pontillo, J.A. Tran, M. Arellano, B.A. Fleck, R. Huntley, D. Marinkovic, M. Lanier, J. Nelson, J. Parker, J. Saunders, F.C. Tucci, W. Jiang, C.W. Chen, N.S. White, A. Foster, and C. Chen Bioorg. Med. Chem. Lett. 14 2004 4417
9. C. Chen, J. Pontillo, B.A. Fleck, Y. Gao, J. Wen, J.A. Tran, F.C. Tucci, D. Marinkovic, A.C. Foster, and J. Saunders J. Med. Chem. 47 2004 6821
10. J.A. Tran, J. Pontillo, M. Arellano, B.A. Fleck, F.C. Tucci, D. Marinkovic, W.C. Chen, J. Saunders, A.C. Foster, and C. Chen Bioorg. Med. Chem. Lett. 15 2005 3434
11. S.A. Nickolls, M.I. Cismowski, X. Wang, M. Wolff, P.J. Conlon, and R.A. Maki J. Pharmacol. Exp. Ther. 304 2003 1217
12. J. Tran, J. Pontillo, M. Arellano, N.S. White, B.A. Fleck, D. Marinkovic, F.C. Tucci, M. Lanier, J. Nelson, J. Saunders, A.C. Foster, and C. Chen Bioorg. Med. Chem. Lett. 15 2005 833
13. A. Wilczynski, X.S. Wang, C.G. Joseph, Z. Xiang, R.M. Bauzo, J.W. Scott, N.B. Sorensen, A.M. Shaw, W.J. Millard, N.G. Richards, and C. Haskell-Luevano J. Med. Chem. 47 2004 2194