Effect of mitoxantrone on DNA polymerase of Ehrlich ascites carcinoma cells

Acta Pharmacologica Sinica

Volumn 19, Issue 4, 1998, Pages 356-358

  Xian, Li Jian ^a   Li, Han Xi ^a   Liu, Zong Chao ^a   Pan, Qi Chao ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Aphidicolin; DNA polymerases; Doxorubicin; Ehrlich tumor carcinoma; Enzyme inhibitors; Mitoxantrone

Indexed keywords

APHIDICOLIN; DNA POLYMERASE; DOXORUBICIN; MITOXANTRONE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS INHIBITION; EHRLICH ASCITES TUMOR; ENZYME INHIBITION; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CARCINOMA, EHRLICH TUMOR; DNA POLYMERASE BETA; DNA POLYMERASE I; DNA-DIRECTED DNA POLYMERASE; DOXORUBICIN; INHIBITORY CONCENTRATION 50; MALE; MICE; MITOXANTRONE; TUMOR CELLS, CULTURED;

EID: 2642702578     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Kapuscinski J, Darzynkiewicz Z, Traganos F, Melamed MR. Interactions of a new antitumor agent, 1, 4-dihydroxy-5, 8-bis[[2-[(2-hydroxyethyl) amino]-ethyl] amino] 9, 10-anthracenedione, with nucleic acids. Biochem Pharmacol 1981; 30: 231-40.
2. Weissbach A, Baltimore D, Bollum F, Gallo R, Korn D. Nomenclature of eukaryotic DNA polymerases. Science 1975; 190: 401-2.
3. Bolden A, Noy GP, Weissbach A. DNA polymerase of mitochondria is a γ-polymerase. J Biol Chem 1977; 252: 3351-6.
4. Goulian M, Herrmann SM, Sackett JW, Grimm SL. Two forms of DNA polymerase δ from mouse cells: purification and properties. J Biol Chem 1990; 265: 16402-11.
5. Kesti T, Frantti H, Syväoja JE. Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase ε. J Biol Chem 1993; 268: 10238-45.
6. Pan QC, Xiu B, editors. Cancer pharmacology and chemotherapy. Guangzhou: Guangdong Higher Education Press; 1989. p 115-6.
7. Ono K. Discrimination of cellular and viral DNA polymerases in retrovirus-infected cells: principle and application. Bull Inst Pasteur 1987; 85: 3-35.
8. Chen HL, Li WJ, editors. Molecular enzymology. Beijing: People's Medical Publishing House; 1983. p 229-70.
9. Fox G, Popanda O, Edler L, Thielmann HW. Preferential inhibition of DNA polymerases α, δ, and ε from Novikoff hepatoma cells by inhibitors of cell proliferation. J Cancer Res Clin Oncol 1996; 122: 78-94.
10. Tanaka M, Yoshida S. Mechanism of the inhibition of calf thymus DNA polymerases α and β by daunomycin and adriamycin. J Biochem 1980; 87: 911-8.