Models to explain fatigue during prolonged endurance cycling

Sports Medicine

Volumn 35, Issue 10, 2005, Pages 865-898

  Abbiss, Chris R ^a   Laursen, Paul B ^a  

^a EDITH COWAN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; LACTIC ACID;

ARTICLE; CELL VOLUME; CYCLING; ELECTROMYOGRAPHY; ENDURANCE; ENERGY; ENVIRONMENTAL FACTOR; ERYTHROCYTE; EXERCISE; FATIGUE; HEART OUTPUT; HUMAN; MEDICAL RESEARCH; METABOLIC CAPACITY; MUSCLE BLOOD FLOW; MUSCLE CONTRACTION; MUSCLE INJURY; MUSCLE STRENGTH; MUSCLE STRETCHING; MUSCLE WEAKNESS; NONLINEAR SYSTEM; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PLASMA VOLUME; PSYCHOLOGICAL ASPECT; STATISTICAL MODEL; TASK PERFORMANCE; THERMOREGULATION;

BICYCLING; BIOMECHANICS; BODY TEMPERATURE REGULATION; BRAIN; ENERGY METABOLISM; EXERCISE TOLERANCE; HUMANS; LACTIC ACID; MODELS, BIOLOGICAL; MUSCLE FATIGUE; MUSCLE, SKELETAL; PERIPHERAL NERVOUS SYSTEM; TIME FACTORS;

EID: 26844471344     PISSN: 01121642     EISSN: 01121642     Source Type: Journal    
DOI: 10.2165/00007256-200535100-00004     Document Type: Article

References (224)

1. Lucia A, Hoyos J, Chicharro JL. Physiology of professional road cycling. Sports Med 2001; 31 (5): 325-37
2. Lucia A, Hoyos J, Santalla A, et al. Tour de France versus Vuelta a Espana: which is harder? Med Sci Sports Exerc 2003; 35 (5): 872-8
3. de Koning JJ, Bobbert MF, Foster C. Determination of optimal pacing strategy in track cycling with an energy flow model. J Sci Med Sport 1999; 2 (3): 266-77
4. Nikolopoulos V, Arkinstall MJ, Hawley JA. Pacing strategy in simulated cycle time-trials is based on perceived rather than actual distance. J Sci Med Sport 2001; 4 (2): 212-9
5. Padilla S, Mujika I, Orbananos J, et al. Exercise intensity during competition time trials in professional road cycling. Med Sci Sports Exerc 2000; 32 (4): 850-6
6. Jeukendrup AE, Craig NP, Hawley JA. The bioenergetics of World Class Cycling. J Sci Med Sport 2000; 3 (4): 414-33
7. Lucia A, Hoyos J, Carvajal A, et al. Heart rate response to professional road cycling: the Tour de France. Int J Sports Med 1999; 20: 167-72
8. Lucia A, Joyos H, Chicharro JL. Physiological response to professional road cycling: climbers vs. time trialists. Int J Sports Med 2000; 21: 505-12
9. Balmer J, Davison RC, Bird SR. Peak power predicts perform-ance power during an outdoor 16.1-km cycling time trial. Med Sci Sports Exerc 2000; 32 (8): 1485-90
10. Laursen PB, Shing CM, Jenkins DG. Reproducibility of a laboratory-based 40km cycle time-trial on a stationary wind-trainer in highly trained cyclists. Int J Sports Med 2003; 24 (7): 481-5
11. Kay D, Marino FE, Cannon J, et al. Evidence for neuromuscular fatigue during high-intensity cycling in warm, humid conditions. Eur J Appl Physiol 2001; 84 (1-2): 115-21
12. Garside I, Doran DA. Effects of bicycle frame ergonomics on triathlon 10km running performance. J Sports Sci 2000; 18 (10): 825-33
13. Candau RB, Grappe F, Menard M, et al. Simplified deceleration method for assessment of resistive forces in cycling. Med Sci Sports Exerc 1999; 31 (10): 1441-7
14. Hill AV, Long CHH, Lupton H. Muscular exercise, lactic acid, and the supply and utilisation of oxygen: parts I-III. Proc R Soc Br 1924; 97: 155-76
15. Noakes TD. Physiological models to understand exercise fatigue and the adaptations that predict or enhance athletic performance. Scand J Med Sci Sports 2000; 10 (3): 123-45
16. Brooks G, Fahey T, White T, et al. Fatigue during muscular exercise. In: Sordi M, Kirschenbaum CW, Ohlenroth P, editors. Exercise physiology: human bioenergetics and its applications. 3rd ed. Sydney: McGraw Hill, 2000: 800-22
17. Hampson DB, St Clair Gibson A, Lambert MI, et al. The influence of sensory cues on the perception of exertion during exercise and central regulation of exercise performance. Sports Med 2001; 31 (13): 935-52
18. Hunter AM, St Clair Gibson A, Lambert MI, et al. Effects of supramaximal exercise on the electromyographic signal. Br J Sports Med 2003; 37 (4): 296-9
19. Cairns SP, Knicker AJ, Thompson MW, et al. Evaluation of models used to study neuromuscular fatigue. Exerc Sport Sci Rev 2005; 33 (1): 9-16
20. Tordi N, Perrey S, Harvey A, et al. Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans. J Appl Physiol 2003; 94 (2): 533-41
21. Noakes TD, St Clair Gibson A. Logical limitations to the "catastrophe" models of fatigue during exercise in humans. Br J Sports Med 2004; 38: 648-9
22. St Clair Gibson A, Noakes TD. Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans. Br J Sports Med 2004; 38: 797-806
