Determination of the molecular complexation constant between alprostadil and alpha-cyclodextrin by conductometry: Implications for a freeze-dried formulation

Journal of Pharmaceutical and Biomedical Analysis

Volumn 39, Issue 5, 2005, Pages 877-885

  Sheehy, Philip M ^a,c   Ramstad, Tore ^b  

^a KALAMAZOO COLLEGE   (United States)

^b PFIZER INC   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Binding constant; Complexation; Complexation constant; Conductometry; Freeze dried formulation

Indexed keywords

ALPHA CYCLODEXTRIN; EXCIPIENT; PROSTAGLANDIN E1;

AB INITIO CALCULATION; ARTICLE; BINDING AFFINITY; CAPILLARY ELECTROPHORESIS; COMPLEX FORMATION; CONDUCTANCE; CONDUCTOMETRY; DRUG DETERMINATION; DRUG FORMULATION; DRUG MIXTURE; DRUG STABILITY; FREEZE DRYING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; TITRIMETRY;

ALGORITHMS; ALPHA-CYCLODEXTRINS; ALPROSTADIL; BENZYL ALCOHOL; CHEMISTRY, PHARMACEUTICAL; CONDUCTOMETRY; FREEZE DRYING; KINETICS; LITHIUM; MAGNETIC RESONANCE SPECTROSCOPY; PLATELET AGGREGATION INHIBITORS; TEMPERATURE; THERMODYNAMICS;

EID: 26644464835     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.03.046     Document Type: Article

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