Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2′-deoxyguanosine

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 691-694

  Meier, C ^a   Grasl S ^a   Detmer, I ^b   Marx, A ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

C8 Arylamine Adducts; Chemical Carcinogenesis; DNA Damage; Mutations

Indexed keywords

AROMATIC AMINE; DEOXYGUANOSINE; DNA DIRECTED DNA POLYMERASE BETA; OLIGONUCLEOTIDE;

CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CONFERENCE PAPER; DNA DAMAGE; NUCLEOTIDE METABOLISM; SYNTHESIS;

AMINES; CARCINOGENS; CIRCULAR DICHROISM; DEOXYGUANOSINE; DNA ADDUCTS; DNA DAMAGE; DNA POLYMERASE BETA; DNA PRIMERS; MODELS, CHEMICAL; MOLECULAR BIOLOGY; MUTATION; OLIGONUCLEOTIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY; TEMPERATURE;

EID: 26644461954     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060267     Document Type: Conference Paper

References (4)

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2. Beland, F.A.; Kadlubar, F.F. Formation and persistence of arylamine DNA adducts in vivo. Environ. Health Perspect. 1985, 62, 19-36.
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4. Meier, C.; Gräsl, S. Highly efficient synthesis of a phosphoramidite building block of C8-deoxyguanosine adducts of aromatic amines. Synlett 2002, 5, 802-804.