Surfactant proteins in innate host defense of the lung

Biology of the Neonate

Volumn 88, Issue 3, 2005, Pages 175-180

  Whitsett, Jeffrey A ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Collectins; Lung infection; Pulmonary surfactant

Indexed keywords

COLLECTIN; SURFACTANT PROTEIN A; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; SURFACTANT PROTEIN D;

BACTERIUM; FUNGUS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; LUNG ALVEOLUS EPITHELIUM; LUNG INFECTION; LUNG INJURY; MACROPHAGE; OPSONIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; VIRUS;

ANIMALS; BACTERIAL INFECTIONS; HUMANS; LUNG DISEASES; LUNG DISEASES, FUNGAL; PULMONARY SURFACTANT-ASSOCIATED PROTEIN A; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; PULMONARY SURFACTANTS; VIRUS DISEASES;

BACTERIA (MICROORGANISMS);

EID: 26444504819     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087580     Document Type: Review

References (46)

1. McCormack FX, Whitsett JA: The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J Clin Invest 2002;109:707-712.
2. van de Wetering JK, van Golde LM, Batenburg JJ: Collectins: players of the innate immune system. Eur J Biochem 2004;271:1229-1249.
3. Hawgood S, Poulain FR: The pulmonary collectins and surfactant metabolism. Annu Rev Physiol 2001;63:495-519.
4. Hakansson K, Reid KB: Collectin structure: a review. Protein Sci 2000;9:1607-1617.
5. Hoover RR, Floros J: Organization of the human SP-A and SP-D loci at 10q22-q23. Physical and radiation hybrid mapping reveal gene order and orientation. Am J Respir Cell Mol Biol 1998;18:353-362.
6. Pryhuber GS, Hull WM, Fink I, McMahan MJ, Whitsett JA: Ontogeny of surfactant proteins A and B in human amniotic fluid as indices of fetal lung maturity. Pediatr Res 1991;30:597-605.
7. Merrill JD, Ballard RA, Cnaan A, Hibbs AM, Godinez RI, Godinez MH, Truog WE, Ballard PL: Dysfunction of pulmonary surfactant in chronically ventilated premature infants. Pediatr Res 2004;56:918-926.
8. Thomson MA, Yoder BA, Winter VT, Martin H, Catland D, Siler-Khodr TM, Coalson JJ: Treatment of immature baboons for 28 days with early nasal continuous positive airway pressure. Am J Respir Crit Care Med 2004;169:1054-1062.
9. Korfhagen TR, Bruno MD, Ross GF, Huelsman KM, Ikegami M, Jobe AH, Wert SE, Stripp BR, Morris RE, Glasser SW, Bachurski CJ, Iwamoto HS, Whitsett JA: Altered surfactant function and structure in SP-A gene targeted mice. Proc Natl Acad Sci USA 1996;93:9594-9599.
10. Ikegami M, Korfhagen TR, Whitsett JA, Bruno MD, Wert SE, Wada K, Jobe AH: Characteristics of surfactant from SP-A-deficient mice. Am J Physiol 1998;275:L247-L254.
11. LeVine AM, Bruno MD, Huelsman KM, Ross GF, Whitsett JA, Korfhagen TR: Surfactant protein-A deficient mice are susceptible to group B streptococcal infection. J Immunol 1997;158:4336-4340.
12. Harrod KS, Trapnell BC, Otake K, Korfhagen TR, Whitsett JA: SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection. Am J Physiol 1999;277:L580-L588.
13. Li G, Siddiqui J, Hendry M, Akiyama J, Edmondson J, Brown C, Allen L, Levitt S, Poulain F, Hawgood S: Surfactant protein-A-deficient mice display an exaggerated early inflammatory response to a β-resistant strain of influenza A virus. Am J Respir Cell Mol Biol 2002;26:277-282.
14. Crouch EC, Whitsett JA: Diverse roles of lung collectins in pulmonary innate immunity; in Ezekowitz RAB, Hoffman JA (eds): Innate Immunity. Totowa, Humana Press, 2003, chapt 12.
15. Persson A, Chang D, Rust K, Moxley M, Longmore W, Crouch E: Purification and biochemical characterization of CP4 (SP-D), a collagenous surfactant-associated protein. Biochemistry 1989;28:6361-6367.
16. Madsen J, Kliem A, Tornøe I, Skjødt K, Koch C, Holmskov U: Localization of lung surfactant protein D on mucosal surfaces in human tissues. J Immunol 2000;164:5866-5870.
17. Stahlman MT, Gray ME, Hull WM, Whitsett JA: Immunolocalization of surfactant protein-D (SP-D) in human fetal, newborn, and adult tissues. J Histochem Cytochem 2002;50:651-660.
18. Korfhagen TR, Sheftelyevich V, Burhans MS, Bruno MD, Ross GF, Wert SE, Stahlman MT, Jobe AH, Ikegami M, Whitsett JA, Fisher JH: Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J Biol Chem 1998;273:28438-28443.
19. Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S: Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci USA 1998;95:11869-11874.
20. Zhang L, Ikegami M, Dey CR, Korfhagen TR, Whitsett JA: Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo. J Biol Chem 2002;277:38709-38713.
21. Wert SE, Yoshida M, LeVine AM, Ikegami M, Jones T, Ross GF, Fisher JH, Korfhagen TR, Whitsett JA: Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci USA 2000;97:5972-5977.