23. Lambert M, St Clair Gibson A, Noakes TD. Complex systems model of fatigue: integrative homeostatic control of peripheral physiological systems during exercise in humans. Br J Sports Med 2005; 39: 52-62
24. Millet GY, Millet GP, Lattier G, et al. Alteration of neuromuscular function after a prolonged road cycling race. Int J Sports Med 2003; 24 (3): 190-4
25. Allman BL, Rice CL. Neuromuscular fatigue and aging: central and peripheral factors. Muscle Nerve 2002; 25 (6): 785-96
26. Kayser B. Exercise starts and ends in the brain. Eur J Appl Physiol 2003; 90: 441-9
27. Green HJ. Mechanisms of muscle fatigue in intense exercise. J Sports Sci 1997; 15 (3): 247-56
28. Kay D, Marino FE. Fluid ingestion and exercise hyperthermia: implications for performance, thermoregulation, metabolism and the development of fatigue. J Sports Sci 2000; 18 (2): 71-82
29. Wilmore JH, Costill DL. Physiology of sport and exercise. 2nd ed. Champagin (IL): Human Kinetics, 1999
30. Millet G, Lepers R, Lattier G, et al. Influence of ultra-long-term fatigue on the oxygen cost of two types of locomotion. Eur J Appl Physiol 2000; 83 (4 -5): 376-80
31. Millet GY, Lepers R, Maffiuletti NA, et al. Alterations of neuromuscular function after an ultramarathon. J Appl Physiol 2002; 92 (2): 486-92
32. Pinniger GJ, Steele JR, Groeller H. Does fatigue induced by repeated dynamic efforts affect hamstring muscle function? Med Sci Sports Exerc 2000; 32 (3): 647-53
33. St Clair Gibson A, Lambert MI, Noakes TD. Neural control of force output during maximal and submaximal exercise. Sports Med 2001; 31 (9): 637-50
34. Gabriel DA, Basford JR, An KN. Neural adaptations to fatigue: implications for muscle strength and training. Med Sci Sports Exerc 2001; 33 (8): 1354-60
35. Lepers R, Hausswirth C, Maffiuletti N, et al. Evidence of neuromuscular fatigue after prolonged cycling exercise. Med Sci Sports Exerc 2000; 32 (11): 1880-6
36. Lepers R, Maffiuletti NA, Rochette L, et al. Neuromuscular fatigue during a long-duration cycling exercise. J Appl Physiol 2002; 92 (4): 1487-93
37. Paasuke M, Ereline J, Gapeyeva H. Neuromuscular fatigue during repeated exhaustive submaximal static contractions of knee extensor muscles in endurance-trained, power-trained and untrained men. Acta Physiol Scand 1999; 166 (4): 319-26
38. Kay D, St Clair Gibson A, Mitchell MJ, et al. Different neuromuscular recruitment patterns during eccentric, concentric and isometric contractions. J Electromyogr Kinesiol 2000; 10 (6): 425-31
39. Rodacki AL, Fowler NE, Bennett SJ. Multi-segment coordination: fatigue effects. Med Sci Sports Exerc 2001; 33 (7): 1157-67
40. Lepers R, Millet GY, Maffiuletti NA, et al. Effect of pedalling rates on physiological response during endurance cycling. Eur J Appl Physiol 2001; 85 (3-4): 392-5
41. Noakes TD, Peltonen JE, Rusko HK. Evidence that a central governor regulates exercise performance during acute hypoxia and hyperoxia. J Exp Biol 2001; 204 (Pt 18): 3225-34
42. Ainsworth BE, Serfass RC, Leon AS. Effects of recovery duration and blood lactate level on power output during cycling. Can J Appl Physiol 1993; 18 (1): 19-30
43. Bilodeau M, Henderson TK, Nolta BE, et al. Effect of aging on fatigue characteristics of elbow flexor muscles during sustained submaximal contraction. J Appl Physiol 2001; 91 (6): 2654-64
44. Brooks G, Fahey T, White T, et al. Cardiovascular dynamics during exercise. In: Sordi M, Kirschenbaum CW, Ohlenroth P, editors. Exercise physiology: human bioenergetics and its applications. 3rd ed. Sydney: McGraw Hill, 2000: 317-36
45. Delp MD, Laughlin MH. Regulation of skeletal muscle perfusion during exercise. Acta Physiol Scand 1998; 162: 411-9
46. Saltin B, Radegran G, Koskolou MD, et al. Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol Scand 1998; 162: 421-36
47. Radegran G, Blomstrand E, Saltin B. Peak muscle perfusion and oxygen uptake in humans: importance of precise estimates of muscle mass. J Appl Physiol 1999; 87 (6): 2375-80
48. MacDougall JD, Wenger HA, Green HJ. Physiology testing of the high-performance athlete. 2nd ed. Champaign (IL): Human Kinetics Books, 1991
49. Gissane C, Corrigan DL, White JA. Gross efficiency responses to exercise conditioning in adult males of various ages. J Sports Sci 1991; 9 (3): 383-91
50. Lucia A, Hoyos J, Santalla A, et al. Kinetics of VO(2) in professional cyclists. Med Sci Sports Exerc 2002; 34 (2): 320-5
51. 2max and economy/efficiency in world-class cyclists. Med Sci Sports Exerc 2002; 34 (2): 2079-84
