The impact of population heterogeneity on risk estimation in genetic counseling

BMC Medical Genetics

Volumn 5, Issue , 2004, Pages

  Liu, Wenlei ^a   Icitovic, Nikolina ^b   Shaffer, Michele L ^a   Chase, Gary A ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; GENETIC COUNSELING; GENETIC HETEROGENEITY; GENETIC RISK; HUMAN; LOGISTIC REGRESSION ANALYSIS; PREDICTION; RISK ASSESSMENT; SIMULATION; BIOLOGICAL MODEL; EPIDEMIOLOGY; GENETIC DISORDER; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; GENOTYPE; METHODOLOGY; REPRODUCIBILITY; RISK FACTOR; STANDARD; STATISTICAL MODEL;

BIAS (EPIDEMIOLOGY); GENETIC COUNSELING; GENETIC DISEASES, INBORN; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HUMANS; LOGISTIC MODELS; MODELS, GENETIC; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RISK FACTORS;

EID: 26444611535     PISSN: 14712350     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-5-18     Document Type: Article

References (13)

1. Brackenridge CJ, Teltscher B: Estimation of the age at onset of Huntington's disease from factors associated with the affected parent. J Med Genet 1975, 12:64-69.
2. Heimbuch RC, Matthysse S, Kidd KK: Estimating age-of-onset distributions for disorders with variable onset. Am J Hum Genet 1980, 32:564-574.
3. Ripatti S, Gatz M, Pedersen NL, Palmgren J: Three-state frailty model for age at onset of dementia and death in Swedish twins. Genet Epidemiol 2003, 24:139-149.
4. Paulson GW: Predictive tests in Huntington's disease. Res Publ Assoc Res Nerv Ment Dis 1976, 55:317-329.
5. Chakravarti A, Buetow KH: A strategy for using multiple linked markers for genetic counseling. Am J Hum Genet 1985, 37:984-997.
6. Chase GA, Markson LE, Brookmeyer R, Folstein SE: Covariate-dependent genetic counseling in Huntington's disease. J Neurogenet 1986, 3:215-223.
7. Gold LS, Gaylor DW, Slone TH: Comparison of cancer risk estimates based on a variety of risk assessment methodologies. Regul Toxicol Pharmacol 2003, 37:45-53.
8. Roth MP, Petersen GM, McElree C, Vadheim CM, Panish JF, Rotter JI: Familial empiric risk estimates of inflammatory bowel disease in Ashkenazi Jews. Gastroenterology 1989, 96:1016-1020.
9. Yoshida K, Tamai M, Kubota T, Kawame H, Amano N, Ikeda S, Fukushima Y: Analysis of 14 individuals who requested predictive genetic testing for hereditary neuromuscular diseases. Rinsho Shinkeigaku 2002, 42:113-117.
10. Begg C: On the use of familial aggregation in population-based case probands for calculating penetrance. J Natl Cancer Inst 2002, 94:1221-1226.
11. Lagakos SW: Effects of mismodelling and mismeasuring explanatory variables on tests of their association with a response variable. Stat Med 1988, 7:257-74.
12. Tosteson TD, Tsiatis AA: The asymptotic relative efficiency of score tests in a generalized linear model with surrogate covariates. Biometrika 1988, 75:507-514.
13. Begg MD, Lagakos S: On the consequences of model misspecification in logistic regression. Environ Health Perspect 1990, 87:69-75.