A new approach to oligonucleotide N3′-→P5′ phosphoramidate building blocks

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 1063-1067

  Zielinska, Daria ^a   Pongracz, Krisztina ^a   Gryaznov, Sergei ^a  

^a GERON CORPORATION   (United States)

Author keywords

3 Aminonucleosides; Oligonucleotide Phosphoramidates

Indexed keywords

3' AMINO 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 3' AMINONUCLEOSIDE DERIVATIVE; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHORAMIDOUS ACID; UNCLASSIFIED DRUG;

CHEMICAL MODIFICATION; CONFERENCE PAPER; GLYCOSYLATION; REACTION ANALYSIS; SYNTHESIS;

BASE COMPOSITION; GUANOSINE; MODELS, CHEMICAL; MOLECULAR BIOLOGY; NITROGEN; NUCLEIC ACID CONFORMATION; NUCLEOSIDES; OLIGONUCLEOTIDES; PHOSPHORUS; THYMIDINE;

EID: 26644445730     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060068     Document Type: Conference Paper

References (3)

1. Herbert, B.-S.; Pongracz, K.; Shay, J.W.; Gryaznov, S.M. Oligonucleotide N3′-→P5′ phosphoramidates as efficient telomerase inhibitors. Oncogene 2002, 21, 638-642.
2. Ford, L.P.; Zou, Y.; Pongracz, K.; Gryaznov, S.M.; Shay, J.W.; Wright, W.E. Telomerase can inhibit the recombination based pathway of telomere maintenance in human cells. J. Biol. Chem. 2001, 276, 32198-32203.
3. Nelson, J.S.; Fearon, K.; Nguyen, M.Q.; McCurdy, S.N.; Frediani, J.F.; Foy, M.F.; Hirschbein, B.L. N3′-→P5′ oligodeoxyribonucleotide phosphoramidates: a new method of synthesis based on a phosphoramidite amine-exchange reaction. J. Org. Chem. 1997, 62, 7278-7287.