Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 881-885

  Silamkoti, A V ^a   Allan, P W ^a   Hassan, A E A ^a   Fowler, A T ^a   Sorscher, E J ^a   Parker, W B ^a   Secrist III, J A ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUOROADENINE PURINE NUCLEOSIDE DERIVATIVE; 6 METHYLPURINE NUCLEOSIDE DERIVATIVE; 9H PURINE 9 [5 O [2 (1H 1,2,4 TRIAZOL 1 YL)ETHYL] BETA RIBOFURANOSYL] 6 METHYL; IMIDAZOLE DERIVATIVE; NUCLEOSIDE DERIVATIVE; PRODRUG; PURINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; XYLOSE;

CANCER THERAPY; CONFERENCE PAPER; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUICIDE GENE THERAPY;

ADENINE; ANTINEOPLASTIC AGENTS; CARBON; ESCHERICHIA COLI; GENE THERAPY; HUMANS; MODELS, CHEMICAL; MUTATION; NEOPLASMS; NUCLEOSIDES; PRODRUGS; PURINE NUCLEOSIDES; PURINE-NUCLEOSIDE PHOSPHORYLASE; PURINES; SUBSTRATE SPECIFICITY; XYLOSE;

ESCHERICHIA COLI;

EID: 26644446490     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200059237     Document Type: Conference Paper

References (7)

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6. Smrz, M.; Farkas, J. Nucleic acid components and their analogues CXVII. Synthesis of 1-α-1-lyxofuranosylthymine. Coll. Czech. Chem. Commun. 1968, 33, 3803-3808.
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