Effects of clopidogrel and aspirin in combination versus aspirin alone on platelet activation and major receptor expression in patients after recent ischemic stroke: For the Plavix Use for Treatment of Stroke (PLUTO-Stroke) trial

Stroke

Volumn 36, Issue 10, 2005, Pages 2289-2292

  Serebruany, Victor L ^a,e   Malinin, Alex I ^a   Ziai, Wendy ^b   Pokov, Alex N ^a   Bhatt, Deepak L ^c   Alberts, Mark J ^d   Hanley, Dan F ^b  

^a HeartDrug Research Laboratories   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e Osler Medical Center   (United States)

Author keywords

Aspirin; Clinical trial; Clopidogrel; Platelets; Stroke

Indexed keywords

ACETYLSALICYLIC ACID; CD31 ANTIGEN; CLOPIDOGREL; COLLAGEN; FIBRINOGEN RECEPTOR; NANOPARTICLE; PADGEM PROTEIN; RECEPTOR; VITRONECTIN RECEPTOR;

ADULT; AGED; ANALYZER; ARTICLE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE; DRUG POTENCY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HOSPITALIZATION; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; TREATMENT OUTCOME;

AGED; ALGORITHMS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BIOLOGICAL MARKERS; BLOOD PLATELETS; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; DRUG THERAPY, COMBINATION; FEMALE; FLOW CYTOMETRY; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; TICLOPIDINE; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 26444462488     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000181081.09262.e1     Document Type: Article

References (13)

1. CAPRIE Steering Committee. A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events. Lancet. 1996;348:1329-1339.
2. Ruggeri ZM. New insights into the mechanisms of platelet adhesion and aggregation. Semin Hematol. 1994;31:229-239.
3. Mammen EF, Comp PC, Gosselin R, Greenberg C, Hoots WK, Kessler CM, et al. PFA-100 system: a new method for assessment of platelet dysfunction. Semin Thromb Hemost. 1998;24:195-202.
4. Smith JW, Steinhubl SR, Lincoff AM, Coleman JC, Lee TT, Hillman RS, Coller BS. Rapid platelet-function assay. An automated and quantitative cartridge-based method. Circulation. 1999;99:620-625.
5. Ault KA. Flow cytometric measurement of platelet function and reticulated platelets. Ann N Y Acad Sci. 1993;677:293-308.
6. Grau AJ, Reiners S, Lichy C, Buggle F. Ruf A. Platelet function under aspirin, clopidogrel, and both after ischemic stroke: a case-crossover study. Stroke. 2003;34:849-854.
7. Gan R, Teleg RA, Florento L, Bitanga ES. Effect of increasing doses of aspirin on platelet aggregation among stroke patients. Cerebrovasc Dis. 2002;14:252-255.
8. Pongracz E. Measurement of platelet aggregation during antiplatelet therapy in ischemic stroke. Clin Hemorheol Microcirc. 2004;30:237-242.
9. Mattiasson I, Lethagen S, Hillarp A. Increased sensitivity to ADP-aggregation in aspirin treated patients with recurrent ischemic stroke? Int Angiol. 2003;22:239-242.
10. Serebruany VL, Malinin AI, Jerome SD, Lowry DR, Morgan AW, Sane DC, Tanguay J-F, Steinhubl SR, O'Connor CM. Effects of clopidogrel and aspirin combination versus aspirin alone on platelet aggregation and major receptor expression in patients with heart failure: the Plavix Use for Treatment of Congestive Heart Failure (PLUTO-CHF) trial. Am Heart J. 2003;146:713-720.
11. Serebruany VL, Midei MG, Malinin AI, Oshrine BR, Lowry DR, Sane D, Tanguay JF, Steinhubl SR, Berger PB, O'Connor CM, Hennekens CH. Absence of Interaction Between Atorvastatin and Clopidogrel in Prospective Data: The Interaction of Atorvastatin and Clopidogrel (INTERACTION Study). Arch Intern Med. 2004;164:2051-2057.
12. Alberts MJ, Bergman DL, Molner E, Jovanovic BD, Ushiwata I, Teruya J. Antiplatelet effect of aspirin in patients with cerebrovascular disease. Stroke. 2004;35:175-178.
13. McCabe DJ, Harrison P, Mackic IJ, Sidhu PS, Purdy G, Lawrie AS, Watt H, Brown MM, Machin SJ. Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack. Br J Haematol. 2004;125:777-787.