Synthesis and biological evaluation of new 1, 4-dihydropyridines as antihypertensives agents in rats

Iranian Journal of Pharmaceutical Research

Volumn 2, Issue 1, 2003, Pages 43-46

  Jorjani, Masoumeh ^a   Rastegar, Hossein ^a   Roshanzamir, Farshad ^a   Varmazyari, Mehdí ^c   Abdollahi, Mohammad ^c   Zarghi, Afshin ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1, 4 dihydropyridines; Antihypertensive activity; Rat

Indexed keywords

EID: 26444484417     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: 10.22037/IJPR.2010.34     Document Type: Article

References (14)

1. Triggle DG. Biochemical and Pharmacologic Differences Among Calcium Channal Antagonists:Clinical Implication. In: Epstein M. (ed) Calcium Antagonists in Clinical Medicine. Hanley & Belfus, Philadelphia (1992) 1- 29
2. Wenzel RR, Bruck H, -Noll G, Daul AE and Philip T. Antihypertensive Drugs and the Sympathetic Nervous System. J. Cardiovasc. Pharmacol. (2000) 35: S43-52
3. Denner JM, Zhang LH and Rapoport H. An effective Chirospecific Synthesis of (+)Pilocarpine from LAspartic Acid. J. Org. Chem. (1993) 58: 1159-1166
4. Opie LH and Yusuf S. Current Status Safty and Efficacy of Calcium Channel Blockers in Cardiovascular Diseases: a Critical Analysis Based on 100 Studies. Prog. Cardiovasc. Dis. (2000) 43:171-96
5. Arrowsmith JE, CampbellS F, Cross PE, Stubbs JK, Burges RA, Gardiner DG and Blackburn KJ. Longacting Dihydropyridine Calcium Antagonists. 1, 2-Alkoxymethy Derivatives Iincorporating Basic Substituents. J. Med. Chem. (1986) 29: 1696- 1702
6. Baldwin JJ and Sweet CS. Antihypertensive Agents. Ann. Rept. Med. Chem. (1988) 23: 59- 68
7. Shafiee A, Miri A, Dehpour AR and Soleymani F. Synthesis and Calcium-channel Antagonist Activity of Nifedipine Analouges Containing Nitroimidazolyl Substituent in Guinea-pig Ileal Smooth Muscle. J. Pharm. Sci. (1996) 2: 541-543
8. Freedman DD and Waters DD. Second Generation Dihydropyridine Calcium Antagonists. Greater Vascular Selectivity and some Unique Applications. Drugs (1987) 34: 578-598
9. Cattaruzza M, Wachter R, Wagner AH and Hecker M. Modulation by Dihydropyridine-type Calcium Channel Antagonists of Cytokine-inducible Gene Experssion in Vascular Smooth Muscle Cells. Br. J. Pharmacol. (2000) 129:1155-62
10. Vo D, Matowe WC, Ramesh M, Iqbal N, Wolowyk M W, Hqwlett S E and Knaus EE. Syntheses, Calcium Channel Agonist-antagonist Modulation Activities and Voltage-clamp Studies of Isopropyl 1, 4- dihydro-2, 6-dimethyl-3-nitro-4-pyridylpyridine-5-carboxylate Racemates and Enantiomers. J. Med. Chem. (1995) 38: 2851- 2859
11. Hantzsch A. Ueber die Synthese Pyridinartiger Verbindungen aus Acetessigather und Aldehydammoniak. Justus Liebigs. Ann.Chem. (1882) 215: 1-82
12. Pfeffer JM, Pfeffer MA and Frohlich ED. Validity of an Indirect Tail-caff Method for Determining Systolic Arterial Pressure in Unanesthetized Normotensive and Spontaneously Hypertensive Rats. J. Lab. Clin. (1971) 78: 957-962
13. Vogel HG and Vogel WH. (Eds) Drug Discovery and Evaluation, Pharmacological Assay. Springerverlay, Berlin (1997) 47-49
14. Dunnett CW. Pairwise Multiple Comparisons in the Homogeneous Variance, Unequal Sample-size Case. J. Am. Statist. Assoc. (1980) 75: 789-795