Segmentation defects of the human axial skeleton without dysostoses or skeletal dysplasias

Fetal and Pediatric Pathology

Volumn 24, Issue 2, 2005, Pages 121-127

  Bates, Alan William ^a   Nale, Krsty ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Autopsy methods; Fetus radiography; Homeotic transformations; Ribs abnormalities; Vertebrae abnormalities

Indexed keywords

ARTICLE; AUTOPSY; AXIAL SEGMENTATION DEFECT; BONE DYSPLASIA; BONE RADIOGRAPHY; CLINICAL FEATURE; DIAGNOSTIC IMAGING; DYSOSTOSIS; FETUS; HUMAN; IMAGE ANALYSIS; MORPHOLOGY; PERINATAL PERIOD; PRIORITY JOURNAL; SKELETON MALFORMATION; THORAX OUTLET SYNDROME; VERTEBRA;

BONE DISEASES, DEVELOPMENTAL; DYSOSTOSES; FETUS; HUMANS; MUSCULOSKELETAL ABNORMALITIES; RIBS; SPINE;

EID: 26444519165     PISSN: 15513815     EISSN: 15513823     Source Type: Journal    
DOI: 10.1080/15227950500257333     Document Type: Article

References (14)

1. Horan GS, Wu K, Wolgemuth DJ, Behringer RR. Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice. Proc Natl Acad Sci USA 91:12644-12648, 1994.
2. Johnson DR, O'Higgins P. Is there a link between changes in the vertebral "box code" and the shape of vertebrae? A quantitative study of shape change in the cervical vertebral column of mice. J Theor Biol 183:89-93, 1996.
3. Krumlauf R. Evolution of the vertebrate Hox homeobox genes. Bioessays 14:245-252, 1992.
4. Gaunt SJ. Conservation in the Hox code during morphological evolution. Int J Dev Biol 38:549-552, 1994.
5. Burke AC, Nelson CE, Morgan BA, Tabin C. Hox genes and the evolution of vertebrate axial morphology. Development 121:333-346, 1995.
6. Cordes R, Schuster-Gossler K, Serth K, Gossler A. Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development 131:1221-1233, 2004.
7. Erken E, Ozer HT, Gulek B, Durgun B. The association between cervical rib and sacralization. Spine 27:1659-1664, 2002.
8. McNally E, Sandin B, Wilkins RA. The ossification of the costal element of the seventh cervical vertebra with particular reference to cervical ribs. J Anat 170:125-129, 1990.
9. Keeling JW, Kjaer I. Cervical ribs: useful marker of monosomy X in fetal hydrops. Pediatr Dev Pathol 2:119-123, 1999.
10. Condie BG, Capecchi MR. Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development 119:579-595, 1993.
11. Condie BG, Capecchi MR. Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature 370:304-307, 1994.
12. Davis AP, Capecchi MR. Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development 120:2187-2198, 1994.
13. Boulet AM, Capecchi MR. Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. Dev Biol 249:96-107, 2002.
14. Galis F. Why do almost all mammals have seven cervical vertebrae? Developmental constraints, Hox genes, and cancer. J Exp Zool 285:19-26, 1999.