52. Faulkner JA, Heigenhauser GF, Schork MA. The cardiac output: oxygen uptake relationship of men during graded bicycle ergometry. Med Sci Sports Exerc 1977; 9 (3): 148-54
53. Tonkonogi M, Sahlin K. Rate of oxidative phosphorylation in isolated mitochondria from human skeletal muscle: effect of training status. Acta Physiol Scand 1997; 161: 345-53
54. Hahn AG, Gore CJ. The effects of altitude on cycling performance. Sports Med 2001; 31 (7): 533-57
55. 2max, and performance of elite cyclists. Med Sci Sports Exerc 1999; 31 (6): 800-8
56. Coyle EF, Hemmert MK, Coggan AR. Effects of detraining on cardiovascular response to exercise: role of blood volume. J Appl Physiol 1986; 60 (1): 95-9
57. de Vries H, Housh T. Physiology of exercise: for physical education, athletics and exercise science. 5th ed. Dubque: Brown and Benchmark, 1994
58. Powers S, Howley E, editors. Exercise physiology: theory and application to fitness and performance. Dubuque: Brown and Benchmark, 1997
59. Hoogsteen J, Hoogeveen A, Schaffers H, et al. Left atrial and ventricular dimensions in highly trained cyclists. Int J Cardiovasc Imaging 2003; 19 (3): 211-7
60. Lucia A, Carvajal A, Boraita A, et al. Heart dimensions may influence the occurrence of the heart rate deflection point in highly trained cyclists. Br J Sports Med 1999; 33 (6): 387-92
61. Gonzàlez-Alonso J, Calbet JA. Reductions in systemic and skeletal muscle blood flow and oxygen delivery limit maximal aerobic capacity in humans. Circulation 2003; 107 (6): 824-30
62. Calbet JA, Jensen-Urstad M, van Hall G, et al. Maximal muscular vascular conductances during whole body upright exercise in humans. J Physiol 2004; 558 (1): 319-31
63. Levine BD, Stray-Gundersen J. 'Living high-training low': effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 1997; 83 (1): 102-12
64. Coyle EF, Hopper MK, Coggan AR. Maximal oxygen uptake relative to plasma volume expansion. Int J Sports Med 1990; 11 (2): 116-9
65. Marx JJ, Vergouwen PC. Packed-cell volume in elite athletes [letter]. Lancet 1998; 352 (9126): 451
66. McArdle WD, Katch FI, Katch VL. Exercise physiology: energy, nutrition, and human performance. Baltimore (MD): Lippincott Williams and Wilkins, 2001
67. Birchard K. Why doctors should worry about doping in sport. Lancet 1998; 352 (9121): 42
68. Saris WH, Senden JM, Brouns F. What is a normal red-blood cell mass for professional cyclists? [letter]. Lancet 1998; 352 (9142): 1758
69. International Cycling Union. UCI Cycling Regulations. Lausanne: International Cycling Union, 2004
70. Blomstrand E, Radegran G, Saltin B. Maximum rate of oxygen uptake by human skeletal muscle in relation to maximal activities of enzymes in the Krebs cycle. J Physiol 1997; 501: 455-60
71. Takaishi T, Sugiura T, Katayama K, et al. Changes in blood volume and oxygenation level in a working muscle during a crank cycle. Med Sci Sports Exerc 2002; 33 (3): 520-8
72. Takaishi T, Ishida K, Katayama K, et al. Effect of cycling experience and pedal cadence on the near-infrared spectroscopy parameters. Med Sci Sports Exerc 2002; 34 (12): 2062-71
73. Gotshall RW, Bauer TA, Fahrner SL. Cycling cadence alters exercise hemodynamics. Int J Sports Med 1996; 17 (1): 17-21
74. Bizeau ME, Wills WT, Hazel JR. Differential responses to endurance training in subsarcolemmal and intermyofibrillar mitochondria. J Appl Physiol 1998; 85 (4): 1279-84
75. Tonkonogi M, Walsh B, Svensson M, et al. Mitochondrial function and antioxidative defence in human muscle: effects of endurance training and oxidative stress. J Physiol 2000; 528 (2): 379-88
76. Walsh B, Tonkonogi M, Sahlin K. Effects of endurance training on oxidative and antioxidative function in human permeabilized muscle fibres. Pflugers Arch 2001; 442: 420-5
77. Hood DA, Takahashi M, Connor MK, et al. Assembly of the cellular powerhouse: current issues in muscle mitochondrial biogenesis. Exerc Sport Sci Rev 1999; 28 (2): 68-73
78. Hoppeler H, Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sports Exerc 2003; 35 (1): 95-104
79. Pringle JS, Doust JH, Carter H, et al. Oxygen uptake kinetics during moderate, heavy and severe intensity 'submaximal' exercise in humans: the influence of muscle fibre type and capillarisation. Eur J Appl Physiol 2003; 89 (3-4): 289-300
80. Kraus RM, Stallings III HW, Yeager RC, et al. Circulating plasma VEGF response to exercise in sedentary and endurance-trained men. J Appl Physiol 2004; 96 (4): 1445-50
81. Tonkonogi M, Sahlin K. Physical exercise and mitochondrial function in human skeletal muscle. Exerc Sport Sci Rev 2002; 30 (3): 129-37
