A physiologically based toxicokinetic model of inhalation exposure to xylenes in Caucasian men

Regulatory Toxicology and Pharmacology

Volumn 43, Issue 2, 2005, Pages 203-214

  Adams, J C ^a,c   Dills, R L ^a   Morgan, M S ^a   Kalman, D A ^a   Pierce, C H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UW Eau Claire ^*  (United States)

^c ST PETERSBURG COLLEGE   (United States)

Author keywords

Biological monitoring; Blood; Human exposure; PBTK; Physiologically based toxicokinetic model; Xylene

Indexed keywords

DEUTERIUM; META XYLENE; ORTHO XYLENE; PARA XYLENE;

ADULT; AIRBORNE PARTICLE; ARTICLE; BIOLOGICAL MONITORING; CAUCASIAN; HUMAN; HUMAN EXPERIMENT; INHALATION; ISOMER; LIVER METABOLISM; MALE; PRIORITY JOURNAL; TOXICOKINETICS; WORKER;

ADIPOSE TISSUE; ADULT; AGING; BAYES THEOREM; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; INHALATION EXPOSURE; LUNG; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MODELS, STATISTICAL; PHARMACOKINETICS; PULMONARY ALVEOLI; STRUCTURE-ACTIVITY RELATIONSHIP; XYLENES;

EID: 26444573778     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2005.07.005     Document Type: Article

References (38)

