메뉴 건너뛰기




Volumn 17, Issue 6, 2005, Pages 695-704

Peptide-loaded chimeric influenza virosomes for efficient in vivo induction of cytotoxic T cells

Author keywords

CTL induction; Hepatitis C vaccine

Indexed keywords

ASPARTYLLEUCYLMETHIONYLGLYCYLTYROSYLISOLEUCYLPROLYLLEUCYLVALINE; CD8 ANTIGEN; CHIMERIC IMMUNOPOTENTIATING RECONSTITUTED INFLUENZA VIROSOME; CHIMERIC PROTEIN; CORE PROTEIN; EPITOPE; GAMMA INTERFERON; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PHOSPHOLIPID; UNCLASSIFIED DRUG; VIROSOME; VIROSOME VACCINE; VIRUS GLYCOPROTEIN; HLA A ANTIGEN; HLA A*0201 ANTIGEN; HLA-A*0201 ANTIGEN; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; LIPOSOME;

EID: 26444556522     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh249     Document Type: Article
Times cited : (54)

References (51)
  • 1
    • 0016754576 scopus 로고
    • Formation of virosomes from influenza subunits and liposomes
    • Almeida, J. D., Edwards, D. C., Brand, C. M. and Heath, T. D. 1975. Formation of virosomes from influenza subunits and liposomes. Lancet 2:899.
    • (1975) Lancet , vol.2 , pp. 899
    • Almeida, J.D.1    Edwards, D.C.2    Brand, C.M.3    Heath, T.D.4
  • 2
    • 0027080416 scopus 로고
    • Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A
    • Gluck, R., Mischler, R., Brantschen, S., Just, M., Althaus, B. and Cryz, S. J., Jr. 1992. Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A. J. Clin. Invest. 90:2491.
    • (1992) J. Clin. Invest. , vol.90 , pp. 2491
    • Gluck, R.1    Mischler, R.2    Brantschen, S.3    Just, M.4    Althaus, B.5    Cryz Jr., S.J.6
  • 3
    • 0034014999 scopus 로고    scopus 로고
    • IRIV-adjuvanted hepatitis A vaccine: In vivo absorption and biophysical characterization
    • Zurbriggen, R., Novak-Hofer, I., Seelig, A. and Gluck, R. 2000. IRIV-adjuvanted hepatitis A vaccine: in vivo absorption and biophysical characterization. Prog. Lipid Res. 39:3.
    • (2000) Prog. Lipid Res. , vol.39 , pp. 3
    • Zurbriggen, R.1    Novak-Hofer, I.2    Seelig, A.3    Gluck, R.4
  • 4
    • 0037435877 scopus 로고    scopus 로고
    • Immunostimulating reconstituted influenza virosomes
    • Zurbriggen, R. 2003. Immunostimulating reconstituted influenza virosomes. Vaccine 21:921.
    • (2003) Vaccine , vol.21 , pp. 921
    • Zurbriggen, R.1
  • 5
    • 0012872151 scopus 로고    scopus 로고
    • Clinical and immunological studies with a new virosome-based hepatitis A vaccine
    • Federation of European Societies for Tropical Medicine and international Health Liverpool
    • Abrosch, F., Gluck, R. and Herzog, C. 1998. Clinical and immunological studies with a new virosome-based hepatitis A vaccine. In Proceeding of 2nd European Congress on Tropical Medicine, Federation of European Societies for Tropical Medicine and international Health Liverpool.
    • (1998) Proceeding of 2nd European Congress on Tropical Medicine
    • Abrosch, F.1    Gluck, R.2    Herzog, C.3
  • 6
    • 0030197965 scopus 로고    scopus 로고
    • Immunogenicity and adverse effects of inactivated virosome versus alum-adsorbed hepatitis A vaccine: A randomized controlled trial
    • Holzer, B. R., Hatz, C., Schmidt-Sissolak, D., Gluck, R., Althaus, B. and Egger, M. 1996. Immunogenicity and adverse effects of inactivated virosome versus alum-adsorbed hepatitis A vaccine: A randomized controlled trial. Vaccine 14:982.
    • (1996) Vaccine , vol.14 , pp. 982
    • Holzer, B.R.1    Hatz, C.2    Schmidt-Sissolak, D.3    Gluck, R.4    Althaus, B.5    Egger, M.6
  • 7
    • 0030812765 scopus 로고    scopus 로고
    • Immunogenicity of trivalent subunit versus virosome-formulated influenza vaccines in geriatric patients
    • Conne, P., Gauthey, L., Vernet, P. et al. 1997. Immunogenicity of trivalent subunit versus virosome-formulated influenza vaccines in geriatric patients. Vaccine 15:1675.
