Inhibition of aldosterone biosynthesis by staurosporine

Biological Chemistry

Volumn 386, Issue 7, 2005, Pages 663-669

  Bureik, Matthias ^a   Mion, Alexander ^a,c   Kenyon, Christopher J ^b   Bernhardt, Rita ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Adrenodoxin; Aldosterone; Blood pressure; CYP11B2; Cytochrome P450; Protein kinase inhibitor; Staurosporine; Steroid hydroxylation

Indexed keywords

ADRENODOXIN; ALDOSTERONE; ALDOSTERONE SYNTHASE; CYTOCHROME P450; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; PROTEIN KINASE INHIBITOR; STAUROSPORINE; STEROID MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HORMONE INHIBITION; HORMONE SYNTHESIS; HYPOTENSION; IN VIVO STUDY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STEROID HYDROXYLATION;

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANIMALS; COS CELLS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; STAUROSPORINE; STEROID 11-BETA-HYDROXYLASE; STEROID HYDROXYLASES; TRANSFECTION;

BOVINAE;

EID: 26844522046     PISSN: 14316730     EISSN: 14316730     Source Type: Journal    
DOI: 10.1515/BC.2005.077     Document Type: Article

References (41)

1. Abe, K., Yoshida, M., Usui, T., Horinouchi, S., and Beppu, T. (1991). Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases. Exp. Cell Res. 192, 122-127.
2. Bechtel, S., Belkina, N., and Bernhardt, R. (2002). The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme. Eur. J. Biochem. 269, 1118-1127.
3. Bernhardt, R. (1996). Cytochrome P450: structure, function, and generation of reactive oxygen species. Rev. Physiol. Biochem. Pharmacol. 127, 137-221.
4. Bernhardt, R. (2000). The role of adrenodoxin in adrenal steroidogenesis. Curr. Opin. Endocrin. Diab. 7, 109-115.
5. Bilder, G.E., Kasiewski, C.J., and Perrone, M.H. (1990). Phorbol-12, 13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension. J. Pharmacol. Exp. Ther. 252, 526-530.
6. Bruno, S., Ardelt, B., Skierski, J.S., Traganos, F., and Darzynkiewicz, Z. (1992). Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes. Cancer Res. 52, 470-473.
7. Bureik, M., Zeeh, A., and Bernhardt, R. (2002). Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors. Endocr. Res. 28, 351-355.
8. Bureik, M., Zöllner, A., Schuster, N., Montenarh, M., and Bernhardt, T. (2005). Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1). Biochemistry 44, 3821-3830.
9. Cao, P.R. and Bernhardt, R. (1999). Interaction of CYP11B1 (cytochrome P-45011 β) with CYP11A1 (cytochrome P-450scc) in COS-1 cells. Eur. J. Biochem. 262, 720-726.
10. Crissman, H.A., Gadbois, D.M., Tobey, R.A., and Bradbury, E.M. (1991). Transformed mammalian cells are deficient in kinasemediated control of progression through the G1 phase of the cell cycle. Proc. Natl. Acad. Sci. USA 88, 7580-7584.
11. Curnow, K.M., Tusie-Luna, M.T., Pascoe, L., Natarajan, R., Gu, J.L., Nadler, J.L., and White, P.C. (1991). The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol. Endocrinol. 5, 1513-1522.
12. Denner, K. and Bernhardt, R. (1998). Inhibition studies of steroid conversions mediated by human CYP11B1 and CYP11B2 expressed in cell cultures. In: Oxygen Homeostasis and its Dynamics, K. Ishimura, H. Shimada and M. Suematsu, eds. (Tokyo, Japan: Springer Tokyo Inc.), pp. 231-236.
13. Denner, K., Doehmer, J., and Bernhardt, R. (1995). Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 Chinese hamster cells. Endocr. Res. 21, 443-448.
14. Ehmer, P.B., Bureik, M., Bernhardt, R., Muller, U., and Hartmann, R.W. (2002). Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells. J. Steroid Biochem. Mol. Biol. 81, 173-179.
15. Gescher, A. (2000). Staurosporine analogues - pharmacological toys or useful antitumour agents? Crit. Rev. Oncol. Hematol. 34, 127-135.
16. Krohn, A.J., Preis, E., and Prehn, J.H. (1998). Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector. J. Neurosci. 18, 8186-8197.
17. Lever, M.A., Th'ng, J.P., Sun, X., and Hendzel, M.J. (2000). Rapid exchange of histone H1.1 on chromatin in living human cells. Nature 408, 873-876.
18. Lifton, R.P., Dluhy, R.G., Powers, M., Rich, G.M., Cook, S., Ulick, S., and Lalouel, J.M. (1992). A chimeric 11-β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 355, 262-265.
19. MacPhee, I.A., Antoni, F.A., and Mason, D.W. (1989). Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J. Exp. Med. 169, 431-445.
20. Millar, J.A., Leckie, B.J., Morton, J.J., Jordan, J., and Tree, M. (1980). A microassay for active and total renin concentration in human plasma based on antibody trapping. Clin. Chim. Acta 101, 5-15.
21. Monnier, N., Defaye, G., and Chambaz, E.M. (1987). Phosphorylation of bovine adrenodoxin. Structural study and enzymatic activity. Eur. J. Biochem. 169, 147-153.