82. Kirkenall DT, Garrett WE. The effects of aging and training on skeletal muscle. Am J Sports Med 1998; 26 (4): 598-63
83. Pette D. Training effects on the contractile apparatus. Acta Physiol Scand 1998; 162: 367-76
84. Lucia A, Pardo J, Durantez A, et al. Physiological differences between professional and elite road cyclists. Int J Sports Med 1998; 19 (5): 342-8
85. Liedl MA, Swain DP, Branch JD. Physiological effects of constant versus variable power during endurance cycling. Med Sci Sports Exerc 1999; 31 (10): 1472-7
86. Walton DM, Kuchinad RA, Ivanova TD, et al. Reflex inhibition during muscle fatigue in endurance-trained and sedentary individuals. Eur J Appl Physiol 2002; 87: 462-8
87. Juel C. Muscle pH regulation: role of training. Acta Physiol Scand 1998; 162: 359-66
88. Bogdanis GC, Nevill ME, Lakomy HK. Effects of previous dynamic arm exercise on power output during repeated maximal sprint cycling. J Sports Sci 1994; 12 (4): 363-70
89. Martini F. Fundamentals of anatomy and physiology. 5th ed. Upper Saddle River (NJ): Prentice-Hall, 2001
90. Stepto NK, Martin DT, Fallon KE, et al. Metabolic demands of intense aerobic interval training in competitive cyclists. Med Sci Sports Exerc 2001; 33 (2): 303-10
91. Stackhouse SK, Reisman DS, Binder-Macleod SA. Challenging the role of pH in skeletal muscle fatigue. Phys Ther 2001; 81 (12): 1897-903
92. Hill CA, Thompson MW, Ruell PA, et al. Sarcoplasmic reticulum function and muscle contractile character following fatiguing exercise in humans. J Physiol 2001; 531 (3): 871-8
93. Davis JM, Bailey SP. Possible mechanisms of central nervous system fatigue during exercise. Med Sci Sports Exerc 1997; 29 (1): 45-57
94. Weston AR, Myburgh KH, Lindsay FH, et al. Skeletal muscle buffering capacity and endurance performance after high-intensity interval training by well-trained cyclists. Eur J Appl Physiol 1997; 75 (1): 7-13
95. Santalla A, Perez M, Montilla M, et al. Sodium bicarbonate ingestion does not alter the slow component of oxygen uptake kinetics in professional cyclists. J Sports Sci 2003; 21 (1): 39-47
96. Westerblad H, Allen DG, Lannergren J. Muscle fatigue: lactic acid or inorganic phosphate the major cause? News Physiol Sci 2002; 17: 17-21
97. Bangsbo J, Madsen K, Kiens B, et al. Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man. J Physiol 1996; 495 (2): 587-96
98. Brooks GA. Lactate doesn't necessarily cause fatigue: why are we surprised? J Physiol 2001; 536 (1): 1
99. Allen D, Westerblad H. Physiology. Lactic acid: the latest performance-enhancing drug. Science 2004; 305 (5687): 1112-3
100. Pedersen TH, Nielsen OB, Lamb GD, et al. Intracellular acidosis enhances the excitability of working muscle. Science 2004; 305 (5687): 1144-7
101. Nielsen OB, de Paoli F, Overgaard K. Protective effects of lactic acid on force production in rat skeletal muscle. J Physiol 2001; 536 (1): 161-6
102. Shulman RG, Rothman DL. The 'glycogen shunt' in exercising muscle: a role for glycogen in muscle energetics and fatigue. Proc Natl Acad Sci U S A 2001; 98 (2): 457-61
103. Vissing J, Haller RG. The effect of oral sucrose on exercise tolerance in patients with McArdle's disease. N Engl J Med 2003; 349 (26): 2503-8
104. Nielsen JN, Wojtaszewski JFP, Haller RG, et al. Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease. J Physiol 2002; 541 (3): 979-89
105. Haller RG, Vissing J. Spontaneous 'second wind' and glucose-induced second 'second wind' in McArdle disease. Arch Neurol 2002; 59 (9): 1395-402
106. Kazemi-Esfarjani P, Skomorowska E, Jensen T, et al. A nonischemic forearm exercise test for McArdle disease. Ann Neurol 2002; 52: 153-9
107. Wojtaszewski JFP, Richter EA. Glucose utilization during exercise: influence of endurance training. Acta Physiol Scand 1998; 162: 351-8
108. Hellsten Y, Apple FS, Sjodin B. Effect of sprint cycle training on activities of antioxidant enzymes in human skeletal muscle. J Appl Physiol 1996; 81 (4): 1484-7
109. Burke ER, Cerny F, Costill D, et al. Characteristics of skeletal muscle in competitive cyclists. Med Sci Sports Exerc 1977; 9 (2): 109-12
110. Davis JM, Alderson NL, Welsh RS. Serotonin and central nervous system fatigue: nutritional considerations. Am J Clin Nutr 2000; 72 (2 Suppl.): 573S-8S
111. Coyle EF, Montain SJ. Carbohydrate and fluid ingestion during exercise: are there trade-offs? Med Sci Sports Exerc 1992; 24 (6): 671-8
112. St Clair Gibson A, Schabort EJ, Noakes TD. Reduced neuromuscular activity and force generation during prolonged cycling. Am J Physiol Regul Integr Comp Physiol 2001; 281 (1): R187-96
