Responses of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) to competitive endurance exercise in recreational athletes

International Journal of Sports Medicine

Volumn 26, Issue 8, 2005, Pages 645-650

  Vidotto, C ^a   Tschan, H ^b   Atamaniuk, J ^a   Pokan, R ^b   Bachl, N ^b   Muller M M ^a  

^a KAISER FRANZ JOSEF HOSPITAL   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Brain natriuretic peptide; Cardiac troponin I; Echocardiography; Exercise; Half marathon running; Myocardial damage

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BIOCHEMICAL MARKER; BRAIN NATRIURETIC PEPTIDE; UNCLASSIFIED DRUG;

ADAPTATION; ADULT; ARTICLE; ATHLETE; BLOOD SAMPLING; COMPETITION; ECHOCARDIOGRAPHY; ENDURANCE; EXERCISE; FEMALE; HEART EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE INJURY; HUMAN; HUMAN EXPERIMENT; LABORATORY TEST; MALE; MARATHON RUNNER; NORMAL HUMAN; QUANTITATIVE ANALYSIS; RECREATION; RUNNING; STRESS;

ADULT; EXERCISE; FEMALE; HUMANS; MALE; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; PHYSICAL ENDURANCE; TROPONIN I;

EID: 26444507193     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-830491     Document Type: Article

References (47)