22. Mornet, E., Dupont, J., Vitek, A., and White, P.C. (1989). Characterization of two genes encoding human steroid 11-beta-hydroxylase (P-450(11) β). J. Biol. Chem. 264, 20961-20967.
23. Nemani, R., Ghazarian, J.G., Moorthy, B., Wongsurawat, N., Strong, R., and Armbrecht, H.J. (1989). Phosphorylation of ferredoxin and regulation of renal mitochondrial 25-hydroxy-vitamin D-1 α-hydroxylase activity in vitro. J. Biol. Chem. 264, 15361-15366.
24. Okamura, T., John, M.E., Zuber, M.X., Simpson, E.R., and Waterman, M.R. (1985). Molecular cloning and amino acid sequence of the precursor form of bovine adrenodoxin: evidence for a previously unidentified COOH-terminal peptide. Proc. Natl. Acad. Sci. USA 82, 5705-5709.
25. Okazaki, T., Kato, Y., Mochizuki, T., Tashima, M., Sawada, H., and Uchino, H. (1988). Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds. Exp. Hematol. 16, 42-48.
26. Okuda, T., Sawada, H., Kato, Y., Yumoto, Y., Ogawa, K., Tashima, M., and Okuma, M. (1991). Effects of protein kinase A and calcium/phospholipid-dependent kinase modulators in the process of HL-60 cell differentiation: their opposite effects between HL-60 cell and K-562 cell differentiation. Cell Growth Differ. 2, 415-420.
27. Omura, S., Iwai, Y., Hirano, A., Nakagawa, A., Awaya, J., Tsuchya, H., Takahashi, Y., and Masuma, R. (1977). A new alkaloid AM-2282 of Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J. Antibiot. (Tokyo) 30, 275-282.
28. Omura, S., Sasaki, Y., Iwai, Y., and Takeshima, H. (1995). Staurosporine, a potentially important gift from a microorganism. J. Antibiot. (Tokyo) 48, 535-548.
29. Sausville, E.A., Arbuck, S.G., Messmann, R., Headlee, D., Bauer, K.S., Lush, R.M., Murgo, A., Figg, W.D., Lahusen, T., Jaken, S., Jing, X., Roberge, M., Fuse, E., Kuwabara, T., and Senderowicz, A.M. (2001). Phase I trial of 72-h continuous infusion UCN-01 in patients with refractory neoplasms. J. Clin. Oncol. 19, 2319-2333.
30. Schwartz, G.K., Redwood, S.M., Ohnuma, T., Holland, J.F., Droller, M.J., and Liu, B.C. (1990). Inhibition of invasion of invasive human bladder carcinoma cells by protein kinase C inhibitor staurosporine. J. Natl. Cancer Inst. 82, 1753-1756.
31. Shizuta, Y., Kawamoto, T., Mitsuuchi, Y., Miyahara, K., Rosler, A., Ulick, S., and Imura, H. (1995). Inborn errors of aldosterone biosynthesis in humans. Steroids 60, 15-21.
32. Siegel, N., Wongsurawat, N., and Armbrecht, H.J. (1986). Parathyroid hormone stimulates dephosphorylation of the renoredoxin component of the 25-hydroxyvitamin D3-1 α-hydroxylase from rat renal cortex. J. Biol. Chem. 261, 16998-17003.
33. Solish, S.B., Picado-Leonard, J., Morel, Y., Kuhn, R.W., Mohandas, T.K., Hanukoglu, I., and Miller, W.L. (1988). Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen→q25 are expressed in steroidogenic tissues. Proc. Natl. Acad. Sci. USA 85, 7104-7108.
34. Th'ng, J.P., Guo, X.W., Swank, R.A., Crissman, H.A., and Bradbury, E.M. (1994). Inhibition of histone phosphorylation by staurosporine leads to chromosome decondensation. J. Biol. Chem. 269, 9568-9573.
35. Toledo, L.M. and Lydon, N.B. (1997). Structures of staurosporine bound to CDK2 and cAPK - new tools for structure-based design of protein kinase inhibitors. Structure 5, 1551-1556.
36. Ulmschneider, S., Müller-Vieira, U., Mitrenga, M., Hartmann, R.W., Oberwinkler-Marchais, S., Klein, C.D., Bureik, M., Bernhardt, R., Antes, I., and Lengauer, T. (2005). Synthesis and evaluation of imidazolylmethylene-tetrahydronaphthalenes and -indanes: potent inhibitors of aldosterone synthase (CYP11B2). J. Med. Chem. 48, 1796-1805.
37. Utz, I., Hofer, S., Regenass, U., Hilbe, W., Thaler, J., Grunicke, H., and Hofmann, J. (1994). The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance. Int. J. Cancer 57, 104-110.
38. Wolff, T., Distlerath, L.M., Worthington, M.T., Groopman, J.D., Hammons, G.J., Kadlubar, F.F., Prough, R.A., Martin, M.V., and Guengerich, F.P. (1985). Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling. Cancer Res. 45, 2116-2122.
39. 3H]UCN-01 in rats and dogs after intravenous administration. Cancer Chemother. Pharmacol. 47, 106-112.
40. Ye, P., Kenyon, C.J., Mackenzie, S.M., Seckl, J.R., Fraser, R., Connell, J.M., and Davies, E. (2003). Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology 144, 3321-3328.
41. Yue, T.L., Wang, C., Romanic, A.M., Kikly, K., Keller, P., Dewolf, W.E. Jr., Hart, T.K., Thomas, H.C., Storer, B., Gu, J.L., Wang, X., and Feuerstein, G.Z. (1998). Staurosporine-induced apoptosis in cardiomyocytes: a potential role of caspase-3. J. Mol. Cell. Cardiol. 30, 495-507.