Stereoselective synthesis of hydroxylated indolizidines via (-)-sparteine-mediated kinetic resolution coupled with intramolecular carbolithiation

Synlett

Volumn , Issue 7, 1998, Pages 797-800

  Woltering, Michael J ^a   Fröhlich, Roland ^a   Wibbeling, Birgit ^a   Hoppe, Dieter ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 26844521341     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-1761     Document Type: Article

References (55)

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41. 1H NMR NOE experiments. We gratefully thank Dr. Klaus Bergander for the measurements at the 600 MHz NMR spectrometer. (Chemical Equation Presented)
42. 3.
43. 3Si (458.718): Calc.: C 68.08, H 9.23, N 6.11. Found: C 68.48, H 9.42, N 6.07.
44. -3, Flack parameter 0.00(3), hydrogens calculated and refined as riding atoms.
45. Data sets were collected with an Enraf Nonius CAD4 diffractometer. Programs used: data reduction MolEN, structure solution SHELXS-86, structure refinement SHELXL-93, graphics SCHAKAL-92. Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the number: 101328 at the Cambridge Crystallographic Data Centre as supplementary publication. Copies of the data can be obtained free of charge on application to The Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: int. code +44(1223)336-033, e-mail: deposit@ccdc.cam.ac.uk].
46. -3, hydrogens calculated and refined as riding atoms.
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54. Little is known about the stereochemistry of the substitution in carbon-substituted benzyllithium compounds; a different reaction pattern cannot be strictly excluded.
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