113. Dennis SC, Noakes TD, Hawley JA. Nutritional strategies to minimize fatigue during prolonged exercise: fluid, electrolyte and energy replacement. J Sports Sci 1997; 15 (3): 305-13
114. Gigli I, Bussmann LE. Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats. Physiol Res 2002; 51 (3): 247-54
115. Mena P, Mayner M, Campillo JE. Plasma lipid concentrations in professional cyclists after competitive cycle races. Eur J Appl Physiol Occup Physiol 1991; 62: 349-52
116. Hawley JA. Symposium: limits to fat oxidation by skeletal muscle during exercise - introduction. Med Sci Sports Exerc 2002; 34 (9): 1475-6
117. Hawley JA, Palmer GS, Noakes TD. Effects of 3 days of carbohydrate supplementation on muscle glycogen content and utilisation during a 1-h cycling performance. Eur J Appl Physiol 1997; 75 (5): 407-12
118. Garcia-Roves PM, Terrados N, Fernandez SF, et al. Macronutrients intake of top level cyclists during continuous competition: change in the feeding pattern. Int J Sport Med 1998; 19 (1): 61-7
119. Fitts RH. Cellular mechanisms of muscle fatigue. Physiol Rev 1994; 74: 49-94
120. Stackhouse SK, Dean JC, Lee SCK. Measurement of central activation failure of the quadriceps femoris in healthy adults. Muscle Nerve 2000; 23: 1706-12
121. Avela J, Kyrolainen H, Komi PV. Neuromuscular changes after long-lasting mechanical and electrically elicited fatigue. Eur J Appl Physiol 2001; 85: 317-25
122. Hunter AM, St Clair Gibson A, Lambert M, et al. Electromyographic (EMG) normalization method for cycle fatigue protocols. Med Sci Sports Exerc 2002; 34 (5): 857-61
123. Hug F, Laplaud D, Savin B, et al. Occurrence of electromyographic and ventilatory thresholds in professional road cyclists. Eur J Appl Physiol 2003; 90: 643-6
124. Hausswirth C, Brisswalter J, Vallier JM, et al. Evolution of electromyographic signal, running economy, and perceived exertion during different prolonged exercises. Int J Sports Med 2000; 21 (6): 429-36
125. de Ruiter CJ, Jongen PJ, van der Woude LH, et al. Contractile speed and fatigue of adductor pollicis muscle in multiple sclerosis. Muscle Nerve 2001; 24 (9): 1173-80
126. O'Brien PM, O'Connor PJ. Effect of bright light on cycling performance. Med Sci Sports Exerc 2000; 32 (2): 439-47
127. O'Connor PJ, Cook DB. Moderate-intensity muscle pain can be produced and sustained during cycle ergometry. Med Sci Sports Exerc 2001; 33 (6): 1046-51
128. Tikuisis P, McLellan TM, Selkirk G. Perceptual versus physiological heat strain during exercise-heat stress. Med Sci Sports Exerc 2002; 34 (9): 1454-61
129. Stackhouse SK, Stevens JE, Lee SCK, et al. Maximum voluntary activation in the nonfatigued and fatigued muscle of young and old individuals. Phys Ther 2001; 81 (5): 1102-9
130. Gandevia SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 2001; 81 (4): 1725-89
131. Nielsen OB, Clausen T. The Na+/K(+)-pump protects muscle excitability and contractility during exercise. Exerc Sport Sci Rev 2000; 28 (4): 159-64
132. Fowles JR, Green HJ, Tupling R, et al. Human neuromuscular fatigue is associated with altered Na+-K+-ATPase activity following isometric exercise. J Appl Physiol 2002; 92 (4): 1585-93
133. Rassier DE, MacIntosh BR. Coexistence of potentiation and fatigue in skeletal muscle. Braz J Med Biol Res 2000; 33: 499-508
134. Hunter SK, Duchateau J, Enoka RM. Muscle fatigue and the mechanisms of task failure. Exerc Sport Sci Rev 2004; 32 (2): 44-9
135. Hunter SK, Ryan DL, Ortega JD, et al. Task differences with the same load torque alter the endurance time of submaximal fatiguing contractions in humans. J Neurophysiol 2002; 88 (6): 3087-96
136. Harnada T, Sale DG, MacDougall JD, et al. Interaction of fibre type, potentiation and fatigue in human knee extensor muscles. Acta Physiol Scand 2003; 178: 165-73
137. Oba T, Ishikawa T, Takaishi T, et al. Hydrogen peroxide decelerates recovery of action potential after high-frequency fatigue in skeletal muscle. Muscle Nerve 2000; 23 (10): 1515-24
138. McKenna MJ, Harmer AR, Fraser SF, et al. Effects of training on potassium, calcium and hydrogen ion regulation in skeletal muscle and blood during exercise. Acta Physiol Scand 1996; 156: 335-46
139. Green H, Dahly A, Shoemaker K, et al. Serial effects of high-resistance and prolonged endurance training on Na+-K+ pump concentration and enzymatic activities in human vastus lateralis. Acta Physiol Scand 1999; 165 (2): 177-84
