An Efficient and Selective Method for the Preparation of Iodophenols

Journal of Organic Chemistry

Volumn 55, Issue 18, 1990, Pages 5287-5291

  Edgar, Kevin J ^a   Falling, Stephen N ^a  

^a EASTMAN KODAK COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 2642697712     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo00305a026     Document Type: Article

References (52)

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36. A referee has suggested the following mechanism for the iodination of phenols with NaI/NaOCl:
37. where XA could be: IC1,I2, ClOH, etc. While we find the mechanism intriguing and are grateful to the referee for suggesting it, we do not feel that it explains adequately the variation in para/ortho ratio with the bulk of the R group in ROH solvent. The position of attack (ortho or para) of iodine ion on ii should be relatively independent of the bulk of R.
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