Pharmacological challenge with a serotonin ID agonist in alcohol dependence

BMC Psychiatry

Volumn 5, Issue , 2005, Pages

  Vythilingum, Bavanisha ^a   Hugo, Charmaine J ^a   Maritz, J Stefan ^b   Pienaar, Willie ^a   Stein, Dan J ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; SEROTONIN 1D AGONIST; SEROTONIN 1D RECEPTOR; SUMATRIPTAN; DIAGNOSTIC AGENT; SEROTONIN; SEROTONIN 1 AGONIST; SEROTONIN AGONIST;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DETOXIFICATION; DRINKING BEHAVIOR; DRUG MECHANISM; EMOTIONALITY; FEMALE; HUMAN; MALE; PATHOPHYSIOLOGY; PROVOCATION TEST; RATING SCALE; SEROTONINERGIC SYSTEM; ADDICTION; COMPARATIVE STUDY; DRUG EFFECT; EMOTION; PERSONALITY TEST; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; SYNAPTIC TRANSMISSION;

ALCOHOL DRINKING; ALCOHOLISM; BEHAVIOR, ADDICTIVE; CROSS-OVER STUDIES; EMOTIONS; FEMALE; HUMANS; MALE; PERSONALITY INVENTORY; PLACEBOS; QUESTIONNAIRES; RECEPTOR, SEROTONIN, 5-HT1D; SEROTONIN; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN RECEPTOR AGONISTS; SUMATRIPTAN; SYNAPTIC TRANSMISSION;

EID: 26844445609     PISSN: 1471244X     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-5-31     Document Type: Article

References (20)

1. LeMarquand D, Pihl RO, Benkelfat C: Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biological Psychiatry 1994, 36:326-227.
2. LeMarquand D, Pihl RO, Benkelfat C: Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biological psychiatry 1994, 36:395-421.
3. Verheul R, van den Brink W, Geerlings P: A three-pathway psychobiological model of craving for alcohol. Alcohol Alcohol 1999, 34(2):197-222.
4. Davidson C, Stamford JA: Evidence that 5-hydroxytryptamine release in rat dorsal raphe nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. Br J Pharmacol 1995, 114:1107-1109.
5. Benkelfat C, Murphy DL, Hill JL, George DT, Nutt D, Linnoila M: Ethanol-like properties of the serotonergic partial agonist m-chlorophenylpiperazine in chronic alcoholic patients. Archives of General Psychiatry 1991, 48:333.
6. Krystal JH, Webb E, Cooney N, Kranzler HR, Charney DS: Specificity of ethanol-like effects elicited by serotonergic and noradrenergic mechanisms. Archives of General Psychiatry 1994, 51:898-911.
7. Signs SA, Schechter MD: The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue. Pharmacol Biochem Behav 1988, 30:55-64.
8. Naranjo CA, Sullivan JT, Kadlec KE, Woodley-Remus DV, Kennedy G, Sellers EM: Differential effects of viqualine on alcohol intake and other consummatory behaviors. Clin Pharmacol Ther 1989, 46(3):301-9.
9. Naranjo CA, Kadlec KE, Sanhueza P, Woodley-Remus D, Sellers EM: Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers. Clin Pharmacol Ther 1990, 47(4):490-498.
10. Naranjo CA, Poulos CX, Bremner KE, Lanctot KL: Fluoxetine attenuates alcohol intake and desire to drink. Int Clin Psychopharmacol 1994, 9(3):163-72.
11. Naranjo CA, Poulos CX, Bremner KE, Lanctot KL: Citalopram decreases desirability, liking, and consumption of alcohol in alcohol-dependent drinkers. Clin Pharmacol Ther 1992, 51(6):729-39.
12. Vescovi PP, Coiro V: Persistence of defective serotonergic and GABAergic controls of growth hormone secretion in longterm abstinent alcoholics. Alcohol Alcohol 1997, 32(1):85-90.
13. Coiro V, Vescovi PP: Alcoholism abolishes the growth hormone response to sumatriptan administration in man. Metabolism 1995, 44(12):1577-80.
14. Novotny S, Hollander E, Phillips A, Allen A, Wasserman S, Iyengar R: Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders. Int J Neuropsychopharmacol 2004, 7(3):249-54.
15. Stein DJ, Van Heerden B, Wessels CJ, Van Kradenburg J, Warwick J, Wasserman HJ: Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive compulsive disorder: investigating the functional role of the serotonin auto-receptor. Prog Neuropsychopharmacol Biol Psychiatry 1999, 23(6):1079-1099.
16. Maisto SA, Connors GJ, Tucker JA, McCollam JB, Adesso VJ: Validation of the sensation scale: a measure of subjective physiological responses to alcohol. Behav Res Ther 1980, 18:37-43.
17. Hollander E, Stein DJ, DeCaria CM, Cohen L, Saoud JB, Skodol AE, Kellman D, Rosnick L, Oldham JM: Serotonergic sensitivity in borderline personality disorder: preliminary findings. American Journal of Psychiatry 1994, 151:277-280.
18. Bohn MJ, Krahn DD, Staehler BA: Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcoholism, Clinical and Experimental Research 1995, 19(3):600-6.
19. von Knorring A-L, Bohman M, von Knorring L, Oreland L: Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatr Scand 1985, 72:51-58.
20. George DT, Benkelfat C, Rawlings RR, Eckardt MJ, Phillips MJ, Nutt DJ, Wynne D, Murphy DL, Linnoila M: Behavioral and neuroendocrine responsesto m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects. Am J Psychiatry 1997, 154(1):81-7.