Validation of Haber's Rule (dose x time = constant) in rats and mice for monochloroacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin under conditions of kinetic steady state

Toxicology

Volumn 215, Issue 1-2, 2005, Pages 48-56

  Saghir, Shakil A ^a,c   Lebofsky, Margitta ^a   Pinson, David M ^a   Rozman, Karl K ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c DOW CHEMICAL COMPANY   (United States)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Haber's Rule; Kinetic steady state; Monochloroacetic acid

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CHLOROACETIC ACID;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCULATION; CHRONIC TOXICITY; COMA; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ELIMINATION; FEEDING; FEMALE; HALF LIFE TIME; KINETICS; MALE; MATHEMATICAL ANALYSIS; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; STEADY STATE; TOXICOKINETICS;

ACETIC ACIDS; ANIMALS; COMA; DIOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; KINETICS; MALE; MICE; MICE, INBRED STRAINS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TOXICITY TESTS;

ANIMALIA;

EID: 26444577813     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.06.009     Document Type: Article

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