Control of DNA conformation using 3′-S-phosphorothiolate-modified linkages

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 491-495

  Buckingham, Joanne ^a   Sabbagh, Ghalia ^a   Brazier, John ^a   Fisher, Julie ^b   Cosstick, Rick ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3' S PHOSPHOROTHIOLATE DERIVATIVE; DNA; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; OLIGODEOXYNUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

CHEMICAL BINDING; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; DNA CONFORMATION; GEOMETRY; MOLECULAR STABILITY; NUCLEOTIDE METABOLISM;

DNA; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; OLIGONUCLEOTIDES; PHOSPHORUS; RNA; TEMPERATURE; THERMODYNAMICS; THIONUCLEOTIDES;

EID: 26644460997     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200061776     Document Type: Conference Paper

References (5)

1. Beevers, A.P.G.; Fettes, K.J.; O'Neil, I.A.; Roberts, S.M.; Arnold, J.R.P.; Cosstick, R.; Fisher, J. Probing the effect of a 3′-S- phosphorothiolate link on the conformation of a DNA:RNA hybrid; implications for antisense drug design. Chem. Commun. 2002, 1458-1459.
2. 3-linked ribo- and deoxyribodinucleoside monophosphates. Magn. Reson. Chem. 1999, 37, 814-820.
3. Beevers, A.P.G.; Fettes, K.J.; Sabbagh, G.; Murad, F.K.; Arnold, J.R.P.; Cosstick, R.; Fisher, J. NMR and UV studies of 3′-S-phosphorothiolate modified DNA in a DNA:RNA hybrid dodecamer duplex; implications for antisense drug design. Org. Biomol. Chem. 2004, 2, 114-119.
4. Peterson, M.; Wengel, J. LNA: a versatile tool for therapeutics and genomics. Trends Biotechnol. 2003, 21(2), 74-81.
5. Sabbagh, G.; Fettes, K.J.; Gosian, R.; O'Neil, I.A.; Cosstick, R. Synthesis of phosphorothioamidites derived from 3′-thio-3′- deoxythymidine and 3′-thio-3-deoxycytidine and the automated synthesis of oligodeoxynucleotides containing a 3′-S-phosphorothiolate linkage. Nucleic Acids Res. 2004, 32(2), 495-501.