A new furofuran lignan with antioxidant and antiseizure activities from the leaves of Petasites japonicus

Archives of Pharmacal Research

Volumn 28, Issue 9, 2005, Pages 1023-1026

  Min, Byung Sun ^a   Hui, Song Cui ^b   Lee, Hyeong Kyu ^a   Sok, Dai Eun ^b   Mee, Ree Kim ^b  

^a Catholic University of Daegu   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Antiseizure; DPPH radical scavenging; Furofuran lignan; Petasites japonicus; Petaslignolide A

Indexed keywords

EID: 26444543270     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977395     Document Type: Article

References (15)

1. Abe, F. and Yamauchi, T., 9α-Hydroxypinoresinol, 9α-hydroxymedioresinol and related lignans from Allamanda neriifolia. Phytochemistry, 27, 575-577 (1988).
2. Blois, M. S., Antioxidant determination by the use of a stable free radical. Nature, 181, 1199-1201 (1958).
3. Grossman, W. and Schmidramsl, H., An extract of Petasites hybridus is effective in the prophylaxis of migraine. Altern. Med. Rev., 6, 303-310 (2001).
4. Hou, C. C., Lin, S. J., Cheng, J. T., and Hsu, F. L., Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica. J. Nat. Prod., 66, 625-629 (2003).
5. Khan, K. A. and Shoeb, A., A lignan from Lonicera hypoleuca. Phytochemistry, 24, 628-630 (1985).
6. Lin, C. H., R. Li, C. Y., Kuoh, C. S., and Wu, T. S., Constituents from the leaves of Petasites formosanus and their antioxidant activity. Heterocycles, 60, 1881-1889 (2003).
7. Lin, C. H., Li, C. Y., and Wu, T. S., A novel phenylpropenoyl sulfonic acid and a new chlorophyll from the leaves of Petasites formosanus Kitamura. Chem. Pharm. Bull., 52, 1151-1152 (2004).
8. Min, B. S., Nakamura, N., Miyashiro, H., Kim, Y. H., and Hattori, M., Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activities by Constituents of Juglans mandshurica. Chem. Pharm. Bull., 48, 194-200 (2000).
9. Mizushina, Y., Kamisuki, S., Kasai, N., Ishidoh, T., Shimazaki, N., Takemura, M., Asahara, H., Linn, S., Yoshida, S., Koiwai, O., Sugawara, F., Yoshida, H., and Sakaguchi, K., Petasiphenol: A DNA polymerase l inhibitor. Biochemistry, 41, 14463-14471 (2002).
10. Mizushina, Y., Ishidoh, T., Kamisuki, S., Nakazawa, S., Takemura, M., Sugawara, F., Yoshida, H., and Sakaguchi, K., Flavonoid glycoside: A new inhibitor of eukaryotic DNA polymerase A and a new carrier for inhibitor-affinity chromatography. Biochem. Biophys. Res. Commun., 301, 480-487 (2003).
11. Mohanan, P. V. and Yamamoto, H. A., Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. Toxicol. Lett., 129, 99-105 (2002).
12. Sok, D.-E., Oh, S. H., Kim, Y. B., and Kim, M. R., Neuroprotective effect of rough aster butanol fraction against oxidative stress in the brain of mice challenged with kainic acid. J. Agric. Food Chem., 51, 4570-4575 (2003).
13. Wang, G. J., Shum, A. Y., Lin, Y. L., Liao, J. F., Wu, X. C., Ren, J., and Chen, C. F., Calcium channel blockade in vascular smooth muscle cells: major hypotensive mechanism of Spetasin, a hypotensive sesquiterpene from Petasites formosanus. J. Pharmacol. Exp. Therap., 297, 240-246 (2001).
14. Yeo, H., Chin, Y. W., Park, S. Y., and Kim, J., Lignans of Rosa multiflora roots. Arch. Pharm. Res., 27, 287-290 (2004).
15. Ziolo, G. and Samochowiec, L., Study on clinical properties and mechanisms of action of Petasites in bronchial asthma and chronic obstructive bronchitis. Pharm. Acta Helv., 72, 378-380 (1998).