    • (1997) Vaccine , vol.15 , pp. 1675
    • Conne, P.1    Gauthey, L.2    Vernet, P.3
  • 8
    • 0030266157 scopus 로고    scopus 로고
    • A virosome vaccine antigen delivery system does not stimulate an antiphospholipid antibody response in humans
    • Cryz, S. J., Que, J. U. and Gluck, R. 1996. A virosome vaccine antigen delivery system does not stimulate an antiphospholipid antibody response in humans. Vaccine 14:1381.
    • (1996) Vaccine , vol.14 , pp. 1381
    • Cryz, S.J.1    Que, J.U.2    Gluck, R.3
  • 9
    • 0002638647 scopus 로고    scopus 로고
    • "Virosomes," a new liposome-like vaccine delivery system
    • Lasic, D. D. and Papahadjopoulos, D., eds, Elsevier, Amsterdam
    • Gluck, R. and Wegmann, A. 1998. "Virosomes," a new liposome-like vaccine delivery system. In Lasic, D. D. and Papahadjopoulos, D., eds, Medical Applications of Liposomes, p. 75. Elsevier, Amsterdam.
    • (1998) Medical Applications of Liposomes , pp. 75
    • Gluck, R.1    Wegmann, A.2
  • 10
    • 0019890491 scopus 로고
    • Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution
    • Wilson, I. A., Skehel, J. J. and Wiley, D. C. 1981. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 289:366.
    • (1981) Nature , vol.289 , pp. 366
    • Wilson, I.A.1    Skehel, J.J.2    Wiley, D.C.3
  • 11
    • 0016679968 scopus 로고
    • Activation of influenza A viruses by trypsin treatment
    • Klenk, H. D., Rott, R., Orlich, M. and Blodorn, J. 1975. Activation of influenza A viruses by trypsin treatment. Virology 68:426.
    • (1975) Virology , vol.68 , pp. 426
    • Klenk, H.D.1    Rott, R.2    Orlich, M.3    Blodorn, J.4
  • 12
    • 0030010945 scopus 로고    scopus 로고
    • 2 amino-terminal fusion peptide but not the coiled coil region
    • 2 amino-terminal fusion peptide but not the coiled coil region. J. Biol. Chem. 271:13417.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13417
    • Durrer, P.1    Galli, C.2    Hoenke, S.3
  • 14
    • 0019814443 scopus 로고
    • Infectious entry pathway of influenza virus in a canine kidney cell line
    • Matlin, K. S., Reggio, H., Helenius, A. and Simons, K. 1981. Infectious entry pathway of influenza virus in a canine kidney cell line. J. Cell Biol. 91:601.
    • (1981) J. Cell Biol. , vol.91 , pp. 601
    • Matlin, K.S.1    Reggio, H.2    Helenius, A.3    Simons, K.4
  • 15
    • 0025889027 scopus 로고
    • Differential stability of antigenic MHC class I-restricted synthetic peptides
    • Widmann, C., Maryanski, J. L., Romero, P. and Corradin, G. 1991. Differential stability of antigenic MHC class I-restricted synthetic peptides. J. Immunol. 147:3745.
    • (1991) J. Immunol. , vol.147 , pp. 3745
    • Widmann, C.1    Maryanski, J.L.2    Romero, P.3    Corradin, G.4
  • 16
    • 26444501951 scopus 로고    scopus 로고
    • Influenza Virus Hemagglutinin-mediated Membrane Fusion: Mechanistic Studies and Potential Applications
    • PhD Thesis. Federal Institute of Technology (ETH) Zürich, Zürich
    • Vadrucci, S. 2002. Influenza Virus Hemagglutinin-mediated Membrane Fusion: Mechanistic Studies and Potential Applications. PhD Thesis. Federal Institute of Technology (ETH) Zürich, Zürich (http://e-collection.ethbib.ethz.ch/cgi-bin/ show.pl?type=diss&nr=14765).