1. ACC/AHA guideline for the clinical application of echocardiography: Executive summary. A report of the American College of Cardiology/American Heart Association. Task force on practice guidelines (Committee on clinical Application of Echocardiography). J Am Coll Cardiol 1997; 29: 862-879
2. Albert CM, Mittleman MA, Chae CU, Lee IM, Hennekens CH, Manson JE. Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med 2000; 343: 1355-1361
3. Apple FS, Murakami MM, Jesse RL, Levitt MA, Berger AK, Pearce LA, Collinson P. Near-bedside whole-blood cardiac troponin I assay for risk assessment of patients with acute coronary syndromes. Clin Chem 2002; 48: 1784-1787
4. Barletta G, Stefani L, Del Bene R, Fronzaroli C, Vecchiarino S, Lazzeri C, Fantini F, La Villa G. Effects of exercise on natriuretic peptides and cardiac function in man. Int J Cardiol 1998; 65: 217-225
5. Bartek J, Stejskal D, Lacnak B, Jurakova R. Application of determined NT-proBNP in physical standardized exercise. Biomed Papers 2003; 147: 71-75
6. Bay M, Kirk V, Parner J, Hassager C, Nielsen H, Krogsgaard K, Trawinski J, Boesgaard S, Aldershvile J. NT-proBNP: a new diagnostic screening tool to differentiate between patients with normal and reduced left ventricular systolic function. Heart 2003; 89: 150-154
7. Berger R, Huelsman M, Strecker K, Bojic A, Moser P, Stanek B, Pacher R. B-type natriuretic peptide predicts sudden death in patients with chronic heart failure. Circulation 2002; 105: 2392-2397
8. Bertrand ME, Simoons ML, Fox KA, Wallentin LC, Hamm CW, McFadden E, De Feyter PJ, Specchia F, Ruzyllo W. Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation; recommendations of the Task Force of the European Society of Cardiology. Eur Heart J 2000; 21: 1406-1432
9. Bonetti A, Tirelli F, Albertini R, Monica C, Monica M, Tredici G. Serum cardiac troponin T after repeated endurance exercise events. Int J Sports Med 1996; 17: 259-262
10. Chen Y, Serfass RC, Mackey-Bojack SM, Kelly KL, Titus JL, Apple FS. Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. J Appl Physiol 2000; 88: 1749-1755
11. Clerico A, Emdin M. Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: a review. Clin Chem 2004; 50: 33-50
12. Cleave P, Boswell TC, Speedy DB, Boswell DR. Plasma cardiac troponin concentrations after extreme exercise. Clin Chem 2001; 47: 608-610
13. Cowie MR, Struthers AD, Wood DA, Coats AJ, Thompson SG, Poole-Wilson PA, Sutton GC. Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet 1997; 350: 1349-1353
14. Davies E, Gawad Y, Takahashi M, Shi Q, Lam P, Styba G, Lau A, Heeschen C, Usategui M, Jackowski G. Analytical performance and clinical utility of a sensitive immunoassay for determination of human cardiac troponin I. Clin Biochem 1997; 30: 479-490
15. De Lemos JA, Mc Guire DK, Drazner MH. B-type natriuretic peptide in cardiovascular disease. Lancet 2003; 362: 316-322
16. Herrmann M, Scharhag J, Micica M, Urhausen A, Herrmann W, Kindermann W. Post-race kinetics of cardiac troponin T and I and N-terminal pro-brain natriuretic peptide in marathon runners. Clinical Chemistry 2003; 43: 209-213
17. Huang WS, Lee MS, Perng HW, Yang SP, Kuo SW, Chang HD. Circulating Brain natriuretic peptide values in healthy men before and after exercise. Metabolism 2002; 51: 1423-1426
18. Hunt PJ, Richards AM, Nicholls MG, Yandle TG, Doughty RN, Espiner EA. Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment. Clin Endocrinol 1997; 47: 287-296
19. Jensen KT, Carstens J, Ivarsen P, Pedersen EB. A new, fast and reliable radioimmunoassay of brain natriuretic peptide in human plasma. Reference values in healthy subjects and patients with different diseases. Scand J Clin Lab Invest 1997; 57: 529-540
20. Koller A. Exercise-induced increases in cardiac troponins and prothrombotic markers. Med Sci Sports Exerc 2003; 35: 444-448
21. Koller A, Summer P, Moser H. Regular exercise and subclinical myocardial injury during prolonged aerobic exercise (letter). JAMA 1999; 282: 1816
22. König D, Schumacher YO, Heinrich L, Schmid A, Berg A, Dickhuth HH. Myocardial stress after competitive exercise in professional road cyclists. Med Sci Sports Exerc 2003; 35: 1679-1683
23. La Gerche A, Boyle A, Wilson AM, Prior DL. No evidence of sustained myocardial injury following an Ironman distance triathlon. Int J Sports Med 2004; 25: 45-49
24. Laslett L, Eisenbud E, Lind R. Evidence of myocardial injury during prolonged strenuous exercise. Am J Cardiol 1996; 78: 488-490
25. Laslett L, Eisenbud E. Lack of detection of myocardial injury during competitive races of 100 miles lasting 18 to 30 hours. Am J Cardiol 1997; 80: 379-380
26. Loke I, Squire IB, Davies JE, Ng LL. Reference ranges for natriuretic peptides for diagnostic use are dependent on age, gender and heart rate. Eur J Heart Fail 2003; 5: 599-606