140. Ray CA, Gracey KH. Augmentation of exercise-induced muscle sympathetic nerve activity during muscle heating. J Appl Physiol 1997; 82 (6): 1719-25
141. Bigard AX, Sanchez H, Claveyrolas G, et al. Effects of dehydration and rehydration on EMG changes during fatiguing contractions. Med Sci Sports Exerc 2001; 33 (10): 1694-700
142. Gollhofer A, Komi PV, Fujitsuka N, et al. Fatigue during stretch-shortening cycle exercises II: changes in neuromuscular activation patterns of human skeletal muscle. Int J Sports Med 1987; 8 Suppl. 1: 38-47
143. Hermann KM, Barnes WS. Effects of eccentric exercise on trunk extensor torque and lumbar paraspinal EMG. Med Sci Sports Exerc 2001; 33 (6): 971-7
144. Pringle JS, Jones AM. Maximal lactate steady state, critical power and EMG during cycling. Eur J Appl Physiol 2002; 88 (3): 214-26
145. Westgaard RH, de Luca CJ. Motor unit substitution in long-duration contractions of the human trapezius muscle. J Neurophysiol 1999; 82 (1): 501-4
146. Maganaris CN, Baltzopoulos V, Ball D, et al. In vivo specific tension of human skeletal muscle. J Appl Physiol 2001; 90: 865-72
147. Hamlin MJ, Quigley BM. Quadriceps concentric and eccentric exercise 2: differences in muscle strength, fatigue and EMG activity in eccentrically- exercised sore and non-sore muscles. J Sci Med Sport 2001; 4 (1): 104-15
148. Hamlin MJ, Quigley BM. Quadriceps concentric and eccentric exercise 1: changing in contractile and electrical activity following eccentric and concentric exercise. J Sci Med Sport 2001; 4 (1): 88-103
149. del Aguila LF, Claffey KP, Kirwan JP. TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells. Am J Physiol 1999; 276 (5 Pt 1): E849-55
150. Komi PV. Stretch-shortening cycle: a powerful model to study normal and fatigued muscle. J Biomech 2000; 33 (10): 1197-206
151. Nosaka K, Lavender A, Newton M, et al. Muscle damage in resistance training: is muscle damage necessary for strength gain and muscle hypertrophy? Int J Sport Health Sci 2003; 1 (1): 1-8
152. Nicol C, Kuitunen S, Kyrolainen H, et al. Effects of long- and short-term fatiguing stretch-shortening cycle exercises on reflex EMG and force of the tendon-muscle complex. Eur J Appl Physiol 2003; 90: 470-9
153. Lucia A, San Juan AF, Montilla M, et al. In professional road cyclists, low pedaling cadences are less efficient. Med Sci Sports Exerc 2004; 36 (6): 1048-54
154. Ciubotariu A, Arendt-Nielsen L, Graven-Nielsen T. The influence of muscle pain and fatigue on the activity of synergistic muscles of the leg. Eur J Appl Physiol 2004; 91: 604-14
155. Mena P, Mayner M, Campillo JE. Changes in plasma enzyme activities in professional racing cyclists. Br J Sports Med 1996; 30 (2): 122-4
156. Proske U, Morgan DL. Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications. J Physiol 2001; 537 (2): 333-45
157. Gibala MJ, MacDougall JD, Tarnopolsky MA, et al. Changes in human skeletal muscle ultra-structure and force production after acute resistance exercise. J Appl Physiol 1995; 78: 702-8
158. Gibala MJ, Interisano SA, Tarnopolsky MA, et al. Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men. Can J Appl Physiol Pharmacol 2000; 78 (8): 656-61
159. Darnley GM, Duke AM, Steele DS, et al. Effects of reactive oxygen species on aspects of excitation-contraction coupling in chemically skinned rabbit diaphragm muscle fibres. Exp Physiol 2001; 86 (2): 161-8
160. Hausswirth C, Bigard AX, Guezennec CY. Relationship between running mechanics and energy cost of running at the end of a triathlon and a marathon. Int J Sports Med 1997; 18 (5): 330-9
161. Passfield L, Doust JH. Changes in cycling efficiency and performance after endurance exercise. Med Sci Sports Exerc 2000; 32 (11): 1935-41
162. Takaishi T, Yamamoto T, Ono T, et al. Neuromuscular, metabolic, and kinetic adaptations for skilled pedaling performance in cyclists. Med Sci Sports Exerc 1998; 30 (3): 442-9
163. MacIntosh BR, Neptune RR, Horton JF. Cadence, power, and muscle activation in cycle ergometry. Med Sci Sports Exerc 2000; 32 (7): 1281-7
164. Millet GP, Tronche C, Fuster N, et al. Level ground and uphill cycling efficiency in seated and standing positions. Med Sci Sports Exerc 2002; 34 (10): 1645-52
165. Jeukendrup A, Martin DT, Gore CJ. Are world-class cyclists really more efficient? [letter]. Med Sci Sports Exerc 2003; 35 (7): 1238-9
166. Padilla S, Mujika I, Angulo F, et al. Scientific approach to the 1-h cycling world record: a case study. J Appl Physiol 2000; 89: 1522-7
167. Lucia A, Hoyos J, Santalla MPA, et al. Response-unique adaptations are to be expected in leading world cyclists [letter]. Med Sci Sports Exerc 2003; 35 (7): 1240-1