    • (2002)
    • Vadrucci, S.1
  • 17
    • 0035988241 scopus 로고    scopus 로고
    • In vitro studies of core peptide-bearing immunopotentiating reconstituted influenza virosomes as a non-live prototype vaccine against hepatitis C virus
    • Hunziker, I. P., Grabscheid, B., Zurbriggen, R., Gluck, R., Pichler, W. J. and Cerny, A. 2002. In vitro studies of core peptide-bearing immunopotentiating reconstituted influenza virosomes as a non-live prototype vaccine against hepatitis C virus. Int. Immunol. 14:615.
    • (2002) Int. Immunol. , vol.14 , pp. 615
    • Hunziker, I.P.1    Grabscheid, B.2    Zurbriggen, R.3    Gluck, R.4    Pichler, W.J.5    Cerny, A.6
  • 18
    • 0018170714 scopus 로고
    • Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus
    • Zinkernagel, R. M., Callahan, G. N., Klein, J. and Dennert, G. 1978. Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus. Nature 271:251.
    • (1978) Nature , vol.271 , pp. 251
    • Zinkernagel, R.M.1    Callahan, G.N.2    Klein, J.3    Dennert, G.4
  • 19
    • 0020077493 scopus 로고
    • Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
    • Keene, J. A. and Forman, J. 1982. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155:768.
    • (1982) J. Exp. Med. , vol.155 , pp. 768
    • Keene, J.A.1    Forman, J.2
  • 20
    • 0030848161 scopus 로고    scopus 로고
    • Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help
    • Bennett, S. R., Carbone, F. R., Karamalis, F., Miller, J. F. and Heath, W. R. 1997. Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J. Exp. Med. 186:65.
    • (1997) J. Exp. Med. , vol.186 , pp. 65
    • Bennett, S.R.1    Carbone, F.R.2    Karamalis, F.3    Miller, J.F.4    Heath, W.R.5
  • 21
    • 0033103127 scopus 로고    scopus 로고
    • CD4 T cells and their role in antitumor immune responses
    • Toes, R. E., Ossendorp, F., Offringa, R. and Melief, C. J. 1999. CD4 T cells and their role in antitumor immune responses. J. Exp. Med. 189:753.
    • (1999) J. Exp. Med. , vol.189 , pp. 753
    • Toes, R.E.1    Ossendorp, F.2    Offringa, R.3    Melief, C.J.4
  • 22
    • 0033959835 scopus 로고    scopus 로고
    • Induction of cytotoxic T lymphocyte activity by fusion-active peptide-containing virosomes
    • Arkema, A., Huckriede, A., Schoen, P., Wilschut, J. and Daemen, T. 2000. Induction of cytotoxic T lymphocyte activity by fusion-active peptide-containing virosomes. Vaccine 18:1327.
    • (2000) Vaccine , vol.18 , pp. 1327
    • Arkema, A.1    Huckriede, A.2    Schoen, P.3    Wilschut, J.4    Daemen, T.5
  • 24
    • 0034651580 scopus 로고    scopus 로고
    • Pathogenesis, natural history, treatment, and prevention of hepatitis C
    • Liang, T. J., Rehermann, B., Seeff, L. B. and Hoofnagle, J. H. 2000. Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann. Intern. Med. 132:296.
    • (2000) Ann. Intern. Med. , vol.132 , pp. 296
    • Liang, T.J.1    Rehermann, B.2    Seeff, L.B.3    Hoofnagle, J.H.4
  • 25
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Manns, M. P., McHutchison, J. G., Gordon, S. C. et al. 2001. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial. Lancet 358:958.
    • (2001) Lancet , vol.358 , pp. 958
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 26
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried, M. W., Shiffman, M. L., Reddy, K. R. et al. 2002. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 347:975.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 975
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 27
    • 0030892283 scopus 로고    scopus 로고
    • Cytotoxic T cells and viral hepatitis
    • Chisari, F. V. 1997. Cytotoxic T cells and viral hepatitis. J. Clin. Invest. 99:1472.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1472
    • Chisari, F.V.1
  • 28
    • 0033992625 scopus 로고    scopus 로고
    • Cell mediated immune response to the hepatitis C virus
    • Rehermann, B. and Chisari, F. V. 2000. Cell mediated immune response to the hepatitis C virus. Curr. Top. Microbiol. Immunol. 242:299.
    • (2000) Curr. Top. Microbiol. Immunol. , vol.242 , pp. 299
    • Rehermann, B.1    Chisari, F.V.2
  • 29
    • 0033119925 scopus 로고    scopus 로고
    • Analysis of a successful immune response against hepatitis C virus
    • Cooper, S., Erickson, A. L., Adams, E. J. et al. 1999. Analysis of a successful immune response against hepatitis C virus. Immunity 10:439.