27. Lucia A, Serratosa L, Saborido A, Pardo J, Boraita A, Moran M, Bandres F, Megias A, Chicharro J. Short-term effects of marathon running: no evidence of cardiac dysfunction. Med Sci Sports Exerc 1999; 31: 1414-1421
28. Mair J, Schobersberger W, Koller A, Bialk P, Villiger B, Frey W, Puschendorfer B. Risk for exercise-induced myocardial injury for athletes performing prolonged strenuous endurance exercise (Letter). Am J Cardiol 1997; 80: 543-544
29. Maron BJ, Thompson PD, Puffer JC, McGrew CA, Strong WB, Douglas PS, Clark LT, Mitten MJ, Crawford MH, Atkins CL, Driscoll DJ, Epstein AE. Cardiovascular preparticipation screening of competitive athletes. A statement for health professionals from the Sudden Death Committee (clinical cardiology) and Congenital Cardiac Defects Committee (cardiovascular disease in the young), American Heart Association. Circulation 1996; 94: 850-856
30. McDonagh TA, Robb S, Murdoch DR, Morton JJ, Ford I, Morrison CE, Tunstall-Pedoe H, McMurray JJ, Dargie HJ. Biochemical detection of left-ventricular systolic dysfunction. Lancet 1998; 351: 9-13
31. McLean AS, Huang SJ, Nalos M, Tang B, Stewart DE. The confounding effects of age, gender, serum creatinine, and electrolyte concentrations on plasma B-type natriuretic peptide concentrations in critically ill patients. Crit Care Med 2003; 31: 2611-2618
32. McNairy M, Gardetto N, Clopton P, Garcia A, Krishnaswamy P, Kazanegra R, Ziegler M, Maisel AS. Stability of B-type natriuretic peptide levels during exercise in patients with congestive heart failure: Implications for outpatient monitoring with B-type natriuretic peptide. Am Heart J 2002; 143: 406-411
33. Mittleman MA, Maclure M, Tofler GH, Sherwood JB, Goldberg RJ, Muller JE. Triggering of acute myocardial infarction by heavy physical exertion. N Engl J Med 1993; 329: 1677-1683
34. Nadal-Ginard B, Kajstura J, Anversa P, Leri A. A matter of life and death: cardiac myocyte apoptosis and regeneration. J Clin Invest 2003; 111: 1457-1459
35. Neumayr G, Gaenzer H, Pfister R, Sturm W, Schwarzacher SP, Eibl G, Mitterbauer G, Hoertnagl H. Plasma levels of cardiac troponin I after prolonged strenuous endurance exercise. Am J Cardiol 2001; 87: 369-371
36. Niessner A, Ziegler S, Slany J, Billensteiner E, Woloszczuk W, Geyer G. Increases in plasma levels of atrial and brain natriuretic peptides after running a marathon: are their effects partly counterbalanced by adrenocortical steroids? Eur J Endocrinol 2003; 149: 555-559
37. Ohba H, Takada H, Musha H, Nagashima J, Mori N, Awaya T, Omiya K, Murayama M. Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men. Am Heart J 2001; 141: 751-758
38. Ottani F, Galvani M, Nicolini FA, Ferrini D, Pozzati A, Di Pasquale G, Jaffe AS. Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes. Am Heart J 2000; 140: 917-927
39. Redfield MM, Rodeheffer RJ, Jacobsen SJ, Mahoney DW, Bailey KR, Burnett JC Jr. Plasma brain natriuretic peptide concentration: impact of age and gender. J Am Coll Cardiol 2002; 40: 976-982
40. Rifai N, Douglas PS, O'Toole M, Rimm E, Ginsburg GS. Cardiac troponin T and I, echocardiographic wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. Am J Cardiol 1999; 83: 1085-1089
41. Shave R, Dawson E, Whyte G, George K, Ball D, Collinson P, Gaze D. The cardiospecificity of the third-generation cTnT assay after exercise-induced muscle damage. Med Sci Sports Exerc 2002; 34: 651-654
42. Siegel AJ, Lewandrowski EL, Chun KY, Sholar MB, Fischman AJ, Lewandrowski KB. Changes in cardiac markers including B-natriuretic peptide in runners after the Boston marathon. Am J Cardiol 2001; 88: 920-923
43. Steele IC, McDowell G, Moore A, Campbell NP, Shaw C, Buchanan KD, Nicholls DP. Responses of atrial natriuretic peptide and brain natriuretic peptide to exercise in patients with chronic heart failure and normal control subjects. Eur J Clin Invest 1997; 27: 270-276
44. Stein BC, Levin RI. Natriuretic peptides: physiology, therapeutic potential, and risk stratification in ischemic heart disease. Am Heart J 1998; 135: 914-923
45. Tanabe K, Yamamoto A, Suzuki N, Akashi Y, Seki A, Samejima H, Oya M, Murabayashi T, Nakayama M, Yokoyama Y, Osada N, Omiya K, Itoh H, Miyake F, Murayama M. Exercise-induced changes in plasma atrial natriuretic peptide and brain natriuretic peptide concentration in healthy subjects with chronic sleep deprivation. Jpn Circ J 1999; 63: 447-452
46. Willich SN, Lewis M, Lowel H, Arntz HR, Schubert F, Schroder R. Physical exertion as a trigger of acute myocardial infarction. Triggers and Mechanisms of Myocardial Infarction Study Group. N Engl J Med 1993; 329: 1684-1690
47. Yamazaki H, Senju Y, Kinoshita N, Katsukawa F, Onishi S. Plasma brain natriuretic peptide in athletes. Am J Cardiol 2000; 85: 1393-1394