168. Weston AR, Mbambo Z, Myburgh KH. Running economy of African and Caucasian distance runners. Med Sci Sports Exerc 2000; 32 (6): 1130-4
169. Weston AR, Karamizrak O, Smith A, et al. African runners exhibit greater fatigue resistance, lower lactate accumulation, and higher oxidative enzyme activity. J Appl Physiol 1999; 86 (3): 915-23
170. Cherry PW, Lakomy HK, Nevill ME, et al. Effect of the number of preceding muscle actions on subsequent peak power output. J Sports Sci 1997; 15 (2): 201-6
171. Coyle EF, Sidossis LS, Horowitz JF, et al. Cycling efficiency is related to the percentage of type I muscle fibers. Med Sci Sports Exerc 1992; 24 (7): 782-8
172. Bull AJ, Housh TJ, Johnson GO, et al. Electromyographic and mechanomyographic responses at critical power. Can J Appl Physiol 2000; 25 (4): 262-70
173. 2 slow component? Med Sci Sports Exerc 2003; 35 (1): 50-7
174. Hug F, Faucher M, Kipson N, et al. EMG signs of neuromuscular fatigue related to the ventilatory threshold during cycling exercise. Clin Physiol Funct Imaging 2003; 23 (4): 208-14
175. Lucia A, Sanchez O, Carvajal A, et al. Analysis of the aerobic-anaerobic transition in elite cyclists during incremental exercise with the use of electromyography. Br J Sports Med 1999; 33: 178-85
176. Horowitz JF, Sidossis LS, Coyle EF. High efficiency of type I muscle fibers improves performance. Int J Sports Med 1994; 15 (3): 152-7
177. Saunders MJ, Evans EM, Arngrimsson SA, et al. Muscle activation and the slow component rise in oxygen uptake during cycling. Med Sci Sports Exerc 2000; 32 (12): 2040-5
178. Gregory JE, Brockett CL, Morgan DL, et al. Effect of eccentric muscle contractions on Golgi tendon organ responses to passive and active tension in the cat. J Physiol 2002; 538 (1): 209-18
179. Hutton RS, Nelson DL. Stretch sensitivity of Golgi tendon organs in fatigued gastrocnemius muscle [published erratum appears in Med Sci Sports Exerc 1986 Apr; 18 (2): 251]. Med Sci Sports Exerc 1986; 18 (1): 69-74
180. Cafarelli E. Peripheral contributions to the perception of effort. Med Sci Sports Exerc 1982; 14 (5): 382-9
181. Kay D, Taaffe DR, Marino FE. Whole-body pre-cooling and heat storage during self-paced cycling performance in warm humid conditions. J Sports Sci 1999; 17 (12): 937-44
182. Hargreaves M, Febbraio M. Limits to exercise performance in the heat. Int J Sports Med 1998; 19 Suppl. 2: S115-6
183. Gleeson M. Temperature regulation during exercise. Int J Sports Med 1998; 19: S96-9
184. Moran DS. Potential applications of heat and cold stress indices to sporting events. Sports Med 2001; 31 (13): 909-17
185. Nielsen B. Heat acclimation: mechanisms of adaptation to exercise in the heat. Int J Sports Med 1998; 19 Suppl. 2: S154-6
186. Hunter AM, St Clair Gibson A, Mbambo Z, et al. The effects of heat stress on neuromuscular activity during endurance exercise. Pflugers Arch 2002; 444 (6): 738-43
187. Tucker R, Rauch L, Harley YXR, et al. Impaired exercise performance in the heat is associated with an anticipatory reduction in skeletal muscle recruitment. Pflugers Arch 2004 Jul; 448 (4): 422-30
188. Marino FE, Mbambo Z, Kortekaas E, et al. Advantages of smaller body mass during distance running in warm, humid environments. Pflugers Arch 2000; 441: 359-67
189. Nielsen B, Hales JR, Strange S, et al. Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot, dry environment. J Physiol 1993; 460: 467-85
190. Cheuvront SN, Haymes EM. Thermoregulation and marathon running: biological and environmental influences. Sports Med 2001; 31 (10): 743-62
191. Tatterson AJ, Hahn AG, Martin DT, et al. Effects of heat stress on physiological responses and exercise performance in elite cyclists. J Sci Med Sport 2000; 3 (2): 186-93
192. Marino FE, Kay D, Cannon J, et al. A reproducible and variable intensity cycling performance protocol for warm conditions. J Sci Med Sport 2002; 5 (2): 95-107
193. Yoshida T, Nagashima K, Nose H, et al. Relationship between aerobic power, blood volume, and thermoregulatory responses to exercise-heat stress. Med Sci Sports Exerc 1997; 29 (7): 867-73
194. Cochrane DJ, Sleivert GG. Do changing patterns of heat and humidity influence thermoregulation and endurance performance? J Sci Med Sport 1999; 2 (4): 322-32
195. Febbraio MA. Does muscle function and metabolism affect exercise performance in the heat? Exerc Sport Sci Rev 2000; 28 (4): 171-6
