Synthesis of some 2′-fluoro-2′-deoxy-3′-C-ethynyl and 3′-C-vinyl-β-D-lyxofuranosyl nucleosides

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 713-715

  Moukha Chafiq, O ^a   Tiwari, K N ^a   Secrist III, J A ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 FLUORO 2 DEOXY BETA DEXTRO ARABINOFURANOSYL)CYTOSINE; 1 (2 FLUORO 2 DEOXY BETA DEXTRO ARABINOFURANOSYL)URACIL; CYTOSINE DERIVATIVE; NUCLEOSIDE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; ARABINONUCLEOTIDE; CYTOSINE; PYRIMIDINE NUCLEOSIDE;

CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODIFICATION; CONFERENCE PAPER; NUCLEOTIDE METABOLISM; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; ARTICLE; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; HUMAN; IN VITRO STUDY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL LINE;

ARABINONUCLEOTIDES; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CYTOSINE; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PYRIMIDINE NUCLEOSIDES;

EID: 26644452107     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060300     Document Type: Conference Paper

References (4)

1. Nair, V.; Jahnke, T.S. Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry. Antimicrob. Agents Chemother. 1995, 39, 1017-1029.
2. Montgomery, J.A.; Shortancy-Fowler, A.T.; Clayton, S.D.; Riordan, J.M.; Secrist, J.A., III. J. Med. Chem. 1992, 35, 397-401.
3. Hattori, H.; Tanaka, M.; Fukushima, M.; Sasaki, T.; Matsuda, A. Nucleosides and nucleotides. 158. 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl) cytosine, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil, and their nucleobase analogues as new potential multifunctional anti-tumor nucleosides with a broad spectrum of activity. J. Med. Chem. 1996, 39, 5005-5011.
4. Wilds, C.J.; Damha, M.J. 2′-deoxy-2′-fluoro-β-D- arabinonucleosides and oligonucleotides (2′F-ANA): synthesis and physicochemical studies. Nucleic Acids Res. 2000, 28, 3625-3635.