1. Agency for Toxic Substances and Disease Registry, 1998. Evaluation of health effects of chemicals. V. xylenes: health effects, toxicokinetics, human exposure, and environmental fate. Toxicol. Ind. Health 14, 687-695.
2. American Conference of Governmental Industrial Hygienists, 1998. Threshold Limit Values for Chemical Substances and Physical Agents. Cincinnati, Ohio.
3. C.J. Baines, G.E. McKeown-Eyssen, N. Riley, D.E. Cole, L. Marshall, B. Loescher, and V. Jazmaji Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures Occup. Med. (Lond). 54 6 2004 408 418 Epub 2004 Sep 3
4. G.A. Csanady, A.L. Mendrala, R.J. Nolan, and J.G. Filser A physiologic pharmacokinetic model for styrene and styrene-7,8-oxide in mouse, rat and man Arch. Toxicol. 68 1994 143 157
5. K. Diem Documenta Geigy: Scientific Tables sixth ed. 1962 Geigy Pharmaceuticals Ardsley, New York
6. R.L. Dills, S.D. Kent, H. Checkoway, and D.A. Kalman Quantification of volatile solvents in the blood by static headspace analysis Talanta 38 1991 365 374
7. P.O. Droz, M.M. Wu, W.G. Cumberland, and M. Berode Variability in biological monitoring of solvent exposure. I. Development of a population physiological model Br. J. Ind. Med. 46 1989 447 460
8. J.V. Durnin, and J. Womersley Body fat assessed from total body density and its estimation from skin fold thickness: Measurements on 481 men and women aged 16 to 72 years Br. J. Nutr. 32 1974 77 97
9. M.L. Gargas, R.J. Burgess, D.E. Voisard, G.H. Cason, and M.E. Anderson Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues Toxicol. Appl. Pharamcol. 98 1989 87 99
10. D.M. Hetrick, A.M. Jarabek, and C.C. Travis Sensitivity analysis for physiologically based pharmacokinetic models J. Pharm. Biopharm. 19 1991 1 19
11. W.S. Holm, and M.B. Nordqvist Coexposure to toluene and p-xylene in man: uptake and elimination Br. J. Ind. Med. 42 1985 111 116
12. J. Jang, and P.O. Droz Ethnic differences in biological monitoring of several organic solvents II. A simulation study with a physiologically based pharmacokinetic model Int. Arch. Occup. Environ. Health 70 1997 41 50
13. G. Johanson Modeling of respiratory exchange of polar solvents Ann. Occup. Hyg. 35 1991 323 339
14. A. Koizumi Potential of physiologically based pharmacokinetic modeling for acetone Occup. Environ. Med. 52 1989 344 352
15. S. Kumagai, and I. Matsunaga Physiologically based pharmacokinetic model for acetone Occup. Environ. Med. 52 1995 344 352
16. J.M. Langman Xylene: its toxicity, measurement of exposure levels, absorption, metabolism and clearance Pathology 26 1994 301 309
17. L.K. Low, J.R. Meeks, and C.R. Mackerer Health effects of alkylbenzenes II. Xylenes Toxicol. Ind. Health 5 1 1989 85 105
18. M.J. Miller, and J.W. Edwards Possible preferential metabolism of xylene isomers following occupational exposure to mixed xylenes Int. Arch. Occup. Environ. Health 72 1999 89 97
19. J. Mordenti Man versus beast: pharmacokinetic scaling in mammals J. Pharm. Sci. 75 1986 1028 1040
20. M.S. Morgan, R.L. Dills, and D.A. Kalman Evaluation of stable isotope-labeled probes in the study of solvent pharmacokinetics in human subjects Int. Arch. Occup. Environ. Health 65 1993 S139 S142
21. T. Nakajima, and A. Sato Enhanced activity of liver drug-metabolizing enzymes for aromatic and chlorinated hydrocarbons following food deprivation Tox. Appl. Pharmacol. 50 1979 549 556
22. T. Nakajima, Y. Koyama, and A. Sato Dietary modification of metabolism and toxicity of chemical substances-with special reference to carbohydrate Biochem. Pharmacol. 31 1982 1005 1011
23. A.S. Nies, D.G. Shand, and G.R. Wilkinson Altered hepatic blood flow and drug disposition Clin. Pharm. 1 1976 135 155
24. L. Perbellini, P. Mozzo, F. Brugnone, and A. Zessee Physiologicomathematical model for studying human exposure to organic solvents: kinetics of blood/tissue n-hexane concentration and of 2, 5-hexadione in urine Br. J. Ind. Med. 43 1986 760 768
25. C.H. Pierce, R.L. Dills, M.S. Morgan, G.L. Nothstein, D.D. Shen, and D. Kalman Interindividual differences in 2H8-toluene toxicokinetics assessed by a semi-empirical physiologically based model Toxicol. Appl. Pharamcol. 139 1996 49 61
26. C.H. Pierce, R.L. Dills, G.W. Silvey, and D.A. Kalman Partition coefficients between human blood or adipose tissue and air for aromatic solvents Scand. J. Work Environ. Health 22 1996 112 118
27. C.H. Pierce, R.L. Dills, M.S. Morgan, P. Vicini, and D.A. Kalman Biological monitoring of controlled toluene exposure Int. Arch. Occup. Environ. Health 71 1998 433 444
28. A. Sato, T. Nakajima, and Y. Koyama Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons Toxicol. Appl. Pharmacol. 60 1981 8 15
29. A. Sato Toxicokinetics of benzene, toluene, and xylenes IARC Sci. Publ. 85 1988 47 64
30. A. Sato, K. Endoh, and T. Kaneko Individual differences in the kinetic behavior of trichloroethylene. A simulation study using a physiological pharmacokinetic model Sangyo Igaku. 31 1989 348 354
31. V. Sedivec, and J. Flek The absorption, metabolism, and excretion of xylenes in man Int. Arch. Occup. Environ. Health 37 1976 205 217
32. T.W. Simon Combining physiologically based pharmacokinetic modeling with Monte Carlo simulation to derive an acute inhalation guidance value for trichloroethylene Reg. Toxicol. Pharm. 26 1997 257 270
33. B.R. Smith, J.L. Plummer, R. Wolf, R.M. Philpot, and J.R. Bend o-Xylene metabolism by rabbit lung and liver and its relationship to the selective destruction of pulmonary cytochrome P-450 J. Pharm. Exp. Ther. 223 1982 736 742
34. R. Tardif, S. Lapare, G. Charest-Tardif, J. Brodeur, and K. Krishnan Physiologically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans Risk Anal. 15 1995 335 342
35. W. Tassaneeyakul, D.J. Birkett, J.W. Edwards, M.E. Veronese, W. Tassaneeyakul, R.H. Tukey, and J.O. Miners Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m-, and p-xylene J. Pharm. Exp. Ther. 276 1996 101 108
36. R. Thomas, P. Bigelow, T. Keefe, and R. Yang Variability in biological exposure indices using physiologically based pharmacokinetic modeling and Monte Carlo simulation Am. Ind. Hyg. Assoc. J. 57 1996 23 32
37. 8-toluene kinetics: an empirical Bayes estimation strategy Risk Anal. 19 1999 1127 1134
38. M. Wallen, S. Holm, and M.B. Nordqvist Coexposure to toluene and p-xylene in man: uptake and elimination Br. J. Ind. Med. 42 1985 111 116