Phosphoramidate derivatives of 2′,5′-dideoxyadenosine as potential inhibitors of the EDHF phenomenon

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 553-555

  Gavazza, F ^a   Daverio, F ^a   Chaytor, A T ^b   Griffith, T M ^b   McGuigan, C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

EDHF Phenomenon; Phosphoramidate; Protide

Indexed keywords

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 2',5' DIDEOXYADENOSINE; ADENOSINE DEAMINASE; ADENYLATE CYCLASE; DIDANOSINE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ENZYME INHIBITOR; NUCLEOTIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

CONFERENCE PAPER; METABOLIC INHIBITION; NONHUMAN; RABBIT; REACTION ANALYSIS; SYNTHESIS;

ADENYLATE CYCLASE; AMIDES; ANIMALS; ARTERIES; CHEMISTRY, PHARMACEUTICAL; DIDEOXYADENOSINE; DRUG DESIGN; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NUCLEOTIDES; PHOSPHORIC ACIDS; RABBITS; VEINS;

ORYCTOLAGUS CUNICULUS;

EID: 26644455542     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200061809     Document Type: Conference Paper

References (5)

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2. Griffith, T.M.; Chaytor, A.T.; Edwards, D.H.; Daverio, F.; McGuigan, C. Enhanced inhibitory activity of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine. Br. J. Pharmacol. 2004, 142, 27-30.
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4. Laurent, D.; Ilana, S.; Jhonson, R.A. Synthesis of 2′,5′- dideoxy-adenosine-3′-monophosphate derivatives as allosteric inhibitors of adenylyl ciclase. Nucleosides Nucleotides 1995, 14(6), 1453-1460.
5. Curley, D.; McGuigan, C.; Devine, K.G.; O'Connor, T.J.; Jeffries, D.J.; Kinchington, D. Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity. Antivir. Res. 1990, 14, 345-356.