Glucose-lipid ratio is a determinant of nitrogen balance during total parenteral nutrition in critically ill patients: A prospective, randomized, multicenter blind trial with an intention-to-treat analysis

Intensive Care Medicine

Volumn 31, Issue 10, 2005, Pages 1394-1400

  Bouletreau P ^a   Chassard, D ^a   Allaouchiche, B ^a   Dumont, J C ^b   Auboyer, C ^c   Bertin Maghit, M ^a   Bricard, H ^d   Ecochard, R ^e   Rangaraj, J ^f   Chambrier, C ^a   Schneid, C ^g   Cynober, L ^g  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE   (France)

^c UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^d CAEN UNIVERSITY HOSPITAL   (France)

^e HOSPICES CIVILS DE LYON   (France)

^f Lab Fresenius   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Critically ill patients; Glucose lipid ratio; Glycemic control; Nitrogen balance; Protein sparing

Indexed keywords

3 METHYLHISTIDINE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; LIPID; LIVER ENZYME; NITROGEN; PREALBUMIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; INTENSIVE CARE; MALE; NITROGEN BALANCE; RANDOMIZED CONTROLLED TRIAL; TOTAL PARENTERAL NUTRITION; URINALYSIS;

CRITICAL CARE; DIETARY FATS; FEMALE; GLUCOSE; HUMANS; MALE; MIDDLE AGED; NITROGEN; PARENTERAL NUTRITION, TOTAL; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD;

EID: 26444466174     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-005-2771-5     Document Type: Article

References (39)

