Combination of poly(L-lysine)-graft-dextran copolymer and 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA) modification synergistically stabilizes pyrimidine motif triplex at neutral pH

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 635-638

  Torigoe, Hidetaka ^a   Katayama, Takuma ^a   Obika, Satoshi ^b   Maruyama, Atushi ^c,d   Imanishi, Takeshi ^b  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRIDGED COMPOUND; CARBENE; COPOLYMER; DEXTRAN; NUCLEIC ACID; POLYLYSINE; PYRIMIDINE;

CHEMICAL MODIFICATION; CONFERENCE PAPER; MELTING POINT; MOLECULAR STABILITY; PH; ULTRAVIOLET SPECTROSCOPY;

AMINO ACID MOTIFS; DEXTRANS; DNA; HEAT; HYDROGEN-ION CONCENTRATION; LYSINE; MODELS, CHEMICAL; MOLECULAR BIOLOGY; NUCLEIC ACIDS; OLIGONUCLEOTIDES; POLYLYSINE; POLYMERS; PYRIMIDINES; TEMPERATURE; ULTRAVIOLET RAYS;

EID: 26644470125     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060113     Document Type: Conference Paper

References (7)

1. Soyfer, V.N.; Potaman, V.N. Triple-Helical Nucleic Acids; Springer-Verlag: New York, 1996.
2. Maruyama, A.; Katoh, M.; Ishihara, T.; Akaike, T. Comb-type polycations effectively stabilize DNA triplex. Bioconjug. Chem. 1997, 8, 3-6.
3. Ferdous, A.; Watanabe, H.; Akaike, T.; Maruyama, A. Poly (L-lysine)-graft-dextran copolymer: amazing effects on triplex stabilization under physiological pH and ionic conditions (in vitro). Nucleic Acids Res. 1998, 26, 3949-3954.
4. Torigoe, H.; Ferdous, A.; Watanabe, H.; Akaike, T.; Maruyama, A. Poly (L-lysine)- graft-dextran copolymer promotes pyrimidine motif triplex dNA formation at physiological pH: thermodynamic and kinetic studies. J. Biol. Chem. 1999, 274, 6161-6167.
5. 3-endo sugar puckering. Tetrahedron Lett. 1997, 38, 8735-8738.
6. Imanishi, T.; Obika, S. Syntheses and properties of novel conformationally restrained nucleoside analogues. J. Syn. Org. Chem. Jpn. 1999, 57, 969-980.
7. Torigoe, H.; Hari, Y.; Sekiguchi, M.; Obika, S.; Imanishi, T. 2′-O,4′-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH. J. Biol. Chem. 2001, 276, 2354-2360.