    • (1999) Immunity , vol.10 , pp. 439
    • Cooper, S.1    Erickson, A.L.2    Adams, E.J.3
  • 30
    • 0034129951 scopus 로고    scopus 로고
    • Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C
    • Gruner, N. H., Gerlach, T. J., Jung, M. C. et al. 2000. Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C. J. Infect. Dis. 181:1528.
    • (2000) J. Infect. Dis. , vol.181 , pp. 1528
    • Gruner, N.H.1    Gerlach, T.J.2    Jung, M.C.3
  • 31
    • 0029198385 scopus 로고
    • Sequence analysis of the hepatitis C virus (HCV) core gene suggests the core protein as an appropriate target for HCV vaccine strategies
    • Hitomi, Y., McDonnell, W. M., Killeen, A. A. and Askari, F. K. 1995. Sequence analysis of the hepatitis C virus (HCV) core gene suggests the core protein as an appropriate target for HCV vaccine strategies. J. Viral Hepat. 2:235.
    • (1995) J. Viral Hepat. , vol.2 , pp. 235
    • Hitomi, Y.1    McDonnell, W.M.2    Killeen, A.A.3    Askari, F.K.4
  • 32
    • 0028835980 scopus 로고
    • Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif
    • Cerny, A., McHutchison, J. G., Pasquinelli, C. et al. 1995. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J. Clin. Invest. 95:521.
    • (1995) J. Clin. Invest. , vol.95 , pp. 521
    • Cerny, A.1    McHutchison, J.G.2    Pasquinelli, C.3
  • 33
    • 0035814134 scopus 로고    scopus 로고
    • Exploiting conformationally constrained peptidomimetics and an efficient human-compatible delivery system in synthetic vaccine design
    • Moreno, R., Jiang, L., Moehle, K. et al. 2001. Exploiting conformationally constrained peptidomimetics and an efficient human-compatible delivery system in synthetic vaccine design. Chembiochem 2:838.
    • (2001) Chembiochem. , vol.2 , pp. 838
    • Moreno, R.1    Jiang, L.2    Moehle, K.3
  • 35
    • 0030971268 scopus 로고    scopus 로고
    • HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice
    • Pascolo, S., Bervas, N., Ure, J. M., Smith, A. G., Lemonnier, F. A. and Perarnau, B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J. Exp. Med. 185:2043.
    • (1997) J. Exp. Med. , vol.185 , pp. 2043
    • Pascolo, S.1    Bervas, N.2    Ure, J.M.3    Smith, A.G.4    Lemonnier, F.A.5    Perarnau, B.6
  • 36
    • 0017137615 scopus 로고
    • The analysis of the monoclonal immune response to influenza virus. II. The antigenicity of the viral hemagglutinin
    • Gerhard, W. 1976. The analysis of the monoclonal immune response to influenza virus. II. The antigenicity of the viral hemagglutinin. J. Exp. Med. 144:985.
    • (1976) J. Exp. Med. , vol.144 , pp. 985
    • Gerhard, W.1
  • 37
    • 0015062851 scopus 로고
    • The polypeptide composition of influenza A viruses
    • Skehel, J. J. and Schild, G. C. 1971. The polypeptide composition of influenza A viruses. Virology 44:396.
    • (1971) Virology , vol.44 , pp. 396
    • Skehel, J.J.1    Schild, G.C.2
  • 38
    • 50549164858 scopus 로고
    • A rapid and sensitive sub-micro phosphorus determination
    • Böttcher, C. J. F., Van Gent, C. M. and Pries, C. 1961. A rapid and sensitive sub-micro phosphorus determination. Anal. Chim. Acta 24:203.
    • (1961) Anal. Chim. Acta , vol.24 , pp. 203
    • Böttcher, C.J.F.1    Van Gent, C.M.2    Pries, C.3
  • 39
    • 0022540150 scopus 로고
    • Quantitation of proteins by elution of Coomassie brilliant blue R from stained bands after sodium dodecyl sulfate-polyacrylamide gel electrophoresis
    • Ball, E. H. 1986. Quantitation of proteins by elution of Coomassie brilliant blue R from stained bands after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal. Biochem. 155:23.
