Effect of Emulphor, an emulsifier, on the pharmacokinetics and hepatotoxicity of oral carbon tetrachloride in the rat

Fundamental and Applied Toxicology

Volumn 36, Issue 1, 1997, Pages 54-61

  Sanzgiri, U Y ^a,b   Bruckner, J V ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; EMULSIFYING AGENT; RICINOMACROGOL;

ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DOSE RESPONSE; GAS CHROMATOGRAPHY; LIVER TOXICITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SOLUBILIZATION;

EID: 26844454204     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1997.2290     Document Type: Article

References (26)

1. 3 or TCE singly and in combination in the rat. Fundam. Appl. Toxicol. 14, 477-490.
2. Brown, B. L., Allis, J. W., Simmons, J. E., and House, D. E. (1995). Fasting for less than 24 h induces cytochrome P450 and 2 B1/2 activities in rats. Toxicol. Lett. 81, 39-44.
3. Bull, R. J., Brown, J. M., Meirhenry, E. A., Jorgenson, T. A., Robinson, M., and Stober, J. A. (1986). Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: Implications for chloroform carcinogenesis. Environ. Health Perspect. 69, 49-58.
4. Condie, L. W., Laurie, R. D., Mills, T., Robinson, M., and Bercz, J. P. (1986). Effect of gavage vehicle on hepatotoxicity of carbon tetrachloride in CD-mice: Corn oil versus Tween-60 aqueous emulsion. Fundam. Appl. Toxicol. 7, 199-206.
5. Elworthy, P. H., and Treon, J. F. (1967). Physiological activity of nonionic surfactants. In Nonionic Surfactants (M. J. Shick, Ed.), Chap. 28, pp. 923-970. Decker, New York.
6. Fox, J. L., and Lamson, M. L. (1986). RSTRIP User Handbook. Micromath, Inc., Salt Lake City.
7. Gerlach, U., and Hiby, W. (1974). Sorbitol dehydrogenase. In Methods in Enzymatic Analysis (H. O. Bergmeyer, Ed.), Vol. II, pp. 569-573. Academic Press, New York.
8. Gibaldi, M., and Feldman, S. (1970). Mechanisms of surfactant effects on drug absorption. J. Pharm. Sci. 59, 579-589.
9. Jorgenson, T. A., Meirhenry, E. F., Rushbrook, C. J., Bull, R. J., and Robinson, M. (1985). Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice. Fundam. Appl. Toxicol 5, 760-769.
10. Kim, H. J., Odend'hal, S., and Bruckner, J. V. (1990a). Effect of oral dosing vehicles on the acute hepatotoxicity of carbon tetrachloride in rats. Toxicol. Appl. Pharmacol. 102, 34-49.
11. Kim, H. J., Bruckner, J. V., Dallas, C. E., and Gallo, J. M. (1990b). Effect of dosing vehicles on the pharmacokinetics of orally administered carbon tetrachloride in rats. Toxicol. Appl. Pharmacol. 102, 50-60.
12. Klaunig, J. E., Ruch, R. J., and Pereira, M. A. (1986). Carcinogenicity of chlorinated methane and ethane compounds administered in drinking water to mice. Environ. Health Perspect. 69, 89-95.
13. Levine, R. R. (1975). Activation and inhibition of drug absorption. In International Encyclopedia of Pharmacology and Therapeutics, Chap. 5, Sect. 39B, pp. 297-333. Pergamon, Oxford.
14. Mattenheimer, H. (1971). Glutamate pyruvate transaminase (GPT) (alanineaminotransferase). In Clinical Enzymology, Principles and Applications, English ed., pp. 149-151. Ann Arbor Sci. Pub., Ann Arbor, MI.
15. Merrick, B. A., Robinson, M., and Condie, L. W. (1989). Differing hepatotoxicity and lethality after subacute trichloroethylene exposure in aqueous or corn oil gavage vehicles in B6C3F1 mice. J. Appl. Toxicol. 9, 15-21.
16. Nakajima, T., Koyama, Y., and Sato, A. (1982). Dietary modification of metabolism and toxicity of chemical substances - with special reference to carbohydrate. Biochem. Pharmacol. 31, 1005-1011.
17. NCI (National Cancer Institute). (1976). Carcinogenesis Bioassay of Chloroform, NTIS No. PB264018/AS. NCI, Washington, DC.
18. Nissim, J. A. (1960). Action of some surface-active compounds on the gastro-intestinal mucosa. Nature 187, 305-307.
19. 3 interaction study in isolated hepatocytes: Selection of a vehicle. Fundam. Appl. Toxicol. 13, 605-615.
20. 14C] carbon tetrachloride to exhaled, excreted and bound metabolites: Dose-response, time-course and pharmacokinetics. Biochem. Pharmacol 33, 3363-3374.
21. Rhone-Poulenc Co. (1988). Material Safety Data Sheet for Emulphor® EL-620. Cranbury, CT.
22. Sanders, V. M., Tucker, A. N., White, K. L., Jr., Kauffmann, B. M., Hallett, P., Carchman, R. A., Borzelleca, J. F., and Munson, A. E. (1982). Humoral and cell-mediated immune status in mice exposed to trichloroethylene in the drinking water. Toxicol. Appl. Pharmacol. 62, 358-368.
23. Sanzgiri, U. Y., Kim, H. J., Muralidhara, S., Dallas, C. E., and Bruckner, J. V. (1995). Effect of route and pattern of exposure on the pharmacokinetics and acute hepatotoxicity of carbon tetrachloride. Toxicol. Appl. Pharmacol. 134, 148-154.
24. Symons, J. M., Bellar, T. A., Carswell, J. K., Demarco, J., Kroop, K. L., Robeck, G. G., Seeger, D. R., Slocum, D. J., Smith, B. L., and Stevens, A. A. (1975). National organics reconnaissance survey for halogenated organics. J. Am. Water Works Assoc. 67, 634-647.
25. Tucker, A. N., Sanders, V. M., Barnes, D. W., Bradshaw, T. J., White, K. L., Jr., Sain, L. E., Borzelleca, J. F., and Munson, A. E. (1982). Toxicology of trichloroethylene in the mouse. Toxicol. Appl. Pharmacol. 62, 351-357.
26. Westrick, J. J., Mellow, J. W., and Thomas, R. F. (1984). The groundwater supply survey. J. Am. Water Works Assoc. 76, 52-59.