LC-ESI-MS metabolic profiling analysis of taxanes from the extracts of Taxus chinensis cell cultures

Yaoxue Xuebao

Volumn 40, Issue 8, 2005, Pages 734-739

  Zhao, Chun Fang ^a   Yu, Long Jiang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cell culture; ESI MS MS; LC MS; Metabolic profiling analysis; Taxanes; Taxus chinensis

Indexed keywords

ALKALOID; BACCATIN III; BRIDGED COMPOUND; PACLITAXEL; PLANT EXTRACT; TAXANE; TAXOID; TAXUSPINE F;

ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; ELECTROSPRAY MASS SPECTROMETRY; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; MEDICINAL PLANT; METHODOLOGY; MOLECULAR WEIGHT; TAXUS;

ALKALOIDS; BRIDGED COMPOUNDS; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PACLITAXEL; PLANT EXTRACTS; PLANTS, MEDICINAL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TAXOIDS; TAXUS;

EID: 26844470125     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Walker K, Croteau R. Taxol biosynthetic genes [J]. Phytochemistry, 2001, 58(1):1-7.
2. Yu LJ, Zhao CF. Advance in secondary metablic engineering of production for taxol and its related taxanes [J]. High Technol Lett, 2003, 13(1):106-110.
3. Yukimune Y, Tabata H, Higashi Y, et al. Methyljasmonate induced over production of paclitaxel and baccatin III in Taxus cell suspension cultures [J]. Nat Biotechnol, 1996, 14(9):1129-1132.
4. Abliz Z, Fang QC, Liang XT, et al. Study on fragmentation behavior of taxoids by tandem mass spectrometry [J]. Chin Sci Bull, 2000, 45(8): 688-698.
5. Eisenreich W, Menhard B, Hylands PJ, et al. Studies on the biosynthesis of taxol; the taxane carbon skeleton is not of mevalonoid origin [J]. Proc Natl Acad Sci USA, 1996, 93(13):6431-6436.
6. Yu LJ, Lan WZ. Separation, purification and identification of taxanenes in extract of Taxus chinensis leaves [J]. Chem Ind Forest Prod, 2002, 22 (3):45-48.
7. Wang CG, Wu JY, Mei XG. Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding [J]. Biotechnol Prog, 2001, 17(1):89-94.
8. Zhang ZQ, Wang YS, Tian GL. Seperation and purificaton of taxol with solid-phase extraction and reversed-phase chromatography [J]. Pharm Biothechnol, 2000, 7(3):157-160.
9. Baloglu E, Kingston DGI. The taxane diterpenoids [J]. J Nat Prod, 1999, 62(10):1448-1472.
10. Madhusudanan KP, Chattopadhyay SK, Tripathi V, et al. LC-ESI-MS analysis of taxoids from the bark of Taxus wallichiana [J]. Biomed Chromatogr, 2002, 16(5):343-355.
11. Madhusudanan KP, Chattopadhyay SK, Tripathi V, et al. MS/MS profiling of taxoids from the needles of Taxus wallichiana [J]. Phytochem Anal, 2002, 13(1):18-30.
12. Chang Y, Abliz Z, Li LJ, et al. Study on fragmentation behavior of 5/7/6-type taxoids by tandem mass spectrometry [J]. J Mass Spectrom, 2000, 35(10):1207-1214.
13. Li SH, Zhang HJ, Yao P, et al. Taxane diterpenoids from the bark of Taxus yunnanensis [J]. Phytochemistry, 2001, 58(2):369-374.
14. Wu YQ, Zhu WH, Hu Q, et al. HPLC determination of Sinenxans in Taxus cultures of Taxus spp [J]. Chin J Pharm Anal, 1998, 18(1):18-21.
15. Senilh V, Blechert S, Colin M, et al. Mise en evidence de nouveaux analogues du taxol extraits de Taxus baccata [J]. J Nat Prod, 1984, 47(1):131-137.
16. Tong XJ, Fang WS, Zhou JY, et al. Three new taxane diterpenoids from needles and stems of Taxus cuspidata [J]. J Nat Prod, 1995, 58(2):233-238.