    • (1986) Anal. Biochem. , vol.155 , pp. 23
    • Ball, E.H.1
  • 40
    • 0027317501 scopus 로고
    • Preparation, properties, and applications of reconstituted influenza virus envelopes (virosomes)
    • Bron, R., Ortiz, A., Dijkstra, J., Stegmann, T. and Wilschut, J. 1993. Preparation, properties, and applications of reconstituted influenza virus envelopes (virosomes). Methods Enzymol. 220:313.
    • (1993) Methods Enzymol. , vol.220 , pp. 313
    • Bron, R.1    Ortiz, A.2    Dijkstra, J.3    Stegmann, T.4    Wilschut, J.5
  • 41
    • 0019874707 scopus 로고
    • Use of resonance energy transfer to monitor membrane fusion
    • Struck, D. K., Hoekstra, D. and Pagano, R. E. 1981. Use of resonance energy transfer to monitor membrane fusion. Biochemistry 20:4093.
    • (1981) Biochemistry , vol.20 , pp. 4093
    • Struck, D.K.1    Hoekstra, D.2    Pagano, R.E.3
  • 42
    • 0023750880 scopus 로고
    • The use of fluorescence dequenching measurements to follow viral membrane fusion events
    • Loyter, A., Citovsky, V. and Blumenthal, R. 1988. The use of fluorescence dequenching measurements to follow viral membrane fusion events. Methods Biochem. Anal. 33:129.
    • (1988) Methods Biochem. Anal. , vol.33 , pp. 129
    • Loyter, A.1    Citovsky, V.2    Blumenthal, R.3
  • 44
    • 0038439355 scopus 로고    scopus 로고
    • Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs)
    • Gluck, R. 1999. Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs). Vaccine 17:1782.
    • (1999) Vaccine , vol.17 , pp. 1782
    • Gluck, R.1
  • 45
    • 0028864309 scopus 로고
    • Inhibition of influenza-induced membrane fusion by lysophosphatidylcholine
    • Gunther-Ausborn, S., Praetor, A. and Stegmann, T. 1995. Inhibition of influenza-induced membrane fusion by lysophosphatidylcholine. J. Biol. Chem. 270:29279.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29279
    • Gunther-Ausborn, S.1    Praetor, A.2    Stegmann, T.3
  • 46
    • 0029918812 scopus 로고    scopus 로고
    • Influenza-virus-liposome lipid mixing is leaky and largely insensitive to the material properties of the target membrane
    • Shangguan, T., Alford, D. and Bentz, J. 1996. Influenza-virus-liposome lipid mixing is leaky and largely insensitive to the material properties of the target membrane. Biochemistry 35:4956.
    • (1996) Biochemistry , vol.35 , pp. 4956
    • Shangguan, T.1    Alford, D.2    Bentz, J.3
  • 48
    • 0037081281 scopus 로고    scopus 로고
    • Targeting her-2/neu with antirat Neu virosomes for cancer therapy
    • Waelti, E., Wegmann, N., Schwaninger, R. et al. 2002. Targeting her-2/neu with antirat Neu virosomes for cancer therapy. Cancer Res. 62:437.
    • (2002) Cancer Res. , vol.62 , pp. 437
    • Waelti, E.1    Wegmann, N.2    Schwaninger, R.3
  • 49
    • 0035657650 scopus 로고    scopus 로고
    • Perspectives: Towards a peptide-based vaccine against hepatitis C virus
    • Hunziker, I. P., Zurbriggen, R., Glueck, R. et al. 2001. Perspectives: Towards a peptide-based vaccine against hepatitis C virus. Mol. Immunol. 38:475.
    • (2001) Mol. Immunol. , vol.38 , pp. 475
    • Hunziker, I.P.1    Zurbriggen, R.2    Glueck, R.3
  • 50
    • 0032531164 scopus 로고    scopus 로고
    • Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions
    • Sarobe, P., Pendleton, C. D., Akatsuka, T. et al. 1998. Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions. J. Clin. Invest. 102:1239.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1239
    • Sarobe, P.1    Pendleton, C.D.2    Akatsuka, T.3
  • 51
    • 1642452611 scopus 로고    scopus 로고
    • Influenza virosomes enhance class I restricted CTL induction through CD4+ T cell activation
    • Schumacher, R., Adamina, M., Zurbriggen, R. et al. 2004. Influenza virosomes enhance class I restricted CTL induction through CD4+ T cell activation. Vaccine 22:714.
    • (2004) Vaccine , vol.22 , pp. 714
    • Schumacher, R.1    Adamina, M.2    Zurbriggen, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.