1. Brennan MF, Fitzpatrick GF, Cohen KH, Moore FD (1975) Glycerol: major contributor to the short-term protein sparing effect of fat emulsions in normal mal. Ann Surg 182:386-394
2. Jeejeebhoy KN, Andersson GH, Nakooda AF, Greenberg GR, Sanderson I, Marliss EB (1976) Metabolic studies in total parenteral nutrition with lipid in man. Comparison with glucose. J Clin Lab Invest 57:25-136
3. Van Itallie TB, Moore FD, Geyer RP (1954) Will fat emulsions given intravenously promote protein synthesis? Metabolic studies on normal subjects and surgical patients. Surgery 36:720-731
4. Wilmore DW, Moylan JA, Helmkamp GM, Pruitt BA (1973) Clinical evaluation of a 10% intravenous fat emulsion for parenteral nutrition in thermally injury patients. Ann Surg 178:503-513
5. Iapichino G, Radrizzani D, Solca M, Pesenti A, Gattinoni L, Ferro A, Leoni L, Langar M, Vesconi S, Damia G (1994) The main determinants of nitrogen balance during parenteral nutrition in critically ill injured patients. Intensive Care Med 10:251-254
6. Battistella FD, Wildergren JT, Anderson JT, Siepler JK, Weber JC, MacColl K (1997) A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma 43:52-58
7. Hart DW, Wolf SE, Zhang XJ, Chinkes DL, Buffalo MC, Matin SI, DebRoy MA, Wolfe RR, Herndon DN (2001) Efficacy of a high-carbohydrate diet in catabolic illness. Crit Care Med 29:318-1324
8. Tappy L, Schwarz JM, Schneitez P, Cayeux C, Revelly JP, Fagerquist CK, Jequier E, Chiolero R (1998) Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. Crit Care Med 26:860-867
9. Garrel DR, Razi M, Larivière F, Jobin N, Naman N, Emptoz-Bonneton A, Pugeat MM (1995) Improved clinical status and length of ware with low-fat nutrition support in burn patients. JPEN J Parenter Enteral Nutr 19 482-491
10. Gogos CA, Kalfarentzos FE, Zoumbos NC (1990) Effect of different types of total parenteral nutrition on T-lymphocyte subpopulations and NK cells 1:2. Am J Clin Nutr 51:119-122
11. Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP (2002) Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med 30:2438-2442
12. Jensen GL, Mascioli EA, Seidner DL, Istfan NW, Donitch AM, Selleck K, Babayan VK, Blackburn GL, Bistrian BR (1990) Parenteral nutrition of long-and medium-chain triglycerides and reticuloendothelial system function in man. JPEN J Parenter Enteral Nutr 14:467-471
13. Van Den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345:1359-1367
14. Cardenas D, Blonde-Cynober F, Ziegler F, Cano N, Cynober L (2001) Should a single centre for the assay of biochemical markers of nutritional status be mandatory in multicentric trial? Clin Nutr 20:553-558
15. Cerra F, Blackburn G, Hirsch J (1987) The effect of stress level, amino acid formula and nitrogen dose on nitrogen retention in traumatic and septic stress. Ann Surg 205:282-287
16. Cerra FB (1987) Hypermetabolism, organ failure and metabolic support. Surgery 101:1-14
17. Clowes GHA, Heideman M, Lindberg B, Randall HD, Hirsch HF, Cha CJ, Martin H (1980) Effect of parenteral alimentation on amino acid metabolism in septic patient. Surgery 88:531-543
18. Frankenfield DC, Smith JS, Cooney RN (1997) Accelerated nitrogen loss after traumatic injury is not attenuated by achievement of energy balance. JPEN J Parenter Enteral Nutr 21:324-329
19. Greig PD, Elwyn DH, Askanazi J, Kinney JM (1987) Parenteral nutrition in septic patients: effects of increasing nitrogen intake. Am J Clin Nutr 46:1040-1047
20. Long JM III, Wilmore DW, Mason AD Jr, Pruitt BA Jr (1977) Effect of carbohydrate and fat intake on nitrogen excretion during total intravenous feeding. Ann Surg 185:417-422
21. Woolfson AM, Heatley RV, Allison SP (1979) Insulin to inhibit protein catabolism after injury. N Engl J Med 300:14-17
22. Baker JP, Detsky AS, Stewart S, Whitwell J, Marlisss EB, Jeejeebhoy KN (1984) Randomized trial of total parenteral nutrition in critically ill patients: metabolic effects of varying glucose-lipid ratios as the energy source. Gastroenterology 87:53-59
23. De Chalain TM, Michell WL, O'Keefe SJ, Ogden JM (1992) The effect of fuel source on amino acid metabolism in critically ill patients. J Surg Res 52:167-176
24. Nordenstrom J, Askanazi J, Elwyn DH, Martin P, Carpentier YA, Robin AP, Kinney JM (1983) Nitrogen balance during total parenteral nutrition: glucose vs. fat. Ann Surg 197:27-33
25. Paluzzi M, Meguid MM (1987) A prospective randomized study of the optimal source of nonprotein calories in total parenteral nutrition. Surgery 102:711-717
26. Shaw JH, Holdaway CM (1988) Protein-sparing effect of substrate infusion in surgical patients is governed by the clinical state, and not by the individual substrate infused. JPEN J Parenter Enteral Nutr 12:433-440
27. Chambrier C, Laville M, Rhzioul Berrada K, Odeon M, Boulétreau P, Beylot M (2000) Insulin sensitivity of glucose and fat metabolism in severe sepsis. Clin Sci (Lond) 99:321-328
28. Pierre EJ, Barrow RE, Harvkins HK, Nguyen TT, Sajurai Y, Desai M, Wolfe RR, Herdon DN (1998) Effects of insulin on wound healing. J Trauma 44:342-29.
29. Ferrando AA, Chinkes DL, Wolf SE, Matin S, Herndon DN, Wolfe RR (1999) A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. Ann Surg 229:11-18
30. Hinton P, Allison SP, Littlejohn S, Lloyd J (1971) Insulin and glucose to reduce catabolic response to injury in burned patients. Lancet 1:767-769
31. Sakurai Y, Aarsland A, Herndon DN, Chinkes DL, Pierre E, Nguyen TT, Patterson BW, Wolfe RR (1995) Stimulation of muscle protein synthesis by long-term insulin infusion in severely burned patients. Ann Surg 222:283-297
32. Gelfand RA, Barrett EJ (1987) Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J Clin Invest 80:1-6
33. Jahoor F, Shangraw RE, Miyoshi H, Wallfish H, Hemdon DN, Wolfe RR (1989) Role of insulin and glucose oxidation in mediating protein catabolism of burns and sepsis. Am J Physiol 275:E323-E331
34. Zang XJ, Kunkel KR, Jahoor F, Wolfe RR (1991) Role of basal insulin in the regulation of protein kinetics and energy metabolism in septic patients. JPEN J Parenter Enteral Nutr 15:394-349
35. Burke JF, Wolfe RR, Mullany CJ, Mathews DE, Bier DM (1980) Glucose requirements folowing burn injury. Ann Surg 190:274-285
36. Clarke PJ, Ball MJ, Kettlewell (1991) Liver function tests in patients receiving parenteral nutrition. JPEN J Parenter Enteral Nutr 15:54-59
37. Quigley EMM, Marsh MN, Shaffer JL, Markin RS (1993) Hepatobiliary complications of total parenteral nutrition. Gastroenterology 104:286-301
38. Buchmiller CE, Kleiman Wexler RL, Ephgrave KS, Booth B, Hensley II CE (1993) Liver dysfunction and energy source: results of a randomized clinical trial. JPEN J Parenter Enteral Nutr 17:301-306
39. Messing B, Bitoun A, Galian A, Mary JY, Goll A, Bernier JJ (1977) La stéatose hépatique au cours de la nutrition parentérale dépend-elle de l'apport calorique glucidique? Gastroenterol Clin Biol 1:1015-1025