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Journal of Pharmaceutical and Biomedical Analysis

Volumn 39, Issue 5, 2005, Pages 1014-1020

In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide

(5) Lin, C Charles a Wong, Bradley K b Burgey, Christopher S a Gibson, Christopher R a Singh, Rominder a

a MERCK RESEARCH LABORATORIES (United States)

b AMGEN INC (United States)

Author keywords

Bioactivation; Cyanide; Metabolism

Indexed keywords

2 [6 CYANO 3 [(2,2 DIFLUORO 2 PYRIDIN 2 YLETHYL)AMINO] 2 OXOPYRAZIN 1(2H) YL] N [(3 FLUOROPYRIDIN 2 YL)METHYL]ACETAMIDE; CYANIDE; DRUG METABOLITE; PYRAZINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INCUBATION TIME; LIVER MICROSOME; OXIDATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELIABILITY; SPECTROPHOTOMETRY;

BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYANIDES; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; PYRIDINES; SPECTROMETRY, FLUORESCENCE; THROMBIN;

EID: 26644456441 PISSN: 07317085 EISSN: None Source Type: Journal
DOI: 10.1016/j.jpba.2005.05.028 Document Type: Article

Times cited : (12)

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