22. Ikegami M, Na C-L, Korfhagen TR, Whitsett JA: Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells. Am J Physiol Lung Cell Mol Physiol 2005;288:L552-L561.
23. Yoshida M, Korfhagen TR, Whitsett JA: Surfactant protein D regulates NF-κB and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J Immunol 2001;166:7514-7519.
24. LeVine AM, Whitsett JA, Hartshorn KL, Crouch EC, Korfhagen TR: Surfactant protein-D enhances clearance of influenza A virus from the lung in vivo. J Immunol 2001;167:5868-5873.
25. LeVine AM, Elliott J, Whitsett JA, Srikiatkhachorn A, Crouch E, DeSilva N, Korfhagen T: Surfactant protein-D enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. Am J Respir Cell Mol Biol 2004;31:193-199.
26. Hartshorn KL, White MR, Shepherd V, Reid K, Jensenius JC, Crouch EC: Mechanisms of anti-influenza activity of surfactant proteins A and D: Comparison with serum collectins. Am J Physiol 1997;273:L1156-L1166.
27. Wu H, Kuzmenko A, Wan S, Schaffer L, Weiss A, Fisher JH, Kim KS, McCormack FX: Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. J Clin Invest 2003;111:1589-1602.
28. Whitsett JA, Weaver TE: Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 2002;347:2141-2148.
29. Weaver TE, Conkright JJ: Function of surfactant proteins B and C. Annu Rev Physiol 2001;63:555-578.
30. Whitsett JA, Ohning BL, Ross G, Meuth J, Weaver T, Holm BA, Shapiro DL, Notter RH: Hydrophobic surfactant-associated protein in whole lung surfactant and its importance for biophysical activity in lung surfactant extracts used for replacement therapy. Pediatr Res 1986;20:460-467.
31. Nogee LM, Garnier G, Dietz HC, Singer L, Murphy AM, deMello DE, Colten HR: A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds. J Clin Invest 1994;93:1860-1863.
32. Clark JC, Wert SE, Bachurski CJ, Stahlman MT, Stripp BR, Weaver TE, Whitsett JA: Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci USA 1995;92:7794-7798.
33. Glasser SW, Detmer EA, Ikegami M, Na C-L, Stahlman MT, Whitsett JA: Pneumonitis and emphysema in sp-C gene targeted mice. J Biol Chem 2003;278:14291-14298.
34. Nogee LM, Dunbar AE, Wert SE, Askin F, Hamvas A, Whitsett JA: A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 2001;344:573-579.
35. Gregory TJ, Longmore WJ, Moxley MA, Whitsett JA, Reed CR, Fowler AA, Hudson LD, Maunder RJ, Crim C, Hyers TM: Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J Clin Invest 1991;88:1976-1981.
36. Greene KE, Wright JR, Steinberg KP, Ruzinski JT, Caldwell E, Wong WB, Hull W, Whitsett JA, Akino T, Kuroki Y, Nagae H, Hudson LD, Martin TR: Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med 1999;160:1843-1850.
37. Nogee LM, Wert SE, Profitt SA, Hull WM, Whitsett JA: Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency. Am J Respir Crit Care Med 2000;161:973-981.
38. Dunbar AE, Wert SE, Ikegami M, Whitsett JA, Hamvas A, White FV, Piedboeuf B, Jobin C, Guttentag S, Nogee LM: Prolonged survival in hereditary surfactant protein B (SP-B) deficiency associated with a novel splicing mutation. Pediatr Res 2000;48:275-282.
39. Cameron HS, Somaschini M, Carrera P, Hamvas A, Whitsett JA, Wert SE, Deutsch G Nogee LM: A common mutation in the surfactant protein C gene associated with lung disease. J Pediatr 2005;146:370-375.
40. Thomas AQ, Lane K, Phillips J III, Prince M, Markin C, Speer M, Schwartz DA, Gaddipati R, Marney A, Johnson J, Roberts R, Haines J, Stahlman M, Loyd JE: Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med 2002;165:1322-1328.
41. Kaser MR, Skouteris GG: Inhibition of bacterial growth by synthetic SP-B1-78 peptides. Peptides 1997;18:1441-1444.
42. Akinbi HT, Bhatt H, Hull WM, Weaver TE: Altered surfactant protein B levels in transgenic mice do not affect clearance of bacteria from the lungs. Pediatr Res 1999;46:530-534.
43. Augusto L, Le Blay K, Auger G, Blanot D, Chaby R: Interaction of bacterial lipopolysaccharide with mouse surfactant protein C inserted into lipid vesicles. Am J Physiol Lung Cell Mol Physiol 2001;281:L776-L785.
44. Tokieda K, Iwamoto HS, Bachurski C, Wert SE, Hull WM, Ikeda K, Whitsett JA: Surfactant protein-B-deficient mice are susceptible to hyperoxic lung injury. Am J Respir Cell Mol Biol 1999;21:463-472.
45. Glasser SW, Burhans MS, Korfhagen TR, Na CL, Sly PD, Ross GF, Ikegami M, Whitsett JA: Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc Natl Acad Sci USA 2001;98:6366-6371.
46. Glasser SW, Maxfield MD, Richardson TR, Whitsett JA, Baatz JE, Wert SE, Senft AP, Korhagen TR: SP-C deficient mice are susceptible to P. aeruginosa infection. Proc Am Thorac Soc 2005;2:A454.