196. Watt MJ, Garnham AP, Febbraio MA, et al. Effect of acute plasma volume expansion on thermoregulation and exercise performance in the heat. Med Sci Sports Exerc 2000; 32 (5): 958-62
197. Gray S, Nimmo M. Effects of active, passive or no warm-up on metabolism and performance during high-intensity exercise. J Sports Sci 2001; 19 (9): 693-700
198. Armstrong LE, Maresh CM. Effects of training, environment, and host factors on the sweating response to exercise. Int J Sports Med 1998; 19 Suppl. 2: S103-5
199. Duffield R, Dawson B, Bishop D, et al. Effect of wearing an ice cooling jacket on repeat sprint performance in warm/humid conditions. Br J Sports Med 2003; 37 (2): 164-9
200. Nielsen B, Strange S, Christensen NJ, et al. Acute and adaptive responses in humans to exercise in a warm, humid environment. Pflugers Arch 1997; 434: 49-56
201. Armada-da-Silva PA, Woods J, Jones DA. The effect of passive heating and face cooling on perceived exertion during exercise in the heat. Eur J Appl Physiol 2004; 91 (5-6): 563-71
202. Nybo L, Nielsen B. Perceived exertion is associated with an altered brain activity during exercise with progressive hyperthermia. J Appl Physiol 2001; 91 (5): 2017-23
203. Gonzalez-Alonso J, Teller C, Andersen SL, et al. Influence of body temperature on the development of fatigue during prolonged exercise in the heat. J Appl Physiol 1999; 86 (3): 1032-9
204. Nybo L, Nielsen B. Middle cerebral artery blood velocity is reduced with hyperthermia during prolonged exercise in humans. J Physiol 2001; 534 (Pt 1): 279-86
205. Nybo L, Moller K, Volianitis S, et al. Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans. J Appl Physiol 2002; 93 (1): 58-64
206. Nielsen B, Hyldig T, Bidstrup F, et al. Brain activity and fatigue during prolonged exercise in the heat. Pflugers Arch 2001; 442 (1): 41-8
207. 2 kinetics during intense exercise. J Appl Physiol 2001; 90 (3): 1057-64
208. Ide K, Pott F, Van Lieshout JJ, et al. Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass. Acta Physiol Scand 1998; 162 (1): 13-20
209. Gray SC, Devito G, Nimmo MA. Effect of active warm-up on metabolism prior to and during intense dynamic exercise. Med Sci Sports Exerc 2002; 34 (12): 2091-6
210. Parkin JM, Carey MF, Zhao S, et al. Effect of ambient temperature on human skeletal muscle metabolism during fatiguing submaximal exercise. J Appl Physiol 1999; 86 (3): 902-8
211. Gleeson N, Eston R, Marginson V, et al. Effects of prior concentric training on eccentric exercise induced muscle damage. Br J Sports Med 2003; 37 (2): 119-25
212. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982; 14 (5): 377-81
213. Cain WS, Stevens JC. Constant-effort contractions related to the electromyogram. Med Sci Sports 1973; 5 (2): 121-7
214. Skinner JS, Hutsler R, Bergsteinova V, et al. The validity and reliability of a rating scale of perceived exertion. Med Sci Sports 1973; 5 (2): 94-6
215. Pandolf KB, Noble BJ. The effect of pedalling speed and resistance changes on perceived exertion for equivalent power outputs on the bicycle ergometer. Med Sci Sports 1973; 5 (2): 132-6
216. Halson SL, Bridge MW, Meeusen R, et al. Time course of performance changes and fatigue markers during intensified training in trained cyclists. J Appl Physiol 2002; 93 (3): 947-56
217. Ulmer HV. Concept of an extracellular regulation of muscular metabolic rate during heavy exercise in humans by psychophysiological feedback. Experientia 1996; 52: 416-20
218. Williamson JW, McColl R, Mathews D, et al. Hypnotic manipuhylation of effort sense during dynamic exercise: cardiovascular responses and brain activation. J Appl Physiol 2001; 90 (4): 1392-9
219. 2peak in highly trained cyclists. Can J Appl Physiol 2003; 28 (4): 605-15
220. Shave RE, Dawson E, Whyte G, et al. Effect of prolonged exercise in a hypoxic environment on cardiac function and cardiac troponin T. Br J Sports Med 2004; 38 (1): 86-91
221. Terakado S, Takeuchi T, Miura T, et al. Early occurrence of respiratory muscle deoxygenation assessed by near-infrared spectroscopy during leg exercise in patients with chronic heart failure. Jpn Circ J 1999; 63 (2): 97-103
222. Pfeifer CP, Musch TI, McAllister RM. Skeletal muscle oxidative capacity and exercise tolerance in rats with heart failure. Med Sci Sports Exerc 2001; 33 (4): 542-8
223. Durstine LJ, Painter P, Franklin BA, et al. Physical activity for the chronically ill and disabled. Sports Med 2000; 30 (3): 207-19
224. Ansley L, Schabort E, St Clair Gibson A, et al. Regulation of pacing strategies during successive 4km time trials. Med Sci Sports Exerc 2004; 